Mortality in schizophrenia and schizoaffective disorder: An Olmsted County, Minnesota cohort: 1950–2005

Capasso, Rebecca; Lineberry, Timothy W.; Bostwick, John; Decker, Paul A.; Sauver, Jennifer L. St.

doi:10.1016/j.schres.2007.10.005

Cited by 184 publications

(122 citation statements)

References 37 publications

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“…The high rates of MetS in patients with schizophrenia and specifically patients treated with SGA should be a concern to clinicians because of the trend of still increasing premature mortality due to cardiovascular illness in people with schizophrenia while the risk for cardiovascular mortality in the general population continues to go down (Brown et al, 2000;Capasso et al, 2008;Hennekens et al, 2005, Joukamaa et al, 2001Osby et al, 2000a,b;Osby, 2007).…”

Section: Discussionmentioning

confidence: 99%

Typical and Atypical Antipsychotics Differentially Affect Long-Term Incidence Rates of the Metabolic Syndrome in First-Episode Patients With Schizophrenia: A Retrospective Chart Review

Hert¹,

Winkel²,

Schreurs³

et al. 2008

Schizophrenia Research

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The presence of the metabolic syndrome (MetS) is an important risk factor for cardiovascular disease and diabetes. There are limited data on the prevalence of MetS in patients with schizophrenia at the onset of the disorder and specifically no data on patients treated in the era when only first-generation antipsychotics were available.Methods: Data from a historic cohort of consecutively admitted first-episode patients with schizophrenia treated with first-generation antipsychotics (FGAs) were compared with an age and sex matched series of consecutive first-episode patients treated only with second-generation antipsychotics (SGAs). Rates of MetS were compared at baseline and after on average 3 years of treatment exposure.Results: At first episode there was no difference in the prevalence of MetS between the historic and the current cohort. Rates of MetS increased over time in both groups, but patients started on SGAs had a three times higher incidence rate of MetS (Odds Ratio 3.6, CI 1.7-7.5). The average increase in weight and body mass index was twice as high in patients started on SGA. The difference between the FGA and SGA group was no longer significant when patients started on clozapine and olanzapine were excluded. Conclusion:Rates of MetS at the first episode of schizophrenia today are not different from those of patients 15 to 20 years ago. This finding counters the notion that the high rates of metabolic abnormalities in patients with schizophrenia currently reported are mainly due to lifestyle changes over time in the general population. Some SGAs have a significantly more negative impact on the incidence of MetS compared to FGAs in first-episode patients.

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Section: Discussionmentioning

confidence: 99%

Typical and Atypical Antipsychotics Differentially Affect Long-Term Incidence Rates of the Metabolic Syndrome in First-Episode Patients With Schizophrenia: A Retrospective Chart Review

Hert¹,

Winkel²,

Schreurs³

et al. 2008

Schizophrenia Research

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“…This is linked to several diseases, which reduces their life expectancy by approximately 20 years less than the general population [59][60][61]. Although still little is known about the benefits of exercise on mental health, cognition and brain activity of schizophrenic patients, exercise training has been shown to be a very beneficial intervention in the control and reduction of disease severity.…”

Section: Resultsmentioning

confidence: 99%

Effects of Exercise on Physical and Mental Health, and Cognitive and Brain Functions in Schizophrenia: Clinical and Experimental Evidence

Rimes¹,

Moura²,

Lamego³

et al. 2015

CNSNDDT

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Exercise promotes several health benefits, such as cardiovascular, musculoskeletal and cardiorespiratory improvements. It is believed that the practice of exercise in individuals with psychiatric disorders, e.g. schizophrenia, can cause significant changes. Schizophrenic patients have problematic lifestyle habits compared with general population; this may cause a high mortality rate, mainly caused by cardiovascular and metabolic diseases. Thus, the aim of this study is to investigate changes in physical and mental health, cognitive and brain functioning due to the practice of exercise in patients with schizophrenia. Although still little is known about the benefits of exercise on mental health, cognitive and brain functioning of schizophrenic patients, exercise training has been shown to be a beneficial intervention in the control and reduction of disease severity. Type of training, form of execution, duration and intensity need to be better studied as the effects on physical and mental health, cognition and brain activity depend exclusively of interconnected factors, such as the combination of exercise and medication. However, one should understand that exercise is not only an effective nondrug alternative, but also acts as a supporting linking up interventions to promote improvements in process performance optimization. In general, the positive effects on mental health, cognition and brain activity as a result of an exercise program are quite evident. Few studies have been published correlating effects of exercise in patients with schizophrenia, but there is increasing evidence that positive and negative symptoms can be improved. Therefore, it is important that further studies be undertaken to expand the knowledge of physical exercise on mental health in people with schizophrenia, as well as its dose-response and the most effective type of exercise.

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“…Bu sonucun; ruhsal hastal›¤›n meydana getirdi¤i olumsuz durumlardan, psikotrop ilaçlar›n etkisi ve bazen de mevcut hastal›¤›n klini¤i nedeniyle di¤er hastal›klar›n atlanabilmesinden kaynakland›¤› düflü-nülmektedir. Ayr›ca flizofrenik hastalarda normal popü-lasyona göre daha s›k görülen do¤al kökenli hastal›klar (kardiyovasküler, serebrovasküler ve respiratuar sistem hastal›klar›) ile intihar orijinliler baflta olmak üzere do¤al olmayan ölümlerin de bu oran›n artmas›nda etkili oldu¤u bildirilmifltir (1)(2)(3)(4)(5).…”

Section: G‹r‹fi Ve Amaçunclassified

Akıl Hastalarında Önyargılar Nedeniyle Tanısı Geçirebilen Veya Atlanabilen Hastalıklar İki Olgu Sunumu

Arslan¹,

Eren²,

Çekin³

2008

Bull Leg Med

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SUMMARYPatients with psychiatric diseases have higher levels of mortality compared to the normal population. Because underlying diseases could be overlooked due to negative emotional status, the effects of phsycotropic drugs and clinical progression of the current disease. In the current study, we presented two cases in which two schizophrenic patients died because of overlooked organic diseases like late-diagnosed blunt head trauma and undiagnosed acute abdomen.The first case was a schizophrenic 37 years-old male. It was reported that the patient was taken to Psychiatry Hospital because he was incooperable and his general status was poor. It was also notified that he fell to the ground because of diffuculty in walking, an abrasion occurred in right eyebrow, he developed confussion in the 2nd day of the accident, had acute subdural and subarachnoid bleeding in the 4th day, was operated and then died 4 days after the operation. In his autopsy, a lineer fracture in right anterior fossa and subdural and subarachnoidal bleedings were detected. Finally the patient was reported to die from cerebral hemorrhage due to blunt skull trauma.

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Mortality in schizophrenia and schizoaffective disorder: An Olmsted County, Minnesota cohort: 1950–2005

Cited by 184 publications

References 37 publications

Typical and Atypical Antipsychotics Differentially Affect Long-Term Incidence Rates of the Metabolic Syndrome in First-Episode Patients With Schizophrenia: A Retrospective Chart Review

Typical and Atypical Antipsychotics Differentially Affect Long-Term Incidence Rates of the Metabolic Syndrome in First-Episode Patients With Schizophrenia: A Retrospective Chart Review

Effects of Exercise on Physical and Mental Health, and Cognitive and Brain Functions in Schizophrenia: Clinical and Experimental Evidence

Akıl Hastalarında Önyargılar Nedeniyle Tanısı Geçirebilen Veya Atlanabilen Hastalıklar İki Olgu Sunumu

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