Mortality among men occupationally exposed to phosgene in 1943–1945

Polednak, Anthony P.

doi:10.1016/0013-9351(80)90147-4

Cited by 24 publications

(3 citation statements)

References 9 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Individuals that survive phosgene inhalation generally have a good long-term prognosis [26][27][28][29]. However, survivors may have persistent exertional dyspnea, reduced pulmonary function, and decreased levels of physical fitness for months or even years after exposure [30].…”

Section: Discussionmentioning

confidence: 99%

Phosgene Exposure: A Case of Accidental Industrial Exposure

2013

View full text Add to dashboard Cite

Introduction Phosgene is a rare exposure with strong clinical implications. We report a phosgene exposure that resulted in the patient's death. Case Report A 58 year-old man arrived to the emergency department 1 hour after exposure to phosgene with complaints of a sore throat. Initial vital signs were blood pressure 175/118 mmHg, heart rate 98/min, respirations 12/min, and oxygen saturation of 93% on room air. Physical exam revealed few scattered rhonchi, without signs of distress. Initial arterial blood gases (ABG's) revealed pH 7.42, pCO2 43 mmHg, pO2 68 mmHg, HCO3 27 meq/L, and oxygen saturation of 93% on room air. Initial chest x-ray 2 hours after the exposure demonstrated clear lung fields. Approximately 2.5 hours after the exposure, he began complaining of dyspnea, restlessness and his oxygen saturation dropped below 90%.He received nebulized albuterol, 1 gram intravenous methylprednisolone, and 100 % oxygen via face mask. Minimal improvement was noted and he was intubated. The post intubation chest x-ray, 3.5 hours after the exposure, revealed diffuse alveolar infiltrates. Acetylcysteine, terbutaline, and IV steroids were administered without improvement. The patient died 30 hours after exposure. Discussion There are many misunderstandings concerning phosgene due to its rare presentation. Traditional treatment modalities are often unproven in human trials and were unsuccessful in this case. Conclusion This case highlights the significant toxicity that results from phosgene exposure and the challenges of the limited treatment modalities. There is concern for the use of this agent in chemical terrorism.

show abstract

Section: Discussionmentioning

confidence: 99%

Phosgene Exposure: A Case of Accidental Industrial Exposure

2013

View full text Add to dashboard Cite

show abstract

“…Polednak (1980) and Polednak and Hollis (1985) examined a cohort of chemical workers exposed to chronic low levels of phosgene as well as daily exposures more than 1 ppm. Polednak (1980) and Polednak and Hollis (1985) examined a cohort of chemical workers exposed to chronic low levels of phosgene as well as daily exposures more than 1 ppm.…”

Section: Cancermentioning

confidence: 99%

Phosgene

Bast¹,

Glass-Mattie²

2015

Handbook of Toxicology of Chemical Warfare Agents

View full text Add to dashboard Cite

“…Auch die allgemeine bzw. pulmonale Standardmortalitätsrate von 699 Chemiearbeitern, die langfristig Phosgenkonzentrationen bis über 1 ml/m 3 ausgesetzt waren, zeigte keinen Unterschied gegenüber derjenigen von 9352 nichtexponierten Kontrollpersonen [8].…”

Section: Erfahrungen Beim Menschenunclassified

Phosgen (Carbonylchlorid) [MAK Value Documentation in German language, 1984]

2012

The MAK‐Collection for Occupational Health and Safety

View full text Add to dashboard Cite

Veröffentlicht in der Reihe Gesundheitsschädliche Arbeitsstoffe , 10. Lieferung, Ausgabe 1984 Der Artikel enthält folgende Kapitel: Allgemeiner Wirkungscharakter Erfahrungen beim Menschen Mutagenität Begründung des MAK‐Wertes

show abstract

Mortality among men occupationally exposed to phosgene in 1943–1945

Cited by 24 publications

References 9 publications

Phosgene Exposure: A Case of Accidental Industrial Exposure

Phosgene Exposure: A Case of Accidental Industrial Exposure

Phosgene

Phosgen (Carbonylchlorid) [MAK Value Documentation in German language, 1984]

Contact Info

Product

Resources

About