Mortality From Pneumococcal Meningitis

Baird, Dean; Whittle, H.C.; Greenwood, Brian

doi:10.1016/s0140-6736(76)91985-1

Cited by 109 publications

(41 citation statements)

References 18 publications

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“…Previous clinical and experimental studies of pneumococcal meningitis have shown that high CSF lactate and protein concentrations and low CSF glucose concentrations are associated with severe disease [28][29][30][31][32]. By these criteria the severity of disease was markedly different in the three experimental groups in this study.…”

Section: Discussionmentioning

confidence: 51%

Differences of Pathophysiology in Experimental Meningitis Caused by Three Strains of Streptococcus Pneumoniae

Täuber

Burroughs

Niemöller

et al. 1991

Journal of Infectious Diseases

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Section: Discussionmentioning

confidence: 51%

Differences of Pathophysiology in Experimental Meningitis Caused by Three Strains of Streptococcus Pneumoniae

Täuber

Burroughs

Niemöller

et al. 1991

Journal of Infectious Diseases

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“…More importantly, the only prospective randomized study comparing single with combination therapy showed a significant reduction in morbidity and mortality in 140 patients given ampicillin, chloramphenicol and streptomycin (Mathies et al 1967). Retrospective studies, such as the present one, are obviously less satisfactory for analysing treatment but other studies have either failed to show any beneficial effect of multiple therapy (Laxer & Marks, 1977;Baird et al 1976) or have shown a detrimental effect (Lindberg et al 1977). A prospective study of the treatment of haemophilus meningitis with either chloramphenicol or ampicillin showed no difference in outcome between the two groups (Feigin et al 1976).…”

Section: Laboratory Resultsmentioning

confidence: 70%

“…The mortality from pneumococcal meningitis ranges from 13-60 % (Baird, Whittle & Greenwood, 1976) while the morbidity from Haemophilus influenzae meningitis has been reported as 35 % (Sell et al 1972) and in one American epidemic of meningococcal meningitis the mortality was 31 % (Foster, Sanders & Ginter, 1971).…”

Section: Introductionmentioning

confidence: 99%

Bacterial meningitis – ten years experience

Davey¹,

Cruikshank²,

McManus

et al. 1982

J. Hyg.

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SummaryBetween January 1968 and December 1977, 635 cases of acute bacterial meningitis were admitted to hospitals in the Birmingham Area Health Authority. The epidemiology of these cases was analysed and compared with the 270 cases which were admitted to the regional infectious diseases unit at East Birmingham Hospital (E.B.H.). In children and young adults the meningococcus was the commonest causative organism while over the age of 25 pneumococcal meningitis predominated. AlthoughHaemophilus influenzaewas the second commonest infecting organism it was a rare cause of meningitis in school children and adults, only four cases presenting in these age groups in the Birmingham Area.A detailed analysis was made of the symptoms, signs, laboratory investigations and clinical course of the 270 cases treated at E.B.H.The mortality in the patients with pneumococcal meningitis was 30%. In the meningococcal group it was 3·5% and in the haemophilus groups 7·7%.An analysis of the various treatment regimes employed in the 270 E.B.H. patients supports the view that a single antibiotic is sufficient for the therapy of most forms of bacterial meningitis. Intrathecal antibiotic administration is unnecessary in pyogenic meningitis caused by meningococci, pneumococci orH. influenzae.

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“…Elevated lactate concentrations in eSF, which appear to be only minimally influenced by direct lactate production of bacteria or leukocytes in eSF, have been associated with increased mortality from meningitis in humans [51] and in experimental pneumococcal meningitis [52].…”

Section: Discussionmentioning

confidence: 99%

Influence of Granulocytes on Brain Edema, Intracranial Pressure, and Cerebrospinal Fluid Concentrations of Lactate and Protein in Experimental Meningitis

Täuber

Borschberg²,

Sande³

1988

Journal of Infectious Diseases

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Brain water content (brain edema), intracranial pressure, and cerebrospinal fluid (CSF) concentrations of lactate and protein increased significantly during 24 h of experimental meningitis due to Streptococcus pneumoniae, but changes were similar in normal and neutropenic rabbits. In sterile meningitis induced by N-formyl-methionyl-leucyl-phenylalanine (fMLP), low and high doses of fMLP were equally effective in inducing CSF pleocytosis, whereas only high doses of fMLP caused brain edema. High doses of fMLP injected intracisternally during pneumococcal meningitis also increased brain water content. The fMLP did not significantly increase intracranial pressure or CSF concentrations of lactate or protein in sterile or pneumococcal meningitis, nor did it cause brain edema in neutropenic animals. Thus, granulocytes may contribute to brain edema during meningitis if adequately stimulated, but intracranial pressure and CSF protein and lactate concentrations appear independent of granulocytes. Stimulation does not appear to occur early in meningitis, when granulocytes were without effect on brain edema.

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Mortality From Pneumococcal Meningitis

Cited by 109 publications

References 18 publications

Differences of Pathophysiology in Experimental Meningitis Caused by Three Strains of Streptococcus Pneumoniae

Differences of Pathophysiology in Experimental Meningitis Caused by Three Strains of Streptococcus Pneumoniae

Bacterial meningitis – ten years experience

Influence of Granulocytes on Brain Edema, Intracranial Pressure, and Cerebrospinal Fluid Concentrations of Lactate and Protein in Experimental Meningitis

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