Mortality of Bullous Skin Disorders From 1979 Through 2002 in the United States

Risser, Jessica; Lewis, Kevan G.; Weinstock, Martin A.

doi:10.1001/archdermatol.2009.205

Cited by 52 publications

(34 citation statements)

References 21 publications

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“…Otoimmün büllü hastalıklarda mortalite araştırıldığında Risser ve ark. 'nın 1979 ile 2002 yılları arasında büllü hastalık mortalite oranını değerlendirdikleri çalışmalarında büllü hastalıklar içinde 1979 yılından 2002 yılına kadar mortalite oranının stabil kaldığını, bu period süresince pemfigoidde mortalite oranı artarken, pemfigusta düştüğünü tespit etmişlerdir 33 . Uzun ve ark.…”

Section: Türk Dermunclassified

Otoimmün büllü hastalıkların klinik ve demografik özellikleri: 85 hastanın retrospektif analizi

Gül¹,

Kılıç²,

Çakmak³

et al. 2014

TURKDERM

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ÖzetAmaç: Otoimmün büllü hastalıklar, derideki spesifik antijenlere yönelik dokuda ya da kanda otoantikorların varlığı ile karakterize deri ve/veya mukoza tutulumu ile seyreden hastalıklar grubudur. Çalışmamızın amacı kliniğimize başvuran otoimmün büllü hastalıkların demografik ve klinik özelliklerini değerlendirmektir. Yöntem ve Gereçler: 2003-2011 yılları arasında kliniğimize başvuran klinik, histopatolojik ve immunopatolojik kriterlere dayanılarak otoimmün büllü hastalıklar tanısı konan hastalar retrospektif olarak değerlendirildi. Olgular; cinsiyetleri, yaşları, otoimmün büllü hastalık tanısı, lezyonların başlangıç zamanı ve lokalizasyonu, tutulum yaygınlığı, eşlik eden hastalıklar, hastaların aldığı tedavi, tedaviye yanıtları açısından değerlendirildi. Bulgular: Çalışmamıza toplam 85 hasta alındı. Hastaların 49'u kadın (%57,64), 36'sı erkekti (%42,36). Olguların 57'si (%67,05) pemfigus (P), 24'ü ise (%28,23) pemfigoid grubundaydı. Pemfigus vulgarisli olguların büllöz pemfigoidli olgulara oranı 3,16 olarak saptandı. Lezyonların başlangıç yaşları 22 ile 82 arasında değişiyordu ve kronisitesi 2 hafta ile 120 ay arasında değişiyordu. Olguların takipleri sırasında pemfigus vulgarisli bir olguya mide kanseri tanısı konuldu. Büllöz pemfigoidli üç olguda malinite eşlik ediyordu: Bir olgu kemik metastazlı opere meme karsinomu, bir olgu renal karsinoma ve bir olguda lenfoma mevcut idi. Bir olgu hariç tüm olgularımız klasik tedaviye yanıt verdi. Sonuç: Çalışmamızda en sık pemfigus vulgarise rastladık, ancak pemfigus/büllöz pemfigoid oranını ise daha önceki çalışmalara göre daha düşük saptadık. Ayrıca otoimmün büllü hastalıkların çeşitli hastalıklarla birlikte görülebilme ihtimali nedeniyle detaylı araştırılmaları gerektiğini vurgulamak istiyoruz. (Türk derm 2014; 48: 7-12) Anah tar Ke li me ler: Pemfigus vulgaris, büllöz pemfigoid, otoimmün büllü hastalık Sum maryBackground and Design: Autoimmune bullous dermatoses are a group of diseases characterized by the presence of autoantibodies in tissue or blood against specific cutaneous antigens. The aim of our study was to evaluate the demographical and clinical features of patients with autoimmune bullous diseases who applied to our clinic. Materials and Methods: We retrospectively analyzed the patients who were diagnosed with autoimmune bullous diseases according to clinical, histopathological and immunopathological criteria between the years 2003 and 2011. The subjects were evaluated according to their sex, age, the type of autoimmune bullous disease, the onset and localization of lesions, the extensity of involvement, associated diseases, the treatment they were given and the response to the treatment. Results: A total of 85 cases were included in our study. Fourty-nine (57.64%) patients were female, 36 (42.36%) were male. Fifty-seven cases (67.05%) belonged to pemphigus (P) group and 24 (28.23%) to pemphigoid. The ratio of patients with pemphigus vulgaris to the patients with pemphigoid was found to be 3.16. The age range of the onset of the symptoms was between 22 an...

