Mortality of newly diagnosed heart failure treated with amiodarone

2016 ESC Guidelines for the Diagnosis and Treatment of Acute and Chronic Heart Failure

“…• IHD (unless they have had an MI in the prior 40 days -see below 242,243 contemporary studies conducted since the widespread introduction of beta-blockers suggest that it does not reduce mortality in patients with HFrEF. 227,244,245 Dronedarone 246,247 and class I antiarrhythmic agents 246,248 should not be used for prevention of arrhythmias in this population.…”

2016 ESC Guidelines for the diagnosis and treatment of acute and chronic heart failure

“…Although amiodarone may have reduced mortality in older trials of HF, contemporary studies conducted since the widespread introduction of beta‐blockers suggest that it does not reduce mortality in patients with HFrEF . Dronedarone and class I antiarrhythmic agents should not be used for prevention of arrhythmias in this population.…”

2016 ESC Guidelines for the diagnosis and treatment of acute and chronic heart failure

“…W starszych badaniach amiodaron mógł obniżać śmier-telność w HF [242,243]. Wyniki aktualnie przeprowadzanych badań, w których równolegle stosowano LBA, sugerują, że nie zmniejsza on śmiertelności u pacjentów z HFrEF [227,244,245].…”