Mortality rate of ICU patients with the Middle East Respiratory Syndrome - Coronavirus infection at King Fahad Hospital, Jeddah, Saudi Arabia

Garout, Mohammed; Jokhdar, Hani; AlJahdali, Imad A; Zein, Ahmed Ragab; Goweda, Reda; Hassan-Hussein, Abdurahman

doi:10.21101/cejph.a4764

Cited by 17 publications

(19 citation statements)

References 9 publications

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“…Deaths and serious consequences in older patients have also been reported for other human coronaviruses, such as HCoV-OC43 [17], SARS-CoV [3], and MERS-CoV [18]. Older age has been reported as an important independent risk factor for mortality in SARS [19] and MERS [20].…”

Section: Discussionmentioning

confidence: 91%

Comparison of clinical characteristics and outcomes of patients with coronavirus disease 2019 at different ages

Zhao

Wang

Zhang

et al. 2020

Aging

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Background: Information about the clinical characteristics and mortality of patients with coronavirus disease 2019 at different ages is limited. Results: The older group had more patients with dyspnea and fewer patients with fever and muscle pain. Older patients had more underlying diseases, secondary infection, myocardial injury, renal dysfunction, coagulation dysfunction, and immune dysfunction on admission. More older patients received immunoglobulin therapy and mechanical ventilation. The proportions of patients with multiple organ injuries, critically ill patients and death increased significantly with age. The older groups had higher cumulative death risk than the younger group. Hypertension, cerebrovascular disease, comorbidities, acute cardiac injury, shock and complications are independent predictors of death. Conclusions: The symptoms of the elderly patients were more atypical, with more comorbidities, secondary infection, organ injuries, immune dysfunction and a higher risk of critical illness. Older age was an important risk factor for mortality. Methods: 1000 patients diagnosed with coronavirus disease 2019 from January 1, 2020 to February 14, 2020 were enrolled. According to age, patients were divided into group 1 (<60 years old), group 2 (60-74 years old) and group 3 (≥75 years old). The clinical symptoms, first laboratory results, CT findings, organ injuries, disease severity and mortality were analyzed. www.aging-us.com 10071 AGING acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection is still increasing. The numbers of infected patients and deaths both exceeded the respective figures associated with the outbreaks of severe acute respiratory syndrome (SARS) in 2003 [3] and Middle East respiratory syndrome (MERS) in 2015 [4]. Compared to the mortality of SARS (10%) and MERS (35%), COVID-19 has a lower fatality rate of 2.3% [5-7]. However, the rapidly increasing number of cases and increasing evidence of human-to-human transmission suggest that SARS-CoV-2 is more contagious than SARS-CoV and MERS-CoV [8, 9].

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Section: Discussionmentioning

confidence: 91%

Comparison of clinical characteristics and outcomes of patients with coronavirus disease 2019 at different ages

Zhao

Wang

Zhang

et al. 2020

Aging

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“…An important consideration in our study was the outbreak of the Middle East Respiratory Syndrome Coronavirus (MERS-CoV) infection that occurred during the study period. Thus, MERS-CoV infection requiring admission to ICUs was associated with high mortality, as 72% such patients died in ICUs 12…”

Section: Discussionmentioning

confidence: 99%

“…In Saudi Arabia, many studies have examined the mortality outcome of patients admitted to ICUs; however, some of those studies have evaluated the outcome of patients receiving mechanical ventilation for specific indications, such as with severe respiratory conditions,11,12 or have focused on a specific population such as that with a hematological malignancy 11-14. However, the survival of patients admitted to an ICU and received mechanical ventilation with various indications and among heterogenous population has not been reported in Saudi Arabia.…”

