Mortality in COVID-19 disease patients: Correlating the association of major histocompatibility complex (MHC) with severe acute respiratory syndrome 2 (SARS-CoV-2) variants

Sousa, Eric de; Ligeiro, Dário; Lérias, Joana R.; Zhang, C; Agrati, Chiara; Osman, Mohamed; El‐Kafrawy, Sherif A.; Azhar, Esam I.; Ippolito, Giuseppe; Wang, Fu Sheng; Zumla, Alimuddin; Maeurer, Markus

doi:10.1016/j.ijid.2020.07.016

Cited by 54 publications

(59 citation statements)

References 48 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…MHC class I and II loci were associated with different coronavirus infections and their outcomes in poultry [ 28 ]. Associations with MHC loci and mortality in COVID-19 was recently reported [ 29 ].…”

Section: Discussionmentioning

confidence: 99%

Candidate Gene Markers Associated with Fecal Shedding of the Feline Enteric Coronavirus (FECV)

et al. 2020

View full text Add to dashboard Cite

The Feline coronavirus (FCoV) can cause a fatal disease, the Feline Infectious Peritonitis. Persistent shedders represent the most important source of infection. The role of the host in FCoV fecal shedding is unknown. The objective of this study was to develop gene markers and to test their associations with FCoV shedding patterns. Fecal samples were taken from 57 cats of 12 breeds on the day 0 and after 2, 4 and 12 months. Variation from persistent and/or high-intensity shedding to no shedding was observed. Thirteen immunity-related genes were selected as functional and positional/functional candidates. Positional candidates were selected in a candidate region detected by a GWAS analysis. Tens to hundreds of single nucleotide polymorphisms (SNPs) per gene were identified using next generation sequencing. Associations with different phenotypes were assessed by chi-square and Fisher’s exact tests. SNPs of one functional and one positional candidate (NCR1 and SLX4IP, respectively) and haplotypes of four genes (SNX5, NCR2, SLX4IP, NCR1) were associated with FCoV shedding at pcorected < 0.01. Highly significant associations were observed for extreme phenotypes (persistent/high-intensity shedders and non-shedders) suggesting that there are two major phenotypes associated with different genotypes, highly susceptible cats permanently shedding high amounts of viral particles and resistant non-shedders.

show abstract

Section: Discussionmentioning

confidence: 99%

Candidate Gene Markers Associated with Fecal Shedding of the Feline Enteric Coronavirus (FECV)

et al. 2020

View full text Add to dashboard Cite

show abstract

“…The severity of the current COVID-19 pandemic caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) relative to past outbreaks of Middle East respiratory syndrome, SARS, and other betacoronaviruses in humans begs the question as to its molecular basis. The accessory protein ORF8 is one of the most rapidly evolving betacoronavirus proteins ( 1 – 7 ). While ORF8 expression is not strictly essential for SARS-CoV and SARS-CoV-2 replication, a 29-nucleotide deletion (Δ29) that occurred early in human to human transmission of SARS-CoV, splitting ORF8 into ORF8a and ORF8b, is correlated with milder disease ( 8 ).…”

mentioning

confidence: 99%

Structure of SARS-CoV-2 ORF8, a rapidly evolving immune evasion protein

Flower

Buffalo

Hooy

et al. 2020

Proc. Natl. Acad. Sci. U.S.A.

226

261

View full text Add to dashboard Cite

The molecular basis for the severity and rapid spread of the COVID-19 disease caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is largely unknown. ORF8 is a rapidly evolving accessory protein that has been proposed to interfere with immune responses. The crystal structure of SARS-CoV-2 ORF8 was determined at 2.04-Å resolution by X-ray crystallography. The structure reveals a ∼60-residue core similar to SARS-CoV-2 ORF7a, with the addition of two dimerization interfaces unique to SARS-CoV-2 ORF8. A covalent disulfide-linked dimer is formed through an N-terminal sequence specific to SARS-CoV-2, while a separate noncovalent interface is formed by another SARS-CoV-2−specific sequence, 73YIDI76. Together, the presence of these interfaces shows how SARS-CoV-2 ORF8 can form unique large-scale assemblies not possible for SARS-CoV, potentially mediating unique immune suppression and evasion activities.

show abstract

“…A targeted approach in generating both cell-mediated immune response and antibody production by introducing viral proteins is considered the most effective vaccination strategy against COVID-19. The S and N proteins of SARS-CoV-2 are short-lived and are associated with major histocompatibility complex (MHC) in the human population [81] . These, along with many B-cell epitopes identified on S protein domains, indicate possible access to antibodies following virus-host interaction.…”

Section: Resultsmentioning

confidence: 99%

A rapid review of recent advances in diagnosis, treatment and vaccination for COVID-19

Umakanthan

Chattu

Ranade³

et al. 2021

AIMS Public Health

View full text Add to dashboard Cite

COVID-19 is caused by SARS-CoV-2, which originated in Wuhan, Hubei province, Central China, in December 2019 and since then has spread rapidly, resulting in a severe pandemic. The infected patient presents with varying non-specific symptoms requiring an accurate and rapid diagnostic tool to detect SARS-CoV-2. This is followed by effective patient isolation and early treatment initiation ranging from supportive therapy to specific drugs such as corticosteroids, antiviral agents, antibiotics, and the recently introduced convalescent plasma. The development of an efficient vaccine has been an on-going challenge by various nations and research companies. A literature search was conducted in early December 2020 in all the major databases such as Medline/PubMed, Web of Science, Scopus and Google Scholar search engines. The findings are discussed in three main thematic areas namely diagnostic approaches, therapeutic options, and potential vaccines in various phases of development. Therefore, an effective and economical vaccine remains the only retort to combat COVID-19 successfully to save millions of lives during this pandemic. However, there is a great scope for further research in discovering cost-effective and safer therapeutics, vaccines and strategies to ensure equitable access to COVID-19 prevention and treatment services.

show abstract

Mortality in COVID-19 disease patients: Correlating the association of major histocompatibility complex (MHC) with severe acute respiratory syndrome 2 (SARS-CoV-2) variants

Cited by 54 publications

References 48 publications

Candidate Gene Markers Associated with Fecal Shedding of the Feline Enteric Coronavirus (FECV)

Candidate Gene Markers Associated with Fecal Shedding of the Feline Enteric Coronavirus (FECV)

Structure of SARS-CoV-2 ORF8, a rapidly evolving immune evasion protein

A rapid review of recent advances in diagnosis, treatment and vaccination for COVID-19

Contact Info

Product

Resources

About