Mortality of cancer patients with septic shock: a nation-based cohort analysis in 77,888 patients

Abstract

Purpose: Septic shock and cancer occur routinely in intensive care unit patients. Our aim was to determine the 90-day mortality rate of patients with septic shock and solid cancer or hematological cancer. Methods: We performed a retrospective cohort study using data from the French national hospitalization database, including adult patients with septic shock from 2017 to 2018. Primary outcomes were the hospital mortality rate at 90 days in patients with solid cancer and hematological cancer. Secondary outcomes were the risk factors associated with mortality in our global cohort. Results: Septic shock was found in 77,888 patients, including 19,329 patients with solid cancer, 6,498 with hematological cancer and 52,061 noncancer patients. Patients with solid cancer (adjusted hazard ratio 1.55 [1.51-1.59]) and hematological cancer (1.59 [1.53-1.65]) had increased risk of 90-day mortality, as compared with noncancer patients. Risk factors for 90-days hospital mortality included hematological cancer and solid cancer. Conclusion: Our study showed that solid cancer and hematological cancer differed in terms of 90-days mortality in septic shock patients. Future investigations are required to assess the interplay between cancer and septic shock.