Mortality and prognosis related to the amyloidosis of Still's disease.

Failure of cytotoxic drugs to suppress immune responses of patients with rheumatoid arthritis.

“…It could be argued that the patients in the present study were suffering from disease which was too advanced for successful treatment. This is particularly true for the patients with amyloidosis, whose poor prognosis is well recognized (Smith, Ansell, and Bywaters, 1968). Thus the clinical observations in this study give no useful answer to the question lucidly posed by Swanson and Schwartz (1967) whether immunosuppression is a necessary, irrelevant, or undesirable accompaniment of treatment with cytotoxic drugs.…”

Still's disease in the adult.

“…The picture is not compatible with that described here, although, if any of our patients had developed amyloidosis (as happened in 6 per cent. of our juvenile cases- Smith, Ansell, and Bywaters 1968), the similarity would be more marked. In view of the resemblance to familial Mediterranean fever, which includes serositis, recurrent arthritis, fever, and rash as well as amyloidosis, it should be stated that all our listed cases were of English stock except Case 13 (Italian).…”

“…(Bywaters, 1968). We have seen children with ankylosing spondylitis, with Crohn's 40 20 0 disease and arthritis, with ulcerative colitis and arthritis, and with psoriatic arthritis, and we realize that a number of children (as also adults) may have, for instance, psoriatic arthritis for a considerable time before they develop overt psoriasis.…”

Still’s Disease Mortality Trends in France, 1979–2016: A Multiple-Cause-of-Death Study

“…While considered as uncommon, amyloidosis has long been reported as a possible complication driving mortality in SD [ 38 , 39 ]. In this context, it is related to the deposition in tissues of serum amyloid A protein secondary to persistent or recurrent inflammation.…”