Mortality Rate in Hospitalized Pediatric Patients with COVID-19 Infection in Iran: A Systematic Review and Meta-Analysis

Golshan-Tafti, Mohammad; Ekraminasab, Sedigheh; Bahrami, Reza; Asadian, Fatemeh

doi:10.18502/wjpn.v5i1.10126

Cited by 2 publications

(2 citation statements)

References 25 publications

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“…Infants infected with SARS-CoV-2 usually had a favorable outcome. 37 Different states of immunocompetence may account for differences in clinical manifestations and prevalence of SARS-CoV-2 infection in infants and adults. The underlying mechanisms of bypassing the severe form of the disease in neonates and pediatrics are unclear.…”

Section: Discussionmentioning

confidence: 99%

Evaluation of Immune Response to COVID-19 in Neonates

Bahrami,

Asadian,

Golshan-Tafti

2023

WJPN

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Background: During the COVID-19 epidemic, many neonates were involved, but they had fewer complications and deaths than adults. Therefore, in this review study, we investigated the immune mechanisms of neonates in response to COVID-19. Methods: We reviewed articles that evaluated the immune system, COVID-19, or SARS-COV2 in neonates. We searched the databases of Google Scholar, PubMed, Scopus, Web of Sciences, SciELO, and CNKI databases published up to December 2022. Results: There are different immune mechanisms in response to COVID-19 in infants, which lead to a different response to COVID-19 compared to adults. The important mechanisms include lower expression of ACE2 receptor, abundant of naive T cells, absence of cytokine storm, abundant of immunosuppressive cells, less inflammatory reactions, breastmilk secretory IgA, transfer of IgG through the placenta, and absence of chronic comorbidities. Also, in comparison with pediatrics multisystem inflammatory syndrome in children (MIS‐C) doesn’t observe in neonates. Conclusion: The exact immune mechanisms in response to COVID-19 in infants have not yet been discovered, but knowing the exact mechanisms can be effective in future treatments, the production of effective vaccines, and other viral treatments, so there is a need for more investigations in this field.

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Section: Discussionmentioning

confidence: 99%

Evaluation of Immune Response to COVID-19 in Neonates

Bahrami,

Asadian,

Golshan-Tafti

2023

WJPN

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“…Children with underlying conditions are at increased risk of severe COVID-19 related mortality than children without underlying illness. 19,20 The high mortality rate may be due to an unknown covid-19 infection. COVID-19 infection in infants has many complications, including cardiac complications.…”

Section: Discussionmentioning

confidence: 99%

The Effect of the Iranian Surfactant (Beraksurf) in the Treatment of Respiratory Distress Syndrome in Premature Neonates

Daya,

Lookzadeh,

Noorishadkam

et al. 2023

WJPN

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Background: Respiratory distress syndrome (RDS) is a type of lung development defect that is commonly seen in preterm births. Deficiency of pulmonary surfactant due to immaturity is the principal cause of RDS in premature infants. This study was conducted with the aim of Iranian surfactant (Beraksurf)’s effect in treating RDS in premature neonates. Methods: In this study, all infants who were premature and had RDS were included in the study. Also, the infants were examined based on primary and secondary outcomes. Primary outcomes include the duration of need for nasal continuous positive airway pressure (NCPAP), number of surfactant administration, and secondary outcomes including bronchopulmonary dysplasia (BPD), pneumothorax, and pulmonary hemorrhage. Results: A total of 162 neonates with a mean gestational age of 31.28 ± 2.58 weeks were evaluated. The 120 people (74.1%) used medicine only on the first day, 19 people on other days, and 23 people on the first and second day. Also, 141 children (87.6%) were discharged from the hospital and unfortunately, 20 children (12.4%) died. The prevalence of pneumothorax, BPD, and pulmonary hemorrhage was 1.8%, 1.2%, and 1.2% respectively. Also, 69.7% needed less than five days of mechanical ventilation and 30.2% needed more than 5 days of mechanical ventilation. Conclusion: Considering getting better treatment results from taking Beraksurf, as well as fewer side effects and the fact that this drug is Iranian, and due to its easier access and cheaper price, we can pay more attention to the prescription of this drug.

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Mortality Rate in Hospitalized Pediatric Patients with COVID-19 Infection in Iran: A Systematic Review and Meta-Analysis

Cited by 2 publications

References 25 publications

Evaluation of Immune Response to COVID-19 in Neonates

Evaluation of Immune Response to COVID-19 in Neonates

The Effect of the Iranian Surfactant (Beraksurf) in the Treatment of Respiratory Distress Syndrome in Premature Neonates

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