Mortality From Cancer and Other Causes in an Italian Cohort of Male Rubber Tire Workers

Pira, Enrico; Pelucchi, Claudio; Romano, Canzio; Manzari, Marco; Negri, Eva; Vecchia, Carlo La

doi:10.1097/jom.0b013e318244503c

Cited by 5 publications

(13 citation statements)

References 21 publications

(20 reference statements)

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Occupational exposure to aromatic amines has long been recognized a risk factor for bladder cancer (Negri et al, 1989;Kogevinas et al, 2003;Bosetti et al, 2005;Pira et al, 2010;Pira et al, 2012), accounting for up to 15% of cases in men from selected high-risk populations D'Avanzo et al, 1995). However, a selected number of occupations a priori deemed as being of high risk for bladder cancer showed only a moderate, nonsignificant excess risk, indicating that occupational exposures are not a major factor for bladder cancer in this, mainly rural, population.…”

Section: Discussionmentioning

confidence: 95%

Smoking, occupation, history of selected diseases and bladder cancer risk in Manisa, Turkey

Erdurak

Dündar

Özyurt

et al. 2014

European Journal of Cancer Prevention

Self Cite

View full text Add to dashboard Cite

The aim of the study was to identify and quantify the reasons for the high bladder cancer rates in Turkey. We conducted a case-control study in Manisa, Turkey, in 2011. The study included 173 patients with incident, histologically confirmed bladder cancer and 282 controls who were frequency matched by age, sex and geographic area, admitted to the main hospital of Manisa for a wide range of acute diseases. Adjusted odds ratios (ORs) and the corresponding 95% confidence intervals (CIs) were derived from multiple logistic regression models. Compared with never smokers, the OR was 2.9 (95% CI 1.5-5.4) for moderate (<20 cigarettes/day) and 4.0 (95% CI 1.7-9.6) for heavy smokers. The association was stronger for unfiltered black tobacco (OR=5.4) and for longer duration of smoking (≥40 years, OR=5.3). There was a strong inverse correlation with social class indicators, with ORs of 0.2 (95% CI 0.1-0.4) for more-educated compared with less-educated individuals. There was no significant association with a group of five occupations a priori defined as being of high risk (OR=1.3), nor with farming (OR=1.2). Bladder cancer risk was directly related to the history of urinary tract infections (OR=1.9, 95% CI 1.2-3.1) but not to diabetes (OR=0.7) or kidney (OR=0.7) and prostate (OR=1.3) diseases. Tobacco is the major risk factor for bladder cancer in Manisa, being responsible for 56% of cases; urinary tract infections account for 19% of cases, whereas the role of occupational exposure is limited in this, predominantly rural, population.

show abstract

Section: Discussionmentioning

confidence: 95%

Smoking, occupation, history of selected diseases and bladder cancer risk in Manisa, Turkey

Erdurak

Dündar

Özyurt

et al. 2014

European Journal of Cancer Prevention

Self Cite

View full text Add to dashboard Cite

show abstract

“…Table summarizes 26 articles describing 26 mortality studies of 14 occupational cohorts involving 270,408 workers (range: 327‐40 867) . These mortality studies included workers from facilities in the United States ( n = 13), Germany (4), United Kingdom (4), Italy (2), Sweden (2), and one study included facilities from five European countries (Germany, Italy, Poland, Sweden, and United Kingdom).…”

Section: Resultsmentioning

confidence: 99%

Non‐malignant respiratory disease among workers in the rubber manufacturing industry: A systematic review and meta‐analysis

Thapa

Tomasi

Cox‐Ganser

et al. 2019

American J Industrial Med

View full text Add to dashboard Cite

Background: Non-malignant respiratory disease (NMRD) cases have occurred among rubber manufacturing workers. We examined exposure to rubber manufacturing emissions as a risk factor for NMRD.Methods: From a systematic literature review, we identified case reports and assessed cross-sectional and mortality studies for strength of evidence of positive association (strong, intermediate, non-significant positive association, none) between exposure to rubber manufacturing emissions and NMRD-related morbidity and mortality, and conducted two meta-analyses. Results:We analyzed 62 articles. We identified 11 cases of NMRD. Nine (30%) of 30 cross-sectional studies and one (4%) of 26 mortality studies had strong evidence. The summary odds ratio and SMR for the cross-sectional and mortality meta-analyses were 3.83 (95% confidence interval [CI], 2.28-6.51) and 0.90 (95%CI, 0.82-0.99), respectively. Conclusion:Available evidence supports rubber manufacturing emissions as a potential risk factor for NMRD-related morbidity. Further investigations with longer follow-up periods and inclusion of short-tenured workers could further define risks for NMRD and identify prevention strategies. K E Y W O R D Schronic bronchitis, chronic obstructive pulmonary diseases, emphysema, eosinophilia, nonmalignant respiratory disease, occupational asthma, occupational lung disease, rubber

show abstract

“…Several other recent cohort studies of rubber workers performed in Germany, the United Kingdom, and Italy reported similar findings. 93–95 It is unknown to what extent these recent studies were affected by the Healthy Worker Effect. For additional information on the lung cancer risk associated with rubber manufacturing, see http://monographs.iarc.fr/ENG/Monographs/vol100F/mono100F-36.pdf.…”

Section: Iarc Group 1 Lung Carcinogens: Occupations and Manufacturingmentioning

confidence: 99%

Occupational and Environmental Causes of Lung Cancer

Field

Withers

2012

Clinics in Chest Medicine

145

View full text Add to dashboard Cite

Mortality From Cancer and Other Causes in an Italian Cohort of Male Rubber Tire Workers

Abstract: This study shows no excess cancer risk among male rubber tire workers employed after 1954.

Cited by 5 publications

References 21 publications

Smoking, occupation, history of selected diseases and bladder cancer risk in Manisa, Turkey

Smoking, occupation, history of selected diseases and bladder cancer risk in Manisa, Turkey

Non‐malignant respiratory disease among workers in the rubber manufacturing industry: A systematic review and meta‐analysis

Occupational and Environmental Causes of Lung Cancer

Contact Info

Product

Resources

About