Mortality trends in women and men with COPD in Ontario, Canada, 1996–2012

Gershon, Andrea S.; Hwee, Jeremiah; Victor, J. Charles; Wilton, Andrew S.; Wu, Robert; Day, Anna; To, Teresa

doi:10.1136/thoraxjnl-2014-205956

Cited by 33 publications

(26 citation statements)

References 21 publications

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“…A difference between sexes in the prevalence of COPD has been reported previously [20e22]. A sharp decline in male mortality from COPD compared with that in women and a narrowing in the sex gap have been described in Canada and Europe [20,23]. The reason for this may be that women with COPD appear to have earlier onset and a more rapid decline in lung function, despite similar cigarette exposure [21,22,24].…”

Section: Discussionmentioning

confidence: 68%

Changes in the prevalence of COPD in Korea between 2001 and 2011 in the KNHANES data

Hong

Jung

Lee

et al. 2017

Respiratory Medicine

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Section: Discussionmentioning

confidence: 68%

Changes in the prevalence of COPD in Korea between 2001 and 2011 in the KNHANES data

Hong

Jung

Lee

et al. 2017

Respiratory Medicine

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“…This scenario has changed in recent years as there has been a steady increase in COPD prevalence and mortality rates in women. In the US, for example, the number of COPD-associated deaths in women has equaled or surpassed that in men (1), while in Canada, a longitudinal population study revealed a greater decrease in COPD-related mortality trends in men versus women (2). The increased prevalence of COPD among women is likely attributable to several factors including the increased rates of cigarette smoking observed in women during recent years, exposure to indoor air pollution (biomass) as well as increased occupational exposures as women take on previously male-dominated occupational roles related to risk exposure (3).…”

Section: Introductionmentioning

confidence: 99%

Response to Indacaterol/Glycopyrronium (IND/GLY) by Sex in Patients with COPD: A Pooled Analysis from the IGNITE Program

Tsiligianni

Mezzi

Fucile

et al. 2017

COPD: Journal of Chronic Obstructive Pulmonary Disease

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In this pooled analysis, we compared the effect of indacaterol/glycopyrronium (IND/GLY) by sex versus other commonly used chronic obstructive pulmonary disease (COPD) treatments and placebo. Male and female patients with moderate-to-very-severe COPD who had participated in six randomized controlled trials were included in the analysis. Baseline demographics and disease characteristics were analyzed by sex, and any differences noted. The effects of IND/GLY versus salmeterol/fluticasone (SFC), glycopyrronium, tiotropium and placebo, on lung function and the patient-reported outcomes (health status, dyspnea, rescue medication use and symptoms) were assessed by sex after 26 weeks treatment. The analysis population comprised 4719 men and 1389 women. Most baseline parameters differed significantly between men and women. Nonetheless, despite these differences in baseline characteristics, IND/GLY significantly improved lung function versus placebo (p < 0.0001) and all active comparators (p < 0.01) in men and women. Overall, IND/GLY showed better improvement in dyspnea and health status compared with all other treatments in both sex. Greater reduction of rescue medication use was observed with IND/GLY versus placebo and other treatments (all p < 0.01 expect IND/GLY versus SFC). Although some variability was observed, improvements in health status, dyspnea, rescue medication use and symptoms were generally larger in women than in men. Irrespective of sex, IND/GLY provided superior efficacy to monotherapy or SFC in both men and women. Small differences in efficacy response by sex were observed, which should be evaluated further in prospective clinical studies. Nevertheless, the benefits observed with IND/GLY confirm dual bronchodilator as the preferred therapy in patients with moderate-to-very-severe COPD regardless of sex.

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“…26 This case definition was found to have a sensitivity and specificity of 85.0% and 78.4%, respectively, for identifying COPD with Ontario's health administrative records and has been used extensively to study outcomes among people with COPD. 27,28…”

Section: Discussionmentioning

confidence: 99%

Incidence of chronic obstructive pulmonary disease in people with HIV in Ontario, 1996–2015: a retrospective population-based cohort study

Antoniou

Yao

Raboud

et al. 2020

cmajo

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Mortality trends in women and men with COPD in Ontario, Canada, 1996–2012

Cited by 33 publications

References 21 publications

Changes in the prevalence of COPD in Korea between 2001 and 2011 in the KNHANES data

Changes in the prevalence of COPD in Korea between 2001 and 2011 in the KNHANES data

Response to Indacaterol/Glycopyrronium (IND/GLY) by Sex in Patients with COPD: A Pooled Analysis from the IGNITE Program

Incidence of chronic obstructive pulmonary disease in people with HIV in Ontario, 1996–2015: a retrospective population-based cohort study

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