Mortality from liver cirrhosis in Espírito Santo State, Brazil

Abstract

To study mortality from liver cirrhosis in Espírito Santo State, Brazil, we reviewed death certificates (DC) from 2000-2010 and medical records of deceased patients with investigation of alcoholism and hepatitis B or C. From a total of 218,410 DC, 3,554 deaths from liver cirrhosis were retrieved. The annual mortality rate was 19.8/100,000 for men and 4.31/100,000 for women, without significant changes after correction for ICD-R98 and R99 and without a significant increase in the annual percentage change. In 49% of death certificates, the aetiology of cirrhosis was defined: of these alcoholism in 81.5% of cases and viral hepatitis in 15.7%. Aetiology was confirmed in 262 reviewed records, including alcoholism (40.5%); hepatitis B or C (26.7%); other (3.8%); and cryptogenic (10.6%). The mean annual potential years of life lost were 5,946 years and 1,739 years for men and women respectively. The mortality rate from cirrhosis in Espírito Santo State is intermediate in relationship to worldwide data; alcoholism and hepatitis B or C were the main aetiologies; probably alcoholism is overestimated and hepatitis B and C viruses are underestimated as causes of cirrhosis registered on death certificates.

Spectrum of Hepatic Pathologies in Medicolegal Autopsies

“…In the present study, 12 out of 14 cases (31.58%) had history of alcohol liver disease whereas other 2 cases (25%) had history of jaundice with viral etiology. In study conducted by Goncalves et al [11] (2014), association of alcohol liver disease and cirrhosis was found to be 40.5%. In a study conducted by Nandakumar et al [12] (2003), frequency of virus induced cirrhosis was found to 25 % which is concordant with the present study (25%).…”

Perfil clínico-epidemiológico de pacientes cirróticos internados em hospital público de referência do estado de Roraima

“…A taxa alta de etiologia indefinida (27%), no material estudado, está de acordo com estudos de Sifuentes3 e Gonçalves 12 que demonstraram 37,6% e 51%, respectivamente, de cirrose hepática de causa indeterminada, estando relacionada com populações de baixa renda que não possuem recursos suficientes para exames de investigação etiológica.…”

Application of the Outcome Present State Test Model in a Patient with Liver Cirrhosis: A Case Study

“…Liver cirrhosis is the final step of a process that arises as a result of numerous diseases, especially alcoholic liver disease and viral hepatitis; in addition it is considered a major cause of death worldwide [7][8][9][10] . In Brazil, studies focused on the etiology and mortality from liver cirrhosis is scarce [10][11][12] .…”

“…In Brazil, studies focused on the etiology and mortality from liver cirrhosis is scarce [10][11][12] . However, it is known that the prevalence of liver cirrhosis has increased in the Brazilian population, especially among the elderly.…”