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Section: Türk Dermunclassified

Otoimmün büllü hastalıkların klinik ve demografik özellikleri: 85 hastanın retrospektif analizi

Gül¹,

Kılıç²,

Çakmak³

et al. 2014

TURKDERM

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“…The clinical course of BP is highly variable and may result in a chronically recurrent representation [23][24][25][26] . Although BP is a potentially fatal disease, the exact mortality figures are unknown.…”

Section: Prognosismentioning

confidence: 99%

Bullous pemphigoid appearing as superficial tissue necrosis after irradiation of the breast: Case history and definitive review of the literature

Trombetta

Erb²,

Kudithipudi

et al. 2015

JST

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Bullous pemphigoid is an unusual condition that occurs rarely as a complication following radiotherapy. Because of the difficulties in the diagnosis of this disease and the need for raising awareness of such as a complication of therapeutic intervention we present a case report and review of the literature with discussion to highlight this disease which can confound the management of breast cancer. Key wordsRadiation, Bullous pemphigoid, Breast cancer, Necrosis, Skin Case presentationA 73-year-old fair-skinned Caucasian female presented for a routine screening mammogram in July of 2012 which demonstrated a suspicious 1.0 cm spiculated solid density in the central region of the left breast. The Breast Imaging Reporting and Data System (BI-RADS) category was assessed as 4. Immediately following the mammogram, the patient underwent a core needle biopsy under stereotactic guidance which revealed a moderately differentiated estrogen and progesterone positive invasive ductal carcinoma. Her 2 neu was not overexpressed and the Ki 67 ratio was 22%. The patient underwent a left sided needle localized lumpectomy and sentinel node biopsy. The final pathology demonstrated a 0.8 cm lesion downgraded to low grade differentiation with negative resection margins. In addition, a small component of ductal carcinoma in-situ was identified in the specimen. No comedonecrosis was identified. The final margins of resection were clear with greater than 0.2 cm circumferentially uninvolved. None of the three sentinel lymph nodes was positive for malignancy. A metastatic work up including a comprehensive metabolic panel, a chest x-ray and routine hematologic indices was within normal limits. Her physical exam demonstrated no abnormalities. The patient had a past medical history significant for essential hypertension, fibrocystic breast change, gastro-esophageal reflux, osteoporosis and benign ovarian cysts. She had no appreciable family history of cancer and used hydrochlorothiazide, esomeprazole, and amlodipine. She was allergic to penicillin, sulfa compounds and codeine. She received 4256 cGy at 266 cGy per fraction to the right breast, completing such in October of the same year. During radiotherapy, the patient developed grade I erythema

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“…1,3 Death may occur during infancy or early childhood due to sepsis, renal failure, upper airway occlusion, or failure to thrive (due to oesophageal stricture). 5,6 Skin biopsy light microscopy examination in EBS reveals separation and blister formation in the epidermal layer (keratinocytes). Examination by immunofluorescent antibody/antigen mapping is the sine qua non for the diagnosis of EBS because of its rapid turnaround time, and high sensitivity and specificity.…”

Section: Case Reportmentioning

confidence: 99%

Epidermolysis bullosae

An¹

2011

Medical Journal Armed Forces India

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normal. A clinical diagnosis of EBS was made. Screening test for congenital syphilis was negative. Skin biopsy (using electron microscopy) from the edge of affected lesion confirmed it to be EBS. There was no similar family history in the past. Supportive management in the form of skin dressing, puncture of blisters, local antiseptic application and careful handling was done. Complete breast feeds was started and genetic counselling was done. The baby is progressing well on regular OPD follow-up. DISCUSSIONEpidermolysis bullosae is a genetic disorder caused by a mutation in the keratin gene. The identified genes include those that encode keratins 5 and 14 in EBS (autosomal recessive), collagen VII in DEB (autosomal recessive and dominant types), and

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Mortality of Bullous Skin Disorders From 1979 Through 2002 in the United States

Cited by 52 publications

References 21 publications

Otoimmün büllü hastalıkların klinik ve demografik özellikleri: 85 hastanın retrospektif analizi

Otoimmün büllü hastalıkların klinik ve demografik özellikleri: 85 hastanın retrospektif analizi

Bullous pemphigoid appearing as superficial tissue necrosis after irradiation of the breast: Case history and definitive review of the literature

Epidermolysis bullosae

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