Open heart surgery for infants with low body weight (BW) remains still a challenge. Pulmonary artery banding (PAB) is a useful surgical palliation for small neonates and early infants with excessive pulmonary blood flow who are unable to withstand a heart surgery. This study retrospectively reviewed neonates and infants who underwent PAB to assess the surgical results and the validity of our PAB. We selected 38 acyanotic infants and neonates and divided them into 2 groups: low BW (< 2.5 kg, n = 15, group L) and normal or high BW (≥ 2.5 kg, n = 23, group NH). The average BW at the time of PAB was 2.8 ± 1.1 kg (range, 1.2-5.8 kg), and the average age at the time of PAB was 41.8 ± 44.8 days (range, 2-151 days). Using a 3-mm-wide polyester tape, we tightened the main pulmonary artery to obtain the circumference of (19 mm + 1 mm for each kg of BW). There was no early death but one late death in each group. Postoperative BW continuously increased 1 month after PAB in both groups, although BW was significantly lower in group L than in group NH. Intracardiac repair (ICR) was accomplished in 31 patients (13 in group L and 18 in group NH) at average ages of 1.5 years, while the remaining 5 patients are awaiting ICR. In conclusion, PAB using our formula for the infants even weighing < 2.5 kg has low mortality and is effective as a bridge to ICR.Keywords: infant; low birth weight; neonate; palliative surgery; pulmonary artery banding Tohoku J. Exp. Med., 2011, 225 (4), 255-262. © 2011 Tohoku University Medical PressIn neonates and early infants with low body weight (BW), cardiopulmonary bypass surgery increases organ edema and dysfunction, leading to high mortality and morbidity (Oppido et al. 2004). Pulmonary artery banding (PAB) remains a useful surgical palliation for small neonates and early infants with excessive pulmonary blood flow who are unable or difficult to withstand an open heart surgery using cardiopulmonary bypass. PAB can relieve the symptoms of heart failure and respiratory distress and prevent future pulmonary vascular obstructive disease in these infants and intracardiac repair (ICR) can be delayed until they grow. Trusler and Mustard (1972) advocated that the adequate circumference of the PAB using a 4-mm-wide tape in infants without cyanosis was (20 mm + 1 mm for each kg of the infant BW). The Trusler's formula has been used as a standard for PAB in pediatric cardiac surgery field for a long period. However, the average birth BW in the Japan is lower than in the United States and European countries and per se decreased in the recent years. A wider tape for PAB may cause the distal PA stenosis in small neonates and infants. In addition, the average BW in our PAB series was much lower than that reported previously. Therefore, in our institution, we have routinely used a 3-mm-wide tape (1 mm narrower than Trusler's group) and our modified formula (19 mm + 1 mm for each kg of BW), 1 mm shorter circumference than Trusler's formula] had been applied to obtain the appropriate PAB circumference (Fig. 1). Accord...