Mortality in patients with coeliac disease and their relatives: a cohort study

Corrao, Giovanni; Corazza, Gino Roberto; Bagnardi, Vincenzo; Brusco, G.; Ciacci, Carolina; Cottone, Mario; Guidetti, Carla Sategna; Usai, Paolo; Cesari, P.; Pelli, Maria Antonietta; Loperfido, Silvano; Volta, Umberto; Calabrò, Antonino; Certo, Maria Grazia Di

doi:10.1016/s0140-6736(01)05554-4

Cited by 538 publications

(439 citation statements)

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“…It has been known for some time that the risk of complications in patients with CD is linked to a series of factors such as age at diagnosis of CD, the diagnostic delay of CD, the strictness of the gluten-free diet, the clinical form of CD and the homozygosity for DQ2 [2,18,[23][24][25][26]. Our results confirmed a strong correlation between age at diagnosis of CD and the risk of developing a complicated form of CD.…”

Section: Discussionsupporting

confidence: 83%

“…Although it has been known for many years that the increased mortality in CD is due to its feared complications [23], the literature reports very few epidemiological data on these complications [8,[15][16][17][18][19]. This lack of data can undoubtedly be attributed both to the significant selection biases in these series of patients and to the difficulties caused by the lack of uniform diagnostic criteria for the various forms of CCD [15,16].…”

Section: Discussionmentioning

confidence: 99%

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Low incidence but poor prognosis of complicated coeliac disease: A retrospective multicentre study

Biagi

Gobbi

Marchese

et al. 2014

Digestive and Liver Disease

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Section: Discussionsupporting

confidence: 83%

Section: Discussionmentioning

confidence: 99%

Low incidence but poor prognosis of complicated coeliac disease: A retrospective multicentre study

Biagi

Gobbi

Marchese

et al. 2014

Digestive and Liver Disease

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“…Celiac disease identified in adulthood is associated with a 1.3 to 2.0 fold mortality of that of the general population (3,44,45), but this is due primarily to malignancy occurring within the first two years of diagnosis.…”

Section: Consequences Of Untreatedmentioning

confidence: 99%

Practical considerations for the identification and follow-up of children with celiac disease

Dirks

2004

Paediatrics &Amp; Child Health

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Celiac disease is an immune-mediated enteropathy affecting 0.5% to 1% of children and is induced by dietary gluten in susceptible individuals carrying the human leukocyte antigen DQ2 or DQ8 heterodimer. If serological screening is positive or if a patient displays suggestive symptoms, an endoscopic biopsy of the distal duodenum is required to confirm the diagnosis. Symptoms of celiac disease are often mild or absent. Overt malabsorption occurs in only 2% to 10% of children. Individuals with a higher risk of developing celiac disease, including first-degree relatives of affected patients and children with type I diabetes, Turner syndrome, Williams syndrome or Down syndrome, should be offered screening for celiac disease along with a discussion of the implications. If serological testing is negative, a high index of suspicion should remain if malabsorption, iron deficiency or osteopenia is present. Also, immunoglobulin A deficiency should be excluded. At-risk individuals should undergo serial serological screening. Lifelong adherence to a gluten-free diet is the only treatment. If left untreated, symptomatic children with celiac disease carry an increased risk of developing osteoporosis and have a greater lifetime risk of cancer. The long-term outcome of undiagnosed or untreated asymptomatic individuals is less clear.Key Words: Celiac disease; Gluten-free diet; Gluten-sensitive enteropathy; IgA deficiency; Tissue transglutaminase; Type I diabetes Des considérations pratiques pour dépister et suivre les enfants atteints d'une maladie coeliaqueLa maladie coeliaque est une entéropathie d'origine immunologique qui touche de 0,5 % à 1,0 % des enfants et qui est induite par le gluten diététique chez des individus susceptibles porteurs de l'antigène HLA DQ2 ou DQ8 hétérodimère. Si le dépistage sérologique est positif ou si un patient présente des symptômes évocateurs, une biopsie endoscopique du duodénum distal s'impose pour confirmer le diagnostic. Les symptômes de maladie coeliaque sont souvent légers ou inexistants. Une malabsorption patente ne s'observe que chez 2 % à 10 % des enfants. Les individus plus vulnérables à la maladie coeliaque, y compris les parents au premier degré des patients atteints et les enfants souffrant

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“…Importantly, at this stage, the gluten-free diet is not anymore able to control the disease making this end point of CD an untreatable disease, which leads to death of the patients. 53 These patients while not responsive to gluten-free diet are celiac patients as they have the genetic (HLA DQ2), serology (anti-tTG …”

Section: Gene Therapy In Celiac Diseasementioning

confidence: 99%