Mortality of necrotizing enterocolitis expressed by birth weight categories

Fitzgibbons, Shimae; Ching, Y. Avery; Yu, David C.; Carpenter, Joseph A.; Kenny, Michael; Weldon, Christopher B.; Lillehei, C. Walton; Valim, Clarissa; Horbar, Jeffrey D.; Jaksic, Tom

doi:10.1016/j.jpedsurg.2009.02.013

Cited by 525 publications

(364 citation statements)

References 13 publications

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“…NEC is a life-threatening GI tract illness, causing necrosis of the intestine and can affect other organs of the body, including the brain with subsequent consequences which are far worse than the damage to the GI tract. NEC affects 5-10% of infants born with a birth-weight of less than 1500 g and despite advances in neonatal care is fatal in up to 30% of cases (Fitzgibbons et al, 2009) and associated with long-term intellectual disability. Recently, the use of probiotics in the treatment of NEC has been advocated (Embleton and Yates, 2008;Mshvildadze and Neu, 2009;Gareau et al, 2010).…”

Section: Gut Microbiota Establishmentmentioning

confidence: 99%

Microbes, Immunity, and Behavior: Psychoneuroimmunology Meets the Microbiome

Dinan

Cryan

2016

Neuropsychopharmacol

201

121

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There is now a large volume of evidence to support the view that the immune system is a key communication pathway between the gut and brain, which plays an important role in stress-related psychopathologies and thus provides a potentially fruitful target for psychotropic intervention. The gut microbiota is a complex ecosystem with a diverse range of organisms and a sophisticated genomic structure. Bacteria within the gut are estimated to weigh in excess of 1 kg in the adult human and the microbes within not only produce antimicrobial peptides, short chain fatty acids, and vitamins, but also most of the common neurotransmitters found in the human brain. That the microbial content of the gut plays a key role in immune development is now beyond doubt. Early disruption of the host-microbe interplay can have lifelong consequences, not just in terms of intestinal function but in distal organs including the brain. It is clear that the immune system and nervous system are in continuous communication in order to maintain a state of homeostasis. Significant gaps in knowledge remain about the effect of the gut microbiota in coordinating the immune-nervous systems dialogue. However, studies using germ-free animals, infective models, prebiotics, probiotics, and antibiotics have increased our understanding of the interplay. Early life stress can have a lifelong impact on the microbial content of the intestine and permanently alter immune functioning. That early life stress can also impact adult psychopathology has long been appreciated in psychiatry. The challenge now is to fully decipher the molecular mechanisms that link the gut microbiota, immune, and central nervous systems in a network of communication that impacts behavior patterns and psychopathology, to eventually translate these findings to the human situation both in health and disease. Even at this juncture, there is evidence to pinpoint key sites of communication where gut microbial interventions either with drugs or diet or perhaps fecal microbiota transplantation may positively impact mental health.

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Section: Gut Microbiota Establishmentmentioning

confidence: 99%

Microbes, Immunity, and Behavior: Psychoneuroimmunology Meets the Microbiome

Dinan

Cryan

2016

Neuropsychopharmacol

201

121

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“…The disease is characterized by intestinal necrosis and leads to multiple organ failure 1 . The mortality rate associated with NEC ranges from 20 to 30%, with gastrointestinal sequelae such as stenosis and short bowel syndrome possibly being present in cases in which there is resolution or the need for surgical intervention 2 . The physiopathological events of the disease are still unknown, but their origin appears to be multifactorial.…”

Section: Introductionmentioning

confidence: 99%

L-FABP and I-FABP expression in newborn rats changes inversely in the model of necrotizing enterocolitis

et al. 2014

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Brazil. Mentor, conception and design of the study, manuscript writing and critical revision. ABSTRACT PURPOSE:To determine the expression of hepatic L-FABP and intestinal I-FABP in an experimental model of necrotizing enterocolitis (NEC) in neonatal rats. METHODS:Newborn Sprague-Dawley rats were divided into four groups: Control (C1) -exclusive breastfeeding at the first and sixth procedures (C6), NEC1 -fed formula milk and submitted to hypoxia and hypothermia at the first and sixth procedures (NEC6). The newborn pups were fed twice a day for three days, for a total of six procedures. Samples were collected for morphometric evaluation (body weight, liver weight, liver weight/body weight ratio, intestinal weight and intestinal/body weight ratio) and for immunohistochemical and Western blotting analysis. The values obtained were analyzed statistically, with the level of significance set at p<0.05. RESULTS:Morphometric measurements showed reduction of body and liver weights in the NEC group (p<0.05). Both immunohistochemistry and western blotting revealed that L-FABP expression in the liver was decreased and I-FABP expression in the ileum was increased in the NEC group (p<0.05).CONCLUSION: L-FABP and I-FABP expression changed inversely in the rat NEC model. These findings can contribute to a better diagnosis of NEC in human newborns.

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“…НЭК -тяжелое заболевание периода новорожденности, инфек-ционно-воспалительной этиологии, вызванное гипокси-чески-ишемическим повреждением, образованием язв и некрозом кишечной стенки [26]. Частота НЭК в среднем составляет 1-5 случаев на 1000 новорожденных детей, родившихся живыми, среди них 80-90% составляют глу-боко недоношенные дети [27].…”

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Impact of Early-Life Microbiota on the Development of Infants

Пахомовская¹,

Venediktova²

2018

Med. sov.

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Mortality of necrotizing enterocolitis expressed by birth weight categories

Cited by 525 publications

References 13 publications

Microbes, Immunity, and Behavior: Psychoneuroimmunology Meets the Microbiome

Microbes, Immunity, and Behavior: Psychoneuroimmunology Meets the Microbiome

L-FABP and I-FABP expression in newborn rats changes inversely in the model of necrotizing enterocolitis

Impact of Early-Life Microbiota on the Development of Infants

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