Mortality Risk in IgA Nephropathy

Abstract

as an excretory organ. Whether the nephrocytes can also secrete back into the hemolymph (for example, after metabolization) remains to be investigated. Other obvious differences to podocytes are that nephrocytes are unipolar single cells that form intracellular and not intercellular slit diaphragms. Moreover, filtration is most likely facilitated by oscillating fluctuations caused by the contracting heart (for pericardial nephrocytes) and the peristaltic proventriculus (for garland nephrocytes) and not facilitated by a high-BP system, like in the glomerulus. The demand is increasing for rapid functional validation of genes variants derived from the sequencing outputs for renal genetic diseases. Drosophila nephrocytes have proven to be an easy to use alternative for such efforts. As with any other existing model system, nephrocytes do not provide a complete solution. Yet, the effortless ex vivo analysis of nephrocytes and the structural and functional similarity to podocytes and proximal tubular cells as well as the plethora of powerful genetic tools from the Drosophila community can offer an intermediate platform that bridges the experimental gaps to other experimental models. ACKNOWLEDGMENTS Work in the Simons lab is supported by the ATIP-Avenir program as well as funding by the Agence Nationale de la Recherche (ANR) under the "Investissements d'avenir" program (ANR-10-IAHU-01) and the NEPHROFLY (ANR-14-ACHN-0013) grant.

Efficacy and Safety of Renin-Angiotensin Aldosterone System Inhibitor in Patients with IgA Nephropathy: A Meta-Analysis of Randomized Controlled Trials

“…Proteinuria is not only one of the manifestations of renal lesions, but also an independent factor of renal damage, which is positively correlated with the severity of renal disease (25). Therefore, proteinuria is an important factor in determining the prognosis of IgAN patients.…”

T lymphocytes in IgA nephropathy (Review)

“…It is widely known that IgAN is the most common immune complex associated with the cause of glomerulonephritis in the world (48,49). There is emerging evidence which shows that the imbalance of Th1/Th2 pro-inflammatory cytokines plays an important role in the development and progression of IgAN (42,43).…”

Immunosuppressive therapy versus supportive care in IgA nephropathy patients with stage 3 and 4 chronic kidney disease

“…Immunoglobulin A nephropathy (IgAN) is the most prevalent cause of primary glomerular disease in the world and one of the most frequent reasons for younger adults to require kidney replacement therapy. [1,2]…”

“…Observational studies have suggested that corticotherapy might be of benefit when the eGFR drops under 50 mL/min/1.73 m 2 , especially in the presence of high level of proteinuria, but the threshold at which the treatment efficiency is lost is not well defined. [3] However, subanalyses of the most recent randomized controlled trials failed to show any benefit of immunosuppressive therapy in patients with eGFR 30 to 60 mL/ min/1.73 m 2 in the STOP-IgAN and 20 to 50 mL/min/1.73 m 2 in the Therapeutic Evaluation of Steroids in IgA Nephropathy…”