Mortality among Participants in the Multicenter AIDS Cohort Study and the Women's Interagency HIV Study

Hessol, Nancy A.; Kalinowski, Ann; Benning, Lorie; Mullen, Joanne; Young, Mary; Palella, Frank J.; Anastos, Kathryn; Detels, Roger; Cohen, Mardge H.

doi:10.1086/510488

Cited by 91 publications

(58 citation statements)

References 23 publications

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“…In addition, the Multicenter AIDS Cohort Study and the Women's Interagency HIV Study have shown that higher alcohol use is associated with significantly increased risk for mortality in HIV-positive individuals [56]. Chronic alcohol administration induces increased viral load and accelerated significant and early nutritional, metabolic, and immunologic alterations in HIV-positive animals [57], but the identification of direct toxic effects and the translation of such effects to humans require further investigation.…”

Section: Risky Behaviors: the Hiv Examplementioning

confidence: 99%

Medical comorbidity and alcohol dependence

Mannelli

Pae²

2007

Curr Psychiatry Rep

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Alcohol dependence (AD) and, more generally, alcohol use disorders (AUDs) predispose individuals to adverse consequences that extend beyond the expected damage from alcohol-direct toxicity. Research has shown that the relationship of alcohol use to health outcomes is complex, as is the etiology of AD, and that the individual and social costs of alcohol-related problems are increasing. We review advances in alcohol science that explore the role of alcohol consumption and patterns of drinking in a range of medically comorbid conditions. Although new knowledge can assist in the development of appropriate medical management strategies, AUDs account for an important percentage of the global burden of disease and require approaches that are not uniquely focused on the identification and treatment of AD.

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Section: Risky Behaviors: the Hiv Examplementioning

confidence: 99%

Medical comorbidity and alcohol dependence

Mannelli

Pae²

2007

Curr Psychiatry Rep

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“…Benzer olarak alkol kullanan kişilerde viral yükün saptanamaz hale gelmesi de dört kat yavaş olmaktadır (p=0,04). Literatürde alkol kullanımının virolojik başarısızlık ve CD4 T lenfositlerin sayısında düşüklükle ilişkisini gösteren birçok çalışma bulunmaktadır [35][36][37][38] .…”

Section: Alkolunclassified

Recreational Drugs and Antiretrovirals: Is It Worth the World or Trivial?

Kara¹,

İnkaya²,

Demirkan³

et al. 2018

mjima

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According to the World Health Organization, 1 out of 200 people in the world was living with Human immunodeficiency virus (HIV)/Acquired immune deficiency syndrome (AIDS) in 2015 and four new HIV infections occurred each minute. A relationship between HIV infection and recreational drug use was evident from the very beginning of the HIV epidemic. Recreational drug use is more common in patients living with HIV/AIDS compared to others. Needle-sharing activities, psychological and cognitive consequences of the abused substances facilitate new infections. It is assumed that 1.650.000 individuals were infected with HIV out of 12.190.000 intravenous drug users in 158 countries in 2013. Cytochrome isoenzymes (i.e. CYP3A4, CYP2D6) are responsible from metabolism of non-nucleoside reverse transcriptase inhibitors, protease inhibitors, integrase inhibitors and chemokine receptor 5 inhibitors as well as recreational drugs. Recreational and antiretroviral drugs (ARV) may share the same metabolic pathways resulting in drug interactions. Drug interactions may occur because of pharmacodynamic and pharmacokinetic properties of the drugs. Induction of CYP3A4 (due to cocaine, tobacco, chronic alcohol use, etc.) may lead to decreased antiretroviral treatment (ART) effectiveness and increased risk of metabolites-related toxicity, however, inhibition of CYP3A4 (due to marijuana, acute alcohol use, etc.) may lead to increased side effects and drug toxicity. The feeling of moving away from reality and reduction of social pressure associated with recreational drugs mean all the world to the user. However, drug interaction risk makes it challenging for the physicians, when it is time for the selection of ARV. Therefore, physicians' awareness on Abstract Özİnsan immün yetmezlik virüsü ["Human immunodeficiency virus" (HIV)]/Edinsel immün yetmezlik sendromu ["Acquired immune deficiency syndrome" (AIDS)] ile yaşayan insan sayısı, 2015 yılı Dünya Sağlık Örgütü verilerine göre, dünya üzerinde yaşayan tüm insanların yaklaşık 1/200'ini oluşturmaktadır ve her dakika yaklaşık dört kişi HIV ile enfekte olmaktadır. İnsan immün yetmezlik virüsü/Edinsel immün yetmezlik sendromu salgını ilk ortaya çıktığı zamandan itibaren keyif verici madde kullanıcıları ile salgın arasında bir ilişki olduğu fark edilmiştir. Keyif verici maddelerin kullanımı HIV/AIDS ile yaşayan bireylerde genel nüfusa oranla daha fazla görülmektedir. Bu ilişkide enjektörlerin paylaşılması, kullanılan maddelerin neden olduğu psikolojik ve bilişsel durumun etkisi gibi faktörler rol oynamakta ve bulaşı kolaylaştırmaktadır. Tahminlere göre 2013 yılında 158 ülkede 12 milyon 190 bin damar içi madde kullanıcısı bulunmaktadır ve bu kişilerin yaklaşık 1.650.000'i HIV ile enfektedir. Sitokrom izoenzimleri (örneğin; CYP3A4, CYP2D6) antiretroviral tedavide (ART) kullanılan ilaçlardan non-nükleozit revers transkriptaz inhibitörleri, proteaz inhibitörleri, integraz inhibitörleri ve kemokin reseptör tip 5 inhibitörlerinin ve aynı zamanda keyif verici maddelerin metabolizasyonundan...

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“…A Swiss study was excluded because it evaluated social co-factors of HIVnon-progression but not mortality [59]. A cohort study on mortality among HIV-infected participants in the Women's Interagency HIV Study and the Multicenter AIDS Cohort Study were excluded because it focused only on accident-and injury-related deaths [60].…”

Section: Literature Searchmentioning

confidence: 99%