Mosaic Expression of Brush-Border Enzymes in Infants with Chronic Diarrhea and Malnutrition

Nichols, Buford L.; Carrazza, Francisco Roque; Nichols, Veda N.; Putman, Margaret; Johnston, Pamela; Rodrigues, Maraci; Quaroni, Andrea; Shiner, Margot

doi:10.1097/00005176-199205000-00002

Cited by 25 publications

(19 citation statements)

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“…The studies of Nichols et al . who did repeated intestinal biopsies in malnourished children were able to separate the effects of malnutrition from villous atrophy on the disaccharidases by the use of messenger RNA assays of lactase, maltase, sucrase and SGLT 1 44–48 . These results confirm that lactose intolerance is a concern in malnourished children because of the combined independent effects of malnutrition and villous atrophy on lactase levels.…”

Section: Lactose Intolerancementioning

confidence: 53%

Critical appraisal of the management of severe malnutrition: 3. Complications

Brewster

2006

J Paediatrics Child Health

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The high case-fatality of severe malnutrition is due to infections, dehydration, electrolyte disturbances and heart failure. We focus on the evidence about managing these complications of severe malnutrition. Signs of circulatory collapse in severely malnourished children should be treated with intravenous or bone marrow infusion of Ringer's lactate with additional dextrose and potassium at a rate 20-40 mL/kg fast with close monitoring of vital signs. Recommendations for slow or restricted fluids in the face of shock are unsafe, and hypotonic or maintenance solutions must be avoided to prevent hyponatraemia. However, the evidence that severely malnourished children do not tolerate excessive fluid administration is good, so caution must be exercised with regards to fluids in the initial phase of treatment. There is also good evidence that wide spectrum antibiotics need to be given empirically for severe malnutrition to prevent the otherwise unavoidable early mortality. There is a need for improved protocols for tuberculosis diagnosis, HIV management and treatment of infants under 6 months with severe malnutrition. The contribution of environmental enteropathy to poor growth and nutrition during the weaning period means that there should be more priority on improving environmental health, particularly better hygiene and less overcrowding. A T-cell mediated enteropathy contributes to growth failure and malnutrition, and it is related to environmental contamination of enteric organisms in the weaning period rather than allergic responses.

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Section: Lactose Intolerancementioning

confidence: 53%

Critical appraisal of the management of severe malnutrition: 3. Complications

Brewster

2006

J Paediatrics Child Health

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“…For example, loss of MV in chronic and protracted diarrhoea was accompanied by a substantial decrease in dissacharidase activities. [33][34][35][36][37] Interestingly, epidemiological studies indicated that Afa/Dr DAEC strain C1845 was implicated in protracted diarrhoea in infants. [15][16][17][18] To infect host cells, microbial pathogens use very sophisticated mechanisms of pathogenicity.…”

Section: Discussionmentioning

confidence: 99%

Lactobacillus acidophilus (strain LB) from the resident adult human gastrointestinal microflora exerts activity against brush border damage promoted by a diarrhoeagenic Escherichia coli in human enterocyte-like cells

Moal

Amsellem²,

Servin³

et al. 2002

Gut

132

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“…Sin embargo, la informacion sobre los cambios que ocurren en casos no congenitos es muy escasa ? " 9 . El prop6sito de esta experiencia fue evaluar la informacidn obtenida con el metodo de identificacion de enzimas del ribete estriado mediante amicuerpos inonoclonalcs, en comparacion con otros mas corrientes.…”

Section: Valuation Of Microvilli Enzimes By Monoclonal Antibodies In unclassified

“…Los resultados de este estudio difieren con otros obtenidos en ninos desnutridos. con diarrea cronica, en los que todos los pacientes ten fan expresion de sacarasa-isomaltasa en vellosidades y criplas, independientemente del grado de dano morfologico que presentaran 9 . Los anticuerpos monoclonales para enzimas del ribcte estriado aportan informacion novedosa acerca del comportamiento de e"stas.…”

Section: Comentariounclassified

Anticuerpos monoclonales en la evaluación de enzimas del ribete estriado yeyunal de lactantes con diarrea persistente

Q¹,

M²,

G³

et al. 1996

Rev. chil. pediatr.

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valuation of microvilli enzimes by monoclonal antibodies in infants with longstanding diarrheaExpress on o' srnal in-estirie mic'ovilli enzimes lac'ase, sucrase-isomaltase, maltose and aninooeptidase by monoclonal antibodies was studied i-1 biopsies of yeyunai mucosa from eight mfa n ts (age 2 to 1 2 months) and two toddlers (aged 16 and 33 months! xvth persisted diarnea. Results were comparec with clinical findings, nucosal morphocgy (light microscopy], d: saccharidase activities |Dah.qvisti, and Mstochemical expression of lactase. Aminopeptidase was expressed oy monoc'onal anybodies in all pct'erts, both in crypts and villi. Lactase exp-ession by monoclonal antibodies in villi was in agreement with resits of h'stochenical and Dahlqvist methods while ir only two cnidrens "he corresponding enzimes became expressed by monoclonal antibodies in crypts. Sucrase-isomaltase expression by monoclonal antibodies in villi fended to oe more frequent in patient where nucosal morphology was best preserved, excep* for one case who had a primary enzime def ; ciency, even though they were detecteo in the crypts of all but two cases that also showed nc expression in their v Li. Evaluation of microvilli enzimes by monoclonal antibody expression in pa'ients with seconder/ damage to the snail intestine may be useful, because it nay er.hcnce the u r derstanding of impairment a-.d repair mec r -anisms and help to es'imate orogrosis of patients with b r gstanding diarrhea.

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Mosaic Expression of Brush-Border Enzymes in Infants with Chronic Diarrhea and Malnutrition

Cited by 25 publications

References 0 publications

Critical appraisal of the management of severe malnutrition: 3. Complications

Critical appraisal of the management of severe malnutrition: 3. Complications

Lactobacillus acidophilus (strain LB) from the resident adult human gastrointestinal microflora exerts activity against brush border damage promoted by a diarrhoeagenic Escherichia coli in human enterocyte-like cells

Anticuerpos monoclonales en la evaluación de enzimas del ribete estriado yeyunal de lactantes con diarrea persistente

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