Mortality and years of life lost of colorectal cancer in China, 2005–2020: findings from the national mortality surveillance system

Abstract

Background: Colorectal cancer (CRC) is the fourth cause of cancer death in China. We aimed to provide national and subnational estimates and changes of CRC premature mortality burden during 2005–2020. Methods: Data from multi-source on the basis of the national surveillance mortality system were used to estimate mortality and years of life lost (YLL) of CRC in the Chinese population during 2005–2020. Estimates were generated and compared for 31 provincial-level administrative divisions in China. Results: Estimated CRC deaths increased from 111.41 thousand in 2005 to 178.02 thousand in 2020; age-standardized mortality rate decreased from 10.01 per 100,000 in 2005 to 9.68 per 100,000 in 2020. Substantial reduction in CRC premature mortality burden, as measured by age-standardized YLL rate, was observed with a reduction of 10.20% nationwide. Marked differences were observed in the geographical patterns of provincial units, and they appeared to be obvious in areas with higher economic development. Population aging was the dominant driver which contributed to the increase in CRC deaths, followed by population growth and age-specific mortality change. Conclusions: Substantial discrepancies were observed in the premature mortality burden of CRC across China. Targeted considerations were needed to promote a healthy lifestyle, expand cost-effective CRC early screening and diagnosis, and improve medical treatment to reduce CRC mortality among high-risk populations and regions with inadequate healthcare resources.

Disease Burden of Total and Early-Onset Colorectal Cancer in China from 1990 to 2019 and Predictions of Cancer Incidence and Mortality

“… 1 The burden of CRC is also crucial in China, ranking as the fourth leading cause of cancer-related deaths. 3 The interest in early-onset CRC (EOCRC) has been increasing, which is defined as CRC that occurs under the age of 50 years. A previous study conducted in nine high-income countries found that the incidence of EOCRC was increasing.…”

Safety and efficacy comparison of polyethylene glycol, hemp seed oil, and 5% sugar brine for bowel preparation in older patients: study protocol for a randomized controlled trial

“…According to a report of the cancer survey, colorectal cancer ranks in the top three in new cases and deaths in both men and women, making it one of the most life-threatening cancers among Chinese patients [ 1 , 2 ]. The progression of colorectal adenomas to cancer may take up to 10 years, and the incidence increases with age [ 3 – 6 ]. Moreover, the risk of mortality from colorectal cancer has been reported to decrease by 53% in patients who underwent endoscopic adenoma resection [ 7 – 10 ].…”

Low serum level of 25‐OH vitamin D relates to Th17 and treg changes in colorectal cancer patients

“…In China, estimated colorectal cancer (CRC) deaths increased from 111.41 thousand in 2005 to 178.02 thousand in 2020; age‐standardized mortality rate decreased from 10.01 per 100,000 in 2005 to 9.68 per 100,000 in 2020. 1 Vitamin D level is inversely associated with CRC development, influences prognosis, and survival rate. 2 In CRC patients undergoing surgery, vitamin D influences the risk of infectious complications.…”