Mortality from myocardial infarction after adjuvant radiotherapy for breast cancer in the surveillance, epidemiology, and end-results cancer registries.

Paszat, Lawrence; Mackillop, William J.; Groome, Patti A.; Boyd, Christopher; Schulze, Karleen; Holowaty, Eric J.

doi:10.1200/jco.1998.16.8.2625

Cited by 289 publications

(142 citation statements)

References 30 publications

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“…The chronic toxicity of heart disease mortality from thoracic radiation has been studied in patients with lymphoma and breast cancer. [26][27][28] Of particular relevance to our results is a report by Giordano et al 29 suggesting that patients with breast cancer who were treated with older technology (1973)(1974)(1975)(1976)(1977)(1978)(1979) experienced an increase in radiotherapy-associated heart disease mortality compared with patients who were treated in more recent years. This finding did not begin to emerge until 10 years of follow-up had been established.…”

Section: Discussionmentioning

confidence: 49%

The risk of death from heart disease in patients with nonsmall cell lung cancer who receive postoperative radiotherapy

Lally

Detterbeck

Geiger

et al. 2007

Cancer

108

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A range of flat hot‐compacted single‐polymer composite panels made from oriented polypropylene and polyethylene with differing dynamic modulus and damping capacity were freely suspended and subjected to mechanical excitation, allowing their acoustic frequency response over the audio bandwidth to be measured. The audio response over selected bands was correlated with the dynamic modulus and damping capacity measured in bending in these materials and compared with the response of a traditional composite material, namely, carbon‐fiber‐reinforced epoxy resin. Low damping and high dynamic modulus were found to result in relatively high output levels from the hot‐compacted flat panels, which contrasted with the results previously measured on a traditional cone‐shaped speaker made from a hot‐compacted polypropylene material, which found high damping to be advantageous. The results of the current study on flat panels are explained in terms of mechanical impedance of the panels and their corresponding efficiency. It was concluded that the best flat‐panel audio response came from compacted polyethylene sheets, which combined high stiffness, low density, and a low level of damping. © 2005 Wiley Periodicals, Inc. J Appl Polym Sci, 2006

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Section: Discussionmentioning

confidence: 49%

The risk of death from heart disease in patients with nonsmall cell lung cancer who receive postoperative radiotherapy

Lally

Detterbeck

Geiger

et al. 2007

Cancer

108

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“…However, by their very nature, surrogate measurements for these risk factors are not as good as actual measurements and some residual confounding is likely. Nevertheless, in a recent review on circulatory disease and radiation effects (16), in those studies that had additional information on some of these risk factors (9,(34)(35)(36), ERR/Sv estimates were virtually unchanged when additional adjustment for these factors was made.…”

Section: Discussionmentioning

confidence: 99%

“…There is documented evidence of a dose-related excess risk of circulatory disease in Japanese atomic bomb survivors (4)(5)(6)(7). At higher, yet still moderate dose rates, studies of patients treated by radiotherapy of the left breast also demonstrate clear evidence of subsequent cardiovascular disease mortality risk several years postirradiation (8)(9)(10)(11)(12). Circulatory disease is not the only non-cancer disease that may be a late effect of radiation exposure.…”

Section: Introductionmentioning

confidence: 99%

Mortality from Circulatory System Diseases among French Uranium Miners: A Nested Case-Control Study

et al. 2015

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“…Rutqvist and Johansson (1990) reported that radiation therapy for left-sided breast cancer given in 1970 -1980 resulted in a statistically significant higher mortality due to MI. Paszat et al (1998) reported an association of radiation therapy with fatal MI in women with left-sided cancer diagnosed from 1973 -1992, particularly among women under age 60 years. Yet two studies of women treated in the 1980s reported no association of radiation therapy with MI morbidity or mortality (Hojris et al, 1999;Vallis et al, 2002).…”

Section: Discussionmentioning

confidence: 99%

Myocardial infarction risk and tamoxifen therapy for breast cancer

2005

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Tamoxifen prevents recurrence after breast cancer and breast cancer among high-risk women, and may prevent myocardial infarction (MI). To assess the impact of tamoxifen on MI risk, we conducted a case -control study of first MI after breast cancer nested among women diagnosed with breast cancer, while enrolled in a health maintenance organisation from 1980 to 2000. We obtained information on breast cancer treatment and MI risk factors through medical record reviews and interviews. Data were analysed using conditional logistic regression. Of 11 045 women with breast cancer, 134 met MI criteria and were matched to two MI-free control subjects on year of birth and breast cancer diagnosis. After adjusting for smoking, hypertension and diabetes, tamoxifen was unassociated with MI (odds ratio (OR) ¼ 1.2, 95% confidence interval (CI) ¼ 0.7 -1.9). Duration, cumulative dose and recency of use were not associated with MI. Radiation therapy was associated with MI (OR ¼ 2.0, 95% CI ¼ 1.1 -3.5), an association that varied slightly but not statistically significantly by tamoxifen use (radiation with tamoxifen, OR ¼ 2.0, 95% CI ¼ 0.9 -4.4; radiation without tamoxifen, OR ¼ 2.9, 95% CI ¼ 1.2 -7.5). Tamoxifen treatment for breast cancer does not appear to increase or decrease MI risk, although radiation therapy appears to increase MI risk.

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Mortality from myocardial infarction after adjuvant radiotherapy for breast cancer in the surveillance, epidemiology, and end-results cancer registries.

Abstract: Adjuvant RT for left-sided breast cancer diagnosed in women younger than 60 years of age is associated with a higher risk for fatal MI 10 to 15 years later compared with adjuvant RT for right-sided cases.

Cited by 289 publications

References 30 publications

The risk of death from heart disease in patients with nonsmall cell lung cancer who receive postoperative radiotherapy

The risk of death from heart disease in patients with nonsmall cell lung cancer who receive postoperative radiotherapy

Mortality from Circulatory System Diseases among French Uranium Miners: A Nested Case-Control Study

Myocardial infarction risk and tamoxifen therapy for breast cancer

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