Mortality from all-cause and cause-specific in the elderly: Joint implications of anemia and frailty

Zhang, HuanRui; Wei, Xuejiao; Chen, XiTao; Sun, XiaoDi

doi:10.1016/j.archger.2023.105213

Cited by 6 publications

(1 citation statement)

References 34 publications

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“…Up to 70% of HF patients have iron deficiency with or without anemia, playing a negative role in determining negative outcomes. 51 52) A recent analysis of 6,406 participants aged 60 years or older followed for 13-years follow-up form NHANES 2007–2014 study showed that elderly HF patients with low levels of hemoglobin and frailty have the greatest risk for all-cause, cardiovascular, cancer, and non-cancer/non-cardiovascular mortality, compared to those without frailty. This preliminary data suggests a potential role of iron supplementation specifically targeted for the management of frailty in HF patients.…”

Section: Management Of Frailty In Hfmentioning

confidence: 99%

The Dual Burden of Frailty and Heart Failure

Vitale,

Spoletini,

Rosano

2024

Int J Heart Fail

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Frailty is highly prevalent among patients with heart failure (HF) and independently predicts adverse outcomes. However, optimal frailty definitions, assessments, and management in HF remain unclear. Frailty is common in HF, affecting up to 80% of patients depending on population characteristics. Even pre-frailty doubles mortality risk versus robust patients. Frailty worsens HF prognosis through systemic inflammation, neurohormonal changes, sarcopenia, and micronutrient deficiency. Simple screening tools like gait speed and grip strength predict outcomes but lack HF-specificity. Comprehensive geriatric assessment is ideal but not always feasible. Exercise, nutrition, poly-pharmacy management, and multidisciplinary care models can help stablize frailty components and improve patient-centred outcomes. Frailty frequently coexists with and exacerbates HF. Routine frailty screening should guide supportive interventions to optimize physical, cognitive, and psychosocial health. Further research on HF-specific frailty assessment tools and interventions is warranted to reduce this dual burden.

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Section: Management Of Frailty In Hfmentioning

confidence: 99%