Mortality trends and geographic distribution of kidney cancer in Peru: a secondary analysis

Torres-Román, J. Smith; Cruz-Ku, Gabriel De la; Juárez-Leon, Valeria; Calderón-Solano, Delahnie; Bazalar-Palacios, Janina; Vecchia, Carlo La; Pinheiro, Paulo Sérgio

doi:10.1186/s12894-023-01208-7

Cited by 2 publications

(1 citation statement)

References 21 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…0n the contrary, there are very little evidence of PAF for cases and deaths for cancer in Latin-American countries and do not exits PAF’s studies in Peru that consider all the risk factors and allow the estimation of the total number of cancer cases and deaths attributable to said risk factors. However, do exits PAF studies of some risk factors and derivate diseases (as can be observe on the tobacco consumption [ 17 , 18 ] mortality tendencies for different cancer’s type, as gastric [ 19 ], kidney [ 20 ], cervical cancer [ 21 ], mesothelioma [ 22 ]). The sole Latin-American’s country that have one study of PAF for cancer is Brazil [ 16 ]; on the other hand, Chile has one PAF study that considers only lifestyle risk factors, not including oncogenic infections [ 23 ].…”

Section: Introductionmentioning

confidence: 99%

Proportion of cancer cases and deaths attributable to potentially modifiable risk factors in Peru

De La Cruz-Vargas,

Ramos,

Chanduví

et al. 2024

BMC Cancer

View full text Add to dashboard Cite

Background Limited evidence exists on the population attributable fraction (PAF) of cancer cases and deaths in Latin America. In Peru several studies have been published regarding the PAF of various risk factors and their associated diseases. The objective of this study was to estimate the fraction of cancer cases and deaths attributable to potentially modifiable risk factors in Peru in 2018, before the COVID-19 pandemic in the population of 15 years old and older. Methods An ecological study was conducted using the prevalence of exposure of the Peruvian population to modifiable risk factors for cancer, the relative risk associated with each factor, and the number of cancer cases and deaths in 2018 as inputs. We used the Parkin formula with a Montecarlo statistical simulation model to calculate the PAF and confidence intervals. The number of new cancer cases and deaths attributed to each risk factor was determined by multiplying the number of cases and deaths in each gender by the PAF of each risk factor. Findings In Peru, 38.5% of new cases (34.5% in men and 42% in women) and 43.4% of cancer-related deaths (43.4% in men and 43.4% in women) were attributable to modifiable risk factors. The number of cancers attributable was 25,308 (10,439 in men and 14,869 in women) and the number of deaths attributable to cancer was 14,839 (6,953 in men and 7,886 in women). The predominant modifiable risk factors contributing to the highest number of cases and deaths were HPV infection (4,563 cases, 2,409 deaths), current tobacco use (3,348 cases, 2,180 deaths), and helicobacter pylori infection (2,677 cases, 1,873 deaths). Among the risk factors, oncogenic infections constituted the group with the highest PAF (16.6% for cases, 19.2% for deaths) followed by other unhealthy lifestyle factors (14.2% for cases, 16.7% for deaths), tobacco (7.2% for cases, 7.2% for deaths) and ultraviolet radiation (0.5% for cases, 0.3% for deaths). Conclusions Prior to the COVID-19 pandemic, 38.5% of cancer cases and 43.4% of cancer-related deaths in Peru were linked to modifiable risk factors in the population of 15 years old and older. Most preventable cancer cases and deaths were related to oncogenic infections, primarily caused by HPV and helicobacter pylori, followed by tobacco and obesity.

show abstract

Section: Introductionmentioning

confidence: 99%

Proportion of cancer cases and deaths attributable to potentially modifiable risk factors in Peru

De La Cruz-Vargas,

Ramos,

Chanduví

et al. 2024

BMC Cancer

View full text Add to dashboard Cite

show abstract

Microbial and potentially toxic elements risk assessment in high Andean river water based on Monte Carlo simulation, Peru

Custodio,

Peñaloza,

Ochoa

et al. 2023

Sci Rep

View full text Add to dashboard Cite

The study evaluated microbial and Potentially Toxic Elements—PTEs risks in high Andean river water in Peru using Monte Carlo simulation. A total of 144 water samples were collected from four rivers and evaluated for physicochemical parameters, PTEs and bacterial pathogens. The microbial risk analysis for exposure to pathogens present in the water was based on the probability of occurrence of diseases associated with Escherichia coli, Pseudomonas aeruginosa and enterococci. PTEs risk analysis was performed using a Monte Carlo simulation approach. The results showed that the highest microbial risk due to exposure to water contaminated by E. coli, P. aeruginosa and enterococci was recorded in the Miraflores and Chia rivers. Meanwhile, the analysis of carcinogenic and non-carcinogenic risk by PTEs in adults and children revealed that the Chia river presents a high risk of contamination by PTEs, especially the carcinogenic risk for children. The Monte Carlo simulation indicated a 56.16% and 94.85% probability of exceeding the limit value of 0.0001 for carcinogenic risk in adults and children, respectively. It can be concluded that children consuming the waters of the Chia river are potentially at risk of As toxicity.

show abstract

Mortality trends and geographic distribution of kidney cancer in Peru: a secondary analysis

Cited by 2 publications

References 21 publications

Proportion of cancer cases and deaths attributable to potentially modifiable risk factors in Peru

Proportion of cancer cases and deaths attributable to potentially modifiable risk factors in Peru

Microbial and potentially toxic elements risk assessment in high Andean river water based on Monte Carlo simulation, Peru

Contact Info

Product

Resources

About