Mortality Resulting From Congenital Heart Disease Among Children and Adults in the United States, 1999 to 2006

Gilboa, Suzanne M.; Salemi, Jason L.; Nembhard, Wendy N.; Fixler, David E; Correa, Adolfo

doi:10.1161/circulationaha.110.947002

Cited by 524 publications

(364 citation statements)

References 44 publications

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“…These findings confirm the results of Jacobs et al who, in a Hong Kong population, found that white children had more left ventricular obstructive lesions, whereas Chinese children had more right ventricular outflow tract lesions [6]. Race and ethnic differences in mortality in CHD have been demonstrated by Gilboa et al [7]. By means of death certificates filed in the United Fig.…”

Section: Race and Ethnicitysupporting

confidence: 89%

Epidemiology of adult congenital heart disease: demographic variations worldwide

Mulder

2012

Neth Heart J

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The population of adults with a congenital heart defect (CHD) is increasing, due to improved survival after cardiac surgery. To accommodate the specialised care for these patients, a profound interest in the epidemiology of CHD is required. The exact size of the current population of adults with CHD is unknown, but the best available evidence suggests that currently overall prevalence of CHD in the adult population is about 3000 per million. Regional differences in CHD prevalence have been described, due to both variations in incidence and in mortality. Knowledge of demographic variations of CHD may lead to new aetiological insights and may be useful for preventive therapies. Socioeconomic status, education, urbanisation, climatological factors, ethnicity and patient-related factors, such as comorbidity, lifestyle and healthcare-seeking behaviour, may play a role in CHD incidence and mortality. The higher risk of several major cardiac outcomes in males with CHD might well explain at least partly the increased mortality rate in men. Regional differences in quality of life among CHD patients have been reported and although methodological differences may play a role, sociocultural differences warrant further attention. Socioeconomic outcomes in CHD patients, such as lower education, more unemployment and less relationships, might have a different impact on quality of life in different cultures. To gain more insight into demographic differences around the world large international multicentre studies on the epidemiology of CHD are needed.

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Section: Race and Ethnicitysupporting

confidence: 89%

Epidemiology of adult congenital heart disease: demographic variations worldwide

Mulder

2012

Neth Heart J

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“…[1][2][3][4] Although the outcome has improved over the past decades, morbidity and mortality remain high, especially in infants with critical congenital heart disease (CCHD) in which circulation is dependent on ductal or interatrial shunting. [5][6][7] A large Swedish populationbased study reported that the risk of being discharged with undiagnosed duct-dependent CCHD was 28%. 8 Recently, Peterson et al 9 reported in a US population-based study that 29.5% of 3746 infants with CCHD were diagnosed late, after 3 days of birth.…”

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confidence: 99%

Age at Referral and Mortality From Critical Congenital Heart Disease

Fixler

Nembhard

et al. 2014

Pediatrics

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BACKGROUND AND OBJECTIVE: Newborn pulse oximetry screening is recommended to promote early referral of neonates with critical congenital heart disease (CCHD) and reduce mortality; however, the impact of late referral on mortality is not well defined. The purpose of this population-based study was to describe the association between timing of referral to a cardiac center and mortality in 2360 liveborn neonates with CCHD. METHODS: Neonates with CCHD born before pulse oximetry screening (1996–2007) were selected from the Texas Birth Defects Registry and linked to state birth and death records. Age at referral was ascertained from date of first cardiac procedure at a cardiac center. Logistic and Cox proportional hazards regression models were used to estimate factors associated with late referral and mortality; the Kaplan-Meier method was used to estimate 3-month survival. RESULTS: Median age at referral was 1 day (25th–75th percentile: 0–6 days). Overall, 27.5% (649 of 2360) were referred after age 4 days and 7.5% (178 of 2360) had no record of referral. Neonatal mortality was 18.1% (277 of 1533) for those referred at 0 to 4 days of age, 9.0% (34 of 379) for those referred at 5 to 27 days of age, and 38.8% (69 of 178) for those with no referral. No improvement in age at referral was found across the 2 eras within 1996–2007. CONCLUSIONS: A significant proportion of neonates with CCHD experienced late or no referral to cardiac specialty centers, accounting for a significant number of the deaths. Future population-based studies are needed to determine the benefit of pulse oximetry screening on mortality and morbidity.

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“…Congenital heart disease (CHD) and early acquired heart disease (EAHD) are of special importance in adolescents as they may impact their subsequent health as they age [2], [3]. Many studies which investigated the prevalence of CHD in fetal and newborn populations found fewer subjects than in population studies of older children and adolescents [4], [5].…”

Section: Introductionmentioning

confidence: 99%

Cardiac anomalies and associated comorbidities in a large adolescent population

Fink

Machluf

Farkash

et al. 2017

International Journal of Adolescent Medicine and Health

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Abstract:Objective: To determine the prevalence, secular trends and associations of heart disease in a large unscreened, otherwise basically healthy, adolescent population. Subjects and methods: Cross-sectional study of the cardiac status of 113,694 adolescents from the northern district of Israel, who completed the profiling process between the ages of 16 and 19, including all essential measures over a 22-year period. Results of imaging were categorized as either isolated valvar or structural abnormalities, and their clinically significant subgroups defined prospectively. The findings were correlated with the socio-demographic and anthropometric data and non-cardiac health conditions. Results: Of those sent for echocardiography, 1257 (0.93% of the total population) had isolated valvar disease and 216 (0.19%) had structural abnormalities, with 20% of both groups considered significant. Females had lower prevalence of heart disease. There was peak prevalence in the second 5-year period. Tall subjects or a past history of rheumatic fever had more valvar abnormalities. Thin subjects or those with skeletal anomalies had more structural abnormalities. Significant valvar and structural anomalies were more common in subjects with learning disorders, endocrine disorders and diabetes mellitus. Fewer valvar abnormalities were diagnosed in obese subjects. Heart disease was more common in those with non-solid tumors. Conclusion: Appreciable numbers of potentially healthy adolescents were found to have heart disease. There appeared to be an association with body size, skeletal abnormalities and relatively common medical disorders, the cause of which remains to be determined in prospective studies that could change the way common adolescent disease should be followed.

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Mortality Resulting From Congenital Heart Disease Among Children and Adults in the United States, 1999 to 2006

Cited by 524 publications

References 44 publications

Epidemiology of adult congenital heart disease: demographic variations worldwide

Epidemiology of adult congenital heart disease: demographic variations worldwide

Age at Referral and Mortality From Critical Congenital Heart Disease

Cardiac anomalies and associated comorbidities in a large adolescent population

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