MoS2-Catalyzed Aerobic Synthesis of Tetraethylthiuram Disulfide in Batch and Continuous Flow

Abstract

Tetraethylthiuram disulfide (TETD) is one of the most important thiuram-class rubber vulcanization accelerators and a “star molecule” in other areas. The development of a mild, efficient, low-cost, safe and sustainable approach to produce TETD is extremely desirable. Here, we developed a much-improved route to synthesize TETD using MoS2 as the catalyst and ethanol as the solvent. A packed-bed microflow strategy was implemented to accelerate the catalytic process. TETD was obtained with an excellent yield and purity within a short residence time. Besides, this continuous process did not generate any waste salts, rendering it a sustainable method for producing thiuram-type compounds.

DoE‐Assisted Development of a 2H−MoS2‐Catalyzed Approach for the Production of Indole Derivatives

“…[8] In the vast field of heterogeneous catalysis, (1T-, 2H-, or 1T/ 2HÀ )MoS 2 , either as pure solid or as part of a nanocomposite, has been proven to be an effective catalytic material in several organic reactions, including nitroarene reduction, crotonaldehyde hydrogenation and disulfide synthesis from carbon disulfide. [10][11][12] Moreover, MoS 2 -based quantum dots have been used to perform the light-driven functionalization of ketones and the cross-dehydrogenative coupling reaction between tertiary amines and suitable nucleophiles. [13,14] In particular, the Lewis acid catalytic sites of 2HÀ MoS 2 are located at terminal Mo atoms as well as at sulfur vacancies.…”