2021
DOI: 10.1016/j.lanepe.2021.100243
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Mortality comparison between the first and second/third waves among 3,795 critical COVID-19 patients with pneumonia admitted to the ICU: A multicentre retrospective cohort study

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Cited by 128 publications
(136 citation statements)
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“…Previous studies however, have shown no difference between mortality in first and second wave. 13 In this study high inflammatory markers and high CT severity scoring is found to be associated with higher maternal mortality and morbidity. Treatment with Remedesvir did not show any significant difference in maternal outcome.…”
Section: Resultsmentioning
confidence: 57%
“…Previous studies however, have shown no difference between mortality in first and second wave. 13 In this study high inflammatory markers and high CT severity scoring is found to be associated with higher maternal mortality and morbidity. Treatment with Remedesvir did not show any significant difference in maternal outcome.…”
Section: Resultsmentioning
confidence: 57%
“…However, patients from w1 exhibited more brosis on chest CT compared with patients from w2, a result that can be explained by a lower use of GC in w1. W1 patients also reported worse QoL in vitality and mental health items versus those in w3, a result that is probably related to supplemental factors that affected emotional well-being in w1, such as reduced access to family members during ICU stay, isolation, and fear of spreading the virus to others [12].…”
Section: Discussionmentioning
confidence: 99%
“…Changes in ICU mortality are multifactorial, not exclusively related to changes in care but also to the direct effect of variants on severe disease and their indirect effect of strain to the healthcare system [ 34 , 35 ]. Improving practices in caring for COVID-19 patients in the ICU may have led to more favorable outcomes, though these associations are neither straightforward nor guaranteed and some studies did not show a dramatic improvement in mortality, regardless of changing practices in ICU during the pandemic [ 36 ]. Overall, it is highly unlikely that improving ICU care would alter the course of the pandemic in the same degree as an imperfect vaccine can avert severe cases, hospitalizations, and deaths and have a bulk effect on mortality [ 26–30 , 37 ].…”
Section: Discussionmentioning
confidence: 99%