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confidence: 99%

Survival of mechanically ventilated patients admitted to intensive care units

Ismaeil

Almutairi²,

Alshaikh³

et al. 2019

SMJ

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Objectives: To estimate the survival of adult and pediatric patients receiving mechanical ventilation and determine the associated risk factors Methods: A retrospective cohort study was carried out in the intensive care unit (ICU) at King Abdulaziz Medical City (KAMC) and King Abdullah Children’s Specialist Hospital (KACSH), Riyadh, Saudi Arabia. The analysis includes data from medical records of all patients admitted to ICUs who received mechanical ventilation between 2016-2018. For each patient, potential risk factors were collected. The main outcome of this study was the mortality during the stay in ICU after receiving mechanical ventilation Results: A total of 262 adults and 175 pediatric patients were admitted to ICUs and received mechanical ventilation during the study period. For adult patients, the overall mortality was 37%, with a median survival time of 11 days (interquartile range [IQR] 6-20 days). The main risk factors independently associated with the increased mortality rate were being aged 51-60 (odds ratio [OR] 2.6, 95% confidence interval [CI] 6.7-1.0) and factors related to ICU admission. For the pediatric population, the mortality rate was 17%, with a median survival time of 16 days (IQR 7-37 days). Prematurity with respiratory problems was the main recorded cause of initiation of mechanical ventilation (50% of patients). Neonates who had mechanical ventilation within one month of their birth and were born extremely preterm had a high mortality rate after the initiation of mechanical ventilation. Conclusion: Both patient age and the causes of the initiation of mechanical ventilation were influencing the survival of patients who required mechanical ventilation.

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“…5 The MERS-CoV caused severe pneumonia with an intensive care unit (ICU) admission rate of 40-50% and an inhospital ICU death rate of 75%. 6,7 In December 2019, the city of Wuhan in Hubei Provence, China, reported a small outbreak of a novel coronavirus, COVID-19. The fatality rate is highest in adults ≥85 years old (10-27%), followed by 65-84 years (3-11%) with 50% of ICU admission among persons ≥65 years.…”

Section: Pathogensmentioning

confidence: 99%

A Comprehensive Review of Manifestations of Novel Coronaviruses in the Context of Deadly COVID-19 Global Pandemic

Gulati¹,

Pomeranz²,

Qamar³

et al. 2020

The American Journal of the Medical Sciences

116

129

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Since December 2019, the global pandemic caused by the highly infectious novel coronavirus 2019-nCoV (COVID-19) has been rapidly spreading. As of April 2020, the outbreak has spread to over 210 countries, with over 2,400,000 confirmed cases and over 170,000 deaths. 1 COVID-19 causes a severe pneumonia characterized by fever, cough and shortness of breath. Similar coronavirus outbreaks have occurred in the past causing severe pneumonia like COVID-19, most recently, severe acute respiratory syndrome coronavirus (SARS-CoV) and middle east respiratory syndrome coronavirus (MERS-CoV). However, over time, SARS-CoV and MERS-CoV were shown to cause extrapulmonary signs and symptoms including hepatitis, acute renal failure, encephalitis, myositis and gastroenteritis. Similarly, sporadic reports of COVID-19 related extrapulmonary manifestations emerge. Unfortunately, there is no comprehensive summary of the multiorgan manifestations of COVID-19, making it difficult for clinicians to quickly educate themselves about this highly contagious and deadly pathogen. What is more, is that SARS-CoV and MERS-CoV are the closest humanity has come to combating something similar to COVID-19, however, there exists no comparison between the manifestations of any of these novel coronaviruses. In this review, we summarize the current knowledge of the manifestations of the novel coronaviruses SARS-CoV, MERS-CoV and COVID-19, with a particular focus on the latter, and highlight their differences and similarities.

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Mortality rate of ICU patients with the Middle East Respiratory Syndrome - Coronavirus infection at King Fahad Hospital, Jeddah, Saudi Arabia

Abstract: MERS-CoV ICU mortality remains markedly high due to a combination of factors; the disease process of MERS-CoV leads to multiple organ failure, particularly respiratory and renal failure.

Cited by 17 publications

References 9 publications

Comparison of clinical characteristics and outcomes of patients with coronavirus disease 2019 at different ages

Comparison of clinical characteristics and outcomes of patients with coronavirus disease 2019 at different ages

Survival of mechanically ventilated patients admitted to intensive care units

A Comprehensive Review of Manifestations of Novel Coronaviruses in the Context of Deadly COVID-19 Global Pandemic

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