Mortality Trends Related to Bladder Cancer in Spain, 1999–2018

Abstract

Bladder cancer (BC) is an important cause of premature mortality (PM, <75 years). Spain has one of the highest BC mortality rates in Europe. The objective of this study was to analyse BC mortality trends between 1999 and 2018 in Spain. The study was based on data from the National Institute of Statistics (Instituto Nacional de Estadística—INE). Age-adjusted mortality rates (AAMRs) were calculated by sex and age group. A trend analysis was performed using Joinpoint regression models and years of potential life lost (YPLL). Mortality in men resulting from BC decreased in all age groups studied. This was not observed in women, for whom mortality only decreased in the ≥75 age group. Deaths due to BC occurred prematurely in 38.6% of men and in 23.8% of women, which indicated a greater impact on YPLL in men compared to women. Over the last 20 years, there has been a significant decrease in BC mortality rate, except in women under 75 years of age. Despite this temporal trend of decreasing mortality, BC continues to have a significant impact on YPLL, mainly in men. Given this context, it is important to direct more resources towards prevention and early diagnosis strategies to correct this situation.

A Novel Decision Tree Model for Predicting the Cancer-Specific Survival of Patients with Bladder Cancer Treated with Radical Cystectomy

“…Urothelial bladder cancer (UBC) is the second most common urological malignancy, with a 2-7.1 (per 100,000) annual age-standardized mortality rate in the United States and 10.1 in Europe [1][2][3]. Despite mortality rates decreasing, there are expected to be almost 16,700 deaths due to bladder cancer in the United States at 2023 [4,5]. At 5 years, the cancer-specific survival for patients with muscle invasive ranges from 23.5% to 65%, depending on the study [6].…”