Mortality and Deep Vein Thrombosis in the Gamma Variant of Covid 19 and Lung Injury

Cunha, Carolina Hungaro; Sato, Debora Yuri; Godoy, José María Pereira de; Russeff, Gleison Juliano da Silva; Silva, Desirée Franccini Del Frari; Godoy, Henrique Jose Pereira de; Silva, Mariana Orate Menezes da; Santos, Henrique Amorim; Godoy, Maria de Fátima Guerreiro

doi:10.2147/vhrm.s367930

Cited by 3 publications

(1 citation statement)

References 8 publications

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“…The frequency of thrombotic events in the Delta strain was 35% versus 25% in previous strains [119]. The same was shown for the lesser-known Gamma variant [120]. The incidence of acute limb ischemia doubled with the onset of Delta [121].…”

Section: Evolution Of Coronavirus and Its Hematological Interactionssupporting

confidence: 59%

The Ways of the Virus: Interactions of Platelets and Red Blood Cells with SARS-CoV-2, and Their Potential Pathophysiological Significance in COVID-19

Panteleev,

Sveshnikova,

Shakhidzhanov

et al. 2023

IJMS

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The hematological effects of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) are important in COVID-19 pathophysiology. However, the interactions of SARS-CoV-2 with platelets and red blood cells are still poorly understood. There are conflicting data regarding the mechanisms and significance of these interactions. The aim of this review is to put together available data and discuss hypotheses, the known and suspected effects of the virus on these blood cells, their pathophysiological and diagnostic significance, and the potential role of platelets and red blood cells in the virus’s transport, propagation, and clearance by the immune system. We pay particular attention to the mutual activation of platelets, the immune system, the endothelium, and blood coagulation and how this changes with the evolution of SARS-CoV-2. There is now convincing evidence that platelets, along with platelet and erythroid precursors (but not mature erythrocytes), are frequently infected by SARS-CoV-2 and functionally changed. The mechanisms of infection of these cells and their role are not yet entirely clear. Still, the changes in platelets and red blood cells in COVID-19 are significantly associated with disease severity and are likely to have prognostic and pathophysiological significance in the development of thrombotic and pulmonary complications.

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Section: Evolution Of Coronavirus and Its Hematological Interactionssupporting

confidence: 59%

The Ways of the Virus: Interactions of Platelets and Red Blood Cells with SARS-CoV-2, and Their Potential Pathophysiological Significance in COVID-19

Panteleev,

Sveshnikova,

Shakhidzhanov

et al. 2023

IJMS

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show abstract

Changes in the pathophysiology of viral variants of COVID-19 with a significant reduction in thrombotic events

Godoy,

Russeff

2024

Rev. Assoc. Med. Bras.

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Prevalence of COVID-19 Among 8000 Patients at a Hospitalized and Mortality in Old Age

Godoy

Salomão

et al. 2024

CAS

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Background: COVID-19 created a general challenge to healthcare systems throughout the world and was an important cause of mortality. Aim: Aim: The aim of the present study was to report the general evolution of patients with COVID-19 at a teaching hospital and analyze differences by age group and sex considering mortality rates in the years 2020 and 2021 among patients older than 60 years of age. Method: A cross-sectional study was conducted with patients hospitalized with a diagnosis of COVID-19 confirmed by RT-PCR at the São Jose do Rio Preto university hospital between March 2020 and March 2022. The patients were male and female patients, of varying ages belonging to the region of Sao Jose do Rio Preto, were accommodated in the wards or intensive care units (ICUs). Overall mortality was analyzed for the hospital as well as in the ICUs and wards. This analysis was performed separately in two years considering age group, sex, and main comorbidities in patients older than 60 years of age. Results: A total of 8032 patients with COVID-19 were hospitalized between March 2020 and March 2022: 2866 patients with 658 deaths (22.92%) in 2020; 4324 patients with 1168 deaths (27.01%) in 2021; and 842 patients with 205 deaths (24.35 %) in 2022 up to the month of March. More than half (53.60%) of the patients were hospitalized in the ICUs and 46.39% were hospitalized in the wards. Differences in the mortality rate were found for the different age groups in the comparison of the years, with more deaths occurring among individuals up to 90 years of age in the second year (p <0.05). Men were affected more and had a higher mortality rate (p <0.0001). The main comorbidities were cardiovascular disease (70.93%), diabetes (37.76%), and obesity (23.68%). Conclusions: The mortality rate of older people hospitalized with COVID-19 was higher than the average, it was higher in 2021 compared to 2020 and increased with age. Cardiovascular disease, diabetes, and obesity were the main comorbidities.

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Mortality and Deep Vein Thrombosis in the Gamma Variant of Covid 19 and Lung Injury

Cited by 3 publications

References 8 publications

The Ways of the Virus: Interactions of Platelets and Red Blood Cells with SARS-CoV-2, and Their Potential Pathophysiological Significance in COVID-19

The Ways of the Virus: Interactions of Platelets and Red Blood Cells with SARS-CoV-2, and Their Potential Pathophysiological Significance in COVID-19

Changes in the pathophysiology of viral variants of COVID-19 with a significant reduction in thrombotic events

Prevalence of COVID-19 Among 8000 Patients at a Hospitalized and Mortality in Old Age

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