Mortality in adult congenital heart disease

Verheugt, Carianne L.; Uiterwaal, Cuno S.P.M.; Velde, Enno T. van der; Meijboom, Folkert J.; Pieper, Petronella G.; Dijk, Arie P.J. van; Vliegen, Hubert W.; Grobbee, Diederick E.; Mulder, Barbara J.M.

doi:10.1093/eurheartj/ehq032

Cited by 538 publications

(313 citation statements)

References 34 publications

Supporting

Mentioning

295

Contrasting

Unclassified

Order By: Relevance

“…Adults with CHD (ACHD) have premature morbidity and mortality and often die from cardiovascular events 2. In this aging ACHD population, acquired heart disease, such as atherosclerotic coronary artery disease, may contribute to this risk.…”

Section: Introductionmentioning

confidence: 99%

Metabolic Syndrome in Adults With Congenital Heart Disease

Deen

Krieger

Slee

et al. 2016

JAHA

View full text Add to dashboard Cite

BackgroundMetabolic syndrome increases risk for atherosclerotic coronary artery disease, and its prevalence increases with increasing age and body mass index. Adults with congenital heart disease (ACHD) are now living longer and accruing coronary artery disease risk factors. However, the prevalence of metabolic syndrome in ACHD patients is unknown.Methods and ResultsWe conducted a retrospective cohort study of ACHD patients at our center to quantify the prevalence of metabolic syndrome in an ACHD population. Using case‐control matching, we constructed a comparable control group from a population‐based sample of 150 104 adults. International Diabetes Federation criteria were used to define metabolic syndrome. We used logistic regression to compare the risk of metabolic syndrome across the resulting cohorts, which were composed of 448 ACHD patients and 448 controls matched by age and sex. Mean age of both groups was 32.4±11.3 years, and 51.3% were female. Obesity was present in 16.1% of the ACHD patients and 16.7% of the controls. Metabolic syndrome was more common in ACHD patients than in controls (15.0% versus 7.4%; odds ratio 1.82, 95% CI 1.25–2.65).ConclusionsOur data suggest that metabolic syndrome is more common among adults with congenital heart disease than in the general population. Thus, patients with congenital heart disease should be screened for metabolic syndrome and risk factors mitigated where possible to prevent atherosclerotic coronary artery disease. Preventive cardiology should be included during routine ACHD care.

show abstract

Section: Introductionmentioning

confidence: 99%

Metabolic Syndrome in Adults With Congenital Heart Disease

Deen

Krieger

Slee

et al. 2016

JAHA

View full text Add to dashboard Cite

show abstract

“…The findings suggested that these GATA6 DSVs may be involved in VSD formation by changing GATA6 levels as a risk factor. As morbidity and mortality in adult CHD patients are significantly higher than general populations, likely due to genetic defects [54,55], genetic studies may provide insight into designing novel therapies for adult CHD patients.…”

Section: Discussionmentioning

confidence: 99%

Novel and functional DNA sequence variants within the GATA5 gene promoter in ventricular septal defects

et al. 2014

View full text Add to dashboard Cite

Congenital heart disease (CHD) is the most common birth defect in humans. Genetic causes and underlying molecular mechanisms for isolated CHD remain largely unknown. Studies have demonstrated that GATA transcription factor 6 (GATA6) plays an essential role in the heart development. Mutations in GATA6 gene have been associated with diverse types of CHD. As GATA6 functions in a dosage-dependent manner, we speculated that changed GATA6 levels, resulting from DNA sequence variants (DSVs) within the gene regulatory regions, may mediate the CHD development. In the present study, GATA6 gene promoter was genetically and functionally analyzed in large groups of patients with ventricular septal defect (VSD) (n = 359) and ethnic-matched healthy controls OPEN ACCESS Int. J. Mol. Sci. 2014, 15 12678(n = 365). In total, 11 DSVs, including four SNPs, were identified in VSD patients and controls. Two novel and heterozygous DSVs, g.22169190A>T and g.22169311C>G, were identified in two VSD patients, but in none of controls. In cultured cardiomyocytes, the activities of the GATA6 gene promoter were significantly reduced by the DSVs g.22169190A>T and g.22169311C>G. Therefore, our findings suggested that the DSVs within the GATA6 gene promoter identified in VSD patients may change GATA6 levels, contributing to the VSD development as a risk factor.

show abstract

“…This suggests that the patients in the 30-50 year old group had selected themselves by having mild forms of septal defects without the added comorbidities of older age. Verheugt et al [4] investigated the causes of mortality in this unique patient population by linking the Dutch national registry for ACHD patients with the national death registry between the years 2002-2009. They found excessive mortality associated with ACHD when compared to the general population.…”

Section: Peri Procedural Risk Assessment and Stratificationmentioning

confidence: 99%

Perioperative Care of Adults with Congenital Heart Disease for Non-cardiac Surgery

Howard‐Quijano

Smith

Schwarzenberger

2013

Curr Anesthesiol Rep

View full text Add to dashboard Cite

In 2010 it was estimated that 1.2 million young adults in the United States have some form of congenital heart disease (CHD). Data from large adult congenital heart disease (ACHD) centers show that as many as 50 % of these patients are over 40 years of age. As this population ages, physicians are likely to encounter such patients in their practice. Risk stratification and an interdisciplinary approach are paramount in achieving safe outcomes. The assessment of the patient must consider the variable expression of CHD. As most lesions are ''fixed but not cured'' the altered physiology of the heart and the physiological challenges of surgical interventions must be considered. The 2008 AHA/ACC guidelines for the Management of Adults with CHD establish for the first time a streamlined approach to the care of these patients. This review will apply these guidelines to the ACHD patient undergoing non-cardiac surgery.

show abstract

Mortality in adult congenital heart disease

Cited by 538 publications

References 34 publications

Metabolic Syndrome in Adults With Congenital Heart Disease

Metabolic Syndrome in Adults With Congenital Heart Disease

Novel and functional DNA sequence variants within the GATA5 gene promoter in ventricular septal defects

Perioperative Care of Adults with Congenital Heart Disease for Non-cardiac Surgery

Contact Info

Product

Resources

About