Mortality from lung cancer in Ontario uranium miners.

Kusiak, Robert A.; Ritchie, A. C.; Müller, Justus; Springer, Jochen

doi:10.1136/oem.50.10.920

Cited by 34 publications

(23 citation statements)

References 7 publications

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“…The Ontario uranium miners' cohort study was created to better understand the health effects associated with radon exposure following a 1974 report by Muller that observed an increased risk of lung cancer deaths among Ontario miners 19. Subsequent studies of this cohort have examined lung cancer mortality with the last follow-up from 1955 to 1986 8. However, cancer incidence has not been examined in this cohort.…”

Section: Introductionmentioning

confidence: 99%

Cancer incidence and mortality from exposure to radon progeny among Ontario uranium miners

Navaranjan

Berriault

et al. 2016

Occup Environ Med

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Section: Introductionmentioning

confidence: 99%

Cancer incidence and mortality from exposure to radon progeny among Ontario uranium miners

Navaranjan

Berriault

et al. 2016

Occup Environ Med

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“…In addition, occupational exposure to arsenic increases lung cancer incidence among smokers and underground miners, suggesting a synergistic interaction of arsenic with tobacco smoke or radon found in mines (8,9). Currently, millions of people living in India and Bangladesh are known to be exposed to arsenic through contaminated groundwater and have developed various arsenic-induced diseases.…”

Section: Introductionmentioning

confidence: 99%

Neoplastic Transformation of Human Small Airway Epithelial Cells Induced by Arsenic

Wen

Calaf

Partridge

et al. 2008

Mol Med

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Human small airway epithelial cells (SAECs) previously immortalized with human telomerase reverse transcriptase (h-TERT) were continuously treated with sodium arsenite at a dose of 0.5 μg/mL in culture for up to 6 months. Arsenic-treated cells progressively displayed an increase in transformed phenotype including enhanced growth saturation density, plating efficiency, and anchorage-independent growth and invasion capability compared with their nontreated control cells. To determine whether arsenicinduced cell transformation was associated with genomic instability, treated and control cells were also analyzed for micronuclei formation. A 4.8-fold increase in micronuclei incidence in arsenic-treated cells was detected in conjunction with increased N-phosphonacetyl-L-aspartate (PALA)-resistant characteristics. In addition, arsenic-treated cells showed an increase in c-H-ras, c-myc, and c-fos protein expression relative to controls. The change in oncoprotein expression correlated with a decrease in wildtype p53 expression and hyperphosphorylated retinoblastoma. Taken together, these results strongly suggest that h-TERT immortalized human small airway epithelial cells underwent step-wise transformation after inorganic arsenic treatment.

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“…Epidemiological studies have shown that chronic exposure to arsenic can result in liver injury, peripheral neuropathy, and an increased incidence of cancer of the lung, skin, bladder, and liver (1). In addition, occupational exposure to arsenic increases the lung cancer incidence among smokers and underground miners in a manner consistent with a synergistic interaction of arsenic with tobacco smoke or radon found in mines (2,3). Animal models are of little help in understanding its mechanism; for reasons that are not clear arsenic is not carcinogenic in rodent models.…”

mentioning

confidence: 99%

Mutagenicity of arsenic in mammalian cells: Role of reactive oxygen species

Hei

Liu²,

Waldren³

1998

Proc. Natl. Acad. Sci. U.S.A.

392

251

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Arsenite, the trivalent form of arsenic present in the environment, is a known human carcinogen that lacked mutagenic activity in bacterial and standard mammalian cell mutation assays. We show herein that when evaluated in an assay (A L cell assay), in which both intragenic and multilocus mutations are detectable, that arsenite is in fact a strong dose-dependent mutagen and that it induces mostly large deletion mutations. Cotreatment of cells with the oxygen radical scavenger dimethyl sulfoxide significantly reduces the mutagenicity of arsenite. Thus, the carcinogenicity of arsenite can be explained at least in part by it being a mutagen that depends on reactive oxygen species for its activity.

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Mortality from lung cancer in Ontario uranium miners.

Cited by 34 publications

References 7 publications

Cancer incidence and mortality from exposure to radon progeny among Ontario uranium miners

Cancer incidence and mortality from exposure to radon progeny among Ontario uranium miners

Neoplastic Transformation of Human Small Airway Epithelial Cells Induced by Arsenic

Mutagenicity of arsenic in mammalian cells: Role of reactive oxygen species

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