Mortality from stroke among U.S. veterans in Georgia and 5 western states: I. Study plan and death rates

Nefzger, M. Dean; Acheson, R. M.; Heyman, Albert

doi:10.1016/0021-9681(73)90092-1

Cited by 31 publications

(8 citation statements)

References 14 publications

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“…Several studies in children and adolescents, particularly the Hungarian Children's Study [40], the Moscow Children's [38], and the National Health And Nutrition Examination Survey (NHANES) [43], in the 1980s and early 1990s, demonstrated a particularly strong association between uric acid and hypertension. Studies [70][71][72][73] specifically of older and elderly patients have had more variable results, suggesting there may be a preferential effect in the young. Recent data have rekindled an interest in the link between uric acid and hypertension.…”

Section: Epidemiology Of Uric Acid and Hypertensionmentioning

confidence: 99%

Serum uric acid and the risk of hypertension and chronic kidney disease

Feig

2014

Current Opinion in Rheumatology

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Current evidence supports the role of uric acid as marker and mediator of risk for both hypertension and progressive decline in renal function. Data on the impact of xanthine oxidase inhibitors or uricosurics on clinical hypertension and chronic kidney disease are suggestive but inconclusive. Considerably, more data will be required to determine if uric acid lowering therapy will become a mainstay of management in diseases other than gout and tumor lysis syndrome.

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Section: Epidemiology Of Uric Acid and Hypertensionmentioning

confidence: 99%

Serum uric acid and the risk of hypertension and chronic kidney disease

Feig

2014

Current Opinion in Rheumatology

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“…A recent re-evaluation of the Framingham Heart Study data also suggests that higher serum uric acid levels is associated with increased risk of progression from normal blood pressure (bp) to hypertension [11]. Studies specifically of older and elderly patients have had much more variable results with regard to a link between these factors [12][13][14][15] suggesting that if uric acid leads to hypertension, there may be a preferential effect in the young.…”

mentioning

confidence: 99%

The Role of Uric Acid in Pediatric Hypertension

Feig

Johnson

2007

Journal of Renal Nutrition

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Over the past few years increasing evidence has supported the possible role of uric acid as a mediator of high blood pressure. Both animal model data and tissue culture experiments suggest that uric acid might cause increased blood pressure by a two phase process. A first phase dominated by a uric acid mediated vasoconstriction followed by induction of renal afferent arteriolosclerosis and altered pressure natriuresis leading to a sodium dependent hypertension. We have assessed children with newly diagnosed essential hypertension and through cross-sectional studies and clinical trials. Elevated uric acid is closely associated with new onset essential hypertension in children and preliminary data suggests that lowering uric acid can lower blood pressure in some patients. Future studies will be needed to determine if the mechanisms shown in animal models can be extrapolated to children.

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“…11 It is possible that some deaths may have been misclassified, but there is no reason to assume that this would apply more to one religious group than the other since no moral stigma is attached to a diagnosis of CBVD. Lower than U.S. rates have been explored by Nafzinger et al 8 and were not explainable by misclassification.…”

Section: Discussionmentioning

confidence: 99%

Cerebrovascular disease in Utah, 1968--1971.

Lyon¹,

Bishop²,

Nielsen³

1981

Stroke

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SUMMARY Utah mortality rates for cerebrorascular disease (ICD numbers 430-438) are 13% below U.S. rates. About 70% of Utahns are members of the Church of Jesus Christ of Latter-day Saints, commonly called Mormons or LDS, which proscribes use of tobacco and alcohol. Other studies on this group hare found significantly lower occurrence of many cancers and iscbemic heart disease. We tested the hypothesis that Utah's lower cerebrorascular disease (CBVD) mortality was contributed by the LDS population. We classified by religion all CBVD deaths (2,521) (except subarachnoid hemorrhage and cerebral embolism) occurring in the state in 1968-1971. No significant difference was found between LDS and non-LDS, but both groups had mortality rates below U.S. expectation. Although recent studies hare reported smoking to be a risk factor for CBVD, we found no consistent difference between the LDS and non-LDS, eren in the younger age groups. The results do not support the hypothesis that tobacco is an important etlologic agent in CBVD mortality.

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Mortality from stroke among U.S. veterans in Georgia and 5 western states: I. Study plan and death rates

Cited by 31 publications

References 14 publications

Serum uric acid and the risk of hypertension and chronic kidney disease

Serum uric acid and the risk of hypertension and chronic kidney disease

The Role of Uric Acid in Pediatric Hypertension

Cerebrovascular disease in Utah, 1968--1971.

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