Mortality From Bacterial Meningitis in Children in Kosovo

Namani, Sadie; Milenkovic, Zvonko; Kuchar, Ernest; Koci, Remzie; Mehmeti, Murat

doi:10.1177/0883073811413280

Cited by 20 publications

(19 citation statements)

References 43 publications

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“…Surprisingly the analysis did not highlight any association between the delay before admission and death. This is not concordant with previous results described in the literature [6][7][8]. This absence of association in this analysis could be explained by the fact that these delays are reported in days in our current system of surveillance and not hours as is usually done in the literature.…”

Section: Discussioncontrasting

confidence: 80%

Vital Prognostic Factors of Bacterial Meningitis in Morocco: A 12-year Study

Watanabe¹,

Uchida²,

Satoko³

et al. 2017

J Clin Exp Pathol

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Objectives: Bacterial meningitis remains a life-threatening public health risk in Meknes with the lethality ratio surprisingly increasing from 12. 7%, 18.8% to 23.2% in 2007-2009, 2010-2012 and 2013-2015 respectively. However, to our knowledge, there are no published studies analyzing predictor factors of mortality explaining this increase in meningitis-induced mortality in Meknes. Hence, the objective was to identify the predictor factors of mortality of bacterial meningitis in Meknes in order to enhance the case management system. Study Design: Case series study. Methods:We conducted a case series study of surveillance data from Meknes collected in 2004-2015 and performed analysis by using Epi-Info 7 and Excel 2007. The outcome variable of interest was death. Univariate analysis and logistic regression were conducted to identify vital prognostic factors. The statistical significance of the results obtained was assessed using confidence interval of the estimated odds ratios and the Pearson chi-squared test. Results:The total number of reported meningitis cases was 271. The median age was 6 years. The sex ratio male/female was 1.4. The average case fatality rates per 100.000 populations were 0. 35, 0.43 and 0.78 between 2007-2009, 2010-2012 and 2013-2015 respectively. The vital prognostic factors are conscious alterations (AOR: 5.36; p=0.003), probable meningococcal meningitis (AOR: 6.42, p=0.004) and coma (AOR: 21.76, p<0.0001). Conclusions:All vital prognostic factors we identified are late factors. Unfortunately, the delay before admission to the hospital is reported in days in our current surveillance program and was not found to be a vital prognostic factor. This is probably introducing a limit in the analysis. Hence, to better characterize the underlying factors leading to death, we propose to adjust our management of cases by ensuring delays before admission are shortened and reported within hours and not days. We propose to tackle meningitis by: (i) shortening admission delays, (ii) improving early case management; (iii) strengthening prevention efforts.

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Section: Discussioncontrasting

confidence: 80%

Vital Prognostic Factors of Bacterial Meningitis in Morocco: A 12-year Study

Watanabe¹,

Uchida²,

Satoko³

et al. 2017

J Clin Exp Pathol

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“…The data correspond well with the data from the literature. 3,4 Our study, like many other studies, shows that young children (those younger than age 5 years) are at the greatest risk of a severe outcome and death. 14 It is very alarming to note that most of the patients suffered from potentially vaccine-preventable infections.…”

Section: Discussionsupporting

confidence: 76%

Etiology and Complications of Central Nervous System Infections in Children Treated in a Pediatric Intensive Care Unit in Poland

et al. 2013

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Central nervous system infections are significant causes of mortality and long-term neurologic complications in children. Survivors often require an extended period of rehabilitation. The authors carried out a retrospective analysis of 1158 children (aged 1 month to 16 years; 31 boys) treated in one pediatric intensive care unit in Warsaw between 2002 and 2010. Forty-three of 1158 (3.7%) children presented with neuroinfections. Nearly two-thirds of the children were younger than age 5 years. The majority of cases (62.8%) were vaccine-preventable bacterial infections. The most frequent complications were brain edema (30.2%), brain hemorrhage (27.9%), and secondary nosocomial pneumonia (25.6%). One-fifth of children developed late, long-term neurologic complications. The mortality rate was 20.9%. The study showed that central nervous system infections are significant causes of hospitalization in the pediatric intensive care unit and often result in death or long-term complications. These infections mainly affect children younger than age 5 years. The majority could be prevented with immunizations.

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“…Seizures have been reported at hospital admission in 10-56% of children. Altered mental status was reported in 13-56% of the cases of childhood bacterial meningitis [22,34,38]. Some signs or symptoms are associated with specific pathogens of childhood meningitis.…”

Section: Diagnosis Of Community-acquired Bacterial Meningitismentioning

confidence: 99%