Mosquito Peptide Hormones

Strand, Michael R.; Brown, Mark R.; Vogel, Kevin J.

doi:10.1016/bs.aiip.2016.05.003

Cited by 30 publications

(20 citation statements)

References 205 publications

(381 reference statements)

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“…Future work regarding potential effects of ABA on A. stephensi larval feeding behavior could focus on sulfakinin and neuropeptide F, both of which modulate feeding behavior in D. melanogaster larvae (Söderberg et al, 2012;Fadda et al, 2019). Both neuropeptides are also known to be conserved in A. gambiae (Strand et al, 2016) and are represented as orthologs in A. stephensi 1 .…”

Section: Discussionmentioning

confidence: 99%

Comprehensive and Durable Modulation of Growth, Development, Lifespan and Fecundity in Anopheles stephensi Following Larval Treatment With the Stress Signaling Molecule and Novel Antimalarial Abscisic Acid

et al. 2020

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The larval environment of holometabolous insects determines many adult life history traits including, but not limited to, rate and success of development and adult lifespan and fecundity. The ancient stress signaling hormone abscisic acid (ABA), released by plants inundated with water and by leaf and root fragments in water, is likely ubiquitous in the mosquito larval environment and is well known for its wide ranging effects on invertebrate biology. Accordingly, ABA is a relevant stimulus and signal for mosquito development. In our studies, the addition of ABA at biologically relevant levels to larval rearing containers accelerated the time to pupation and increased death of A. stephensi pupae. We could not attribute these effects, however, to ABA-dependent changes in JH biosynthesis-associated gene expression, 20E titers or transcript patterns of insulin-like peptide genes. Adult females derived from ABA-treated larvae had reduced total protein content and significantly reduced post blood meal transcript expression of vitellogenin, effects that were consistent with variably reduced egg clutch sizes and oviposition success from the first through the third gonotrophic cycles. Adult female A. stephensi derived from ABA-treated larvae also exhibited reduced lifespans relative to controls. Collectively, these effects of ABA on A. stephensi life history traits are robust, durable and predictive of multiple impacts of an important malaria vector spreading to new malaria endemic regions.

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Section: Discussionmentioning

confidence: 99%

Comprehensive and Durable Modulation of Growth, Development, Lifespan and Fecundity in Anopheles stephensi Following Larval Treatment With the Stress Signaling Molecule and Novel Antimalarial Abscisic Acid

et al. 2020

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“…Multiple endocrine factors including JH, ILPs, OEH, and 20E coordinate each gonadotrophic cycle (Klowden, