Mortality and Cancer Incidence in Aluminum Smelter Workers

Gibbs, Graham W.; Busque, Marc-Antoine; Duguay, Patrice

doi:10.1097/jom.0000000000000175

Cited by 22 publications

(11 citation statements)

References 16 publications

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“…GC is the most common cancer worldwide and the third leading cause of global cancer-related death (1,2). As a Group Ⅰ carcinogen categorized by the IARC, BaP has been confirmed to induce several types of cancers and play important roles in gastric carcinogenesis (8,15,16,30). In this study, we aimed to explore the effects of BaP on GC cell proliferation and metastasis and its regulatory mechanism.…”

Section: Discussionmentioning

confidence: 99%

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Benzo[a]pyrene promotes gastric cancer cell proliferation and metastasis likely through the Aryl hydrocarbon receptor and ERK-dependent induction of MMP9 and c-myc

Wei

Zhao

et al. 2016

International Journal of Oncology

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Gastric cancer (GC) is the fifth most common cancer worldwide and the third leading cause of global cancer-related death. Benzo[a]pyrene (BaP), a Group Ⅰ carcinogen categorized by the IARC, is a cumulative foodborne carcinogen and ubiquitous environmental pollutant with potent carcinogenic properties. However, the function and mechanism of BaP exposure on GC progression remains unclear. We investigated the role of BaP in human GC progression to identify potential mechanism underlining its carcinogenic activity. After exposure to various concentrations of BaP, human GC cells SGC-7901 and MNK-45 showed an increased capability of proliferation, migration and invasion. Further study indicated that BaP promotes the expression of matrix metalloproteinase-9 (MMP9) and c-myc at mRNA and protein level, and activates Aryl hydrocarbon receptor (AhR) and ERK pathway. Moreover, BaP-induced overexpression of MMP9 and c-myc were attenuated by the ERK inhibitor U0126 and AhR inhibitor resveratrol, respectively. These data suggest that BaP promotes proliferation and metastasis of GC cells through upregulation of MMP9 and c-myc expression, and this was likely mediated via the AhR and ERK signaling pathway.

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Section: Discussionmentioning

confidence: 99%

“…Epidemiologic study found that long-term exposure to BaP significantly increased the mortality in GC patients (30), suggesting that BaP plays a critical role in GC advancement. However, little is known about BaP in GC development and progression.…”

Section: Benzo[a]pyrene Promotes Gastric Cancer Cell Proliferation Anmentioning

confidence: 99%

Benzo[a]pyrene promotes gastric cancer cell proliferation and metastasis likely through the Aryl hydrocarbon receptor and ERK-dependent induction of MMP9 and c-myc

Wei

Zhao

et al. 2016

International Journal of Oncology

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“…Only the studies by Gibbs et al 26 and Gustavsson et al 27 measured exposure to PAH as BaP-years determined through the monitoring of workplace air samples. However, only Gibbs et al used these measurements for reporting the risks of larynx cancer.…”

Section: Resultsmentioning

confidence: 99%

“…Gibbs et al 26 examined the larynx cancer incidence in several cohorts of workers employed at one of five aluminium production plants in Quebec, Canada. Cumulative exposure dose and SIR were reported for the combined cohort of 16 301 men.…”

Section: Discussionmentioning

confidence: 99%

Occupational polycyclic aromatic hydrocarbon exposure and risk of larynx cancer: a systematic review and meta-analysis

Wagner

Bolm‐Audorff²,

Hegewald

et al. 2014

Occup Environ Med

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Polycyclic aromatic hydrocarbons (PAH) are genotoxic substances formed during combustion. Occupational PAH exposure has been shown to increase the risk of lung cancer and may be associated with other respiratory cancers. We conducted a systematic review and meta-analysis to clarify the relationship between occupational PAH exposures and larynx malignancies. We searched EMBASE and MEDLINE (until July 2014) using a series of search strings developed to seek case-control studies or longitudinal studies of workers (Population) exposed to PAHs (Exposure) and their risk for larynx cancer incidence and/or mortality (Outcome). Two independent reviewers screened the titles and abstracts for eligible articles and a third reviewer negotiated consensus. Further assessments of eligibility and sources of bias were conducted in a similar manner. The study results were pooled with random effects meta-analysis. The search resulted in 3377 records. The data of 92 full-text articles representing 63 studies were included and extracted. The majority of studies (n=47) was judged likely to be biased; only 16 studies were judged as methodologically adequate. The pooled effect size was 1.45 (95% CI 1.30 to 1.62; I(2)=30.7%; [Formula: see text]=0.03) for larynx cancer incidence and 1.34 (95% CI 1.18 to 1.53; I(2)=23.8%; [Formula: see text]=0.03) for larynx cancer mortality. While few studies allowed an investigation of dose-response, these indicate a positive dose-response effect. Although most studies may underestimate the true effect due to inexact approximations of PAH exposure, the meta-analysis suggests a robust positive association between PAH and larynx cancer.

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“…Nowadays, authors conclude that exposure levels to know health hazards associated with the emissions from primary aluminum production should be studied to establish a clear relationship between inhaled aluminum exposure and cancer [48]. The carcinogenic mechanisms of inhaled aluminum exposure are associated to different compounds an not with the metal per se, as it is described in different studies [49].…”

Section: Metals and Its Relationship With Cancermentioning

confidence: 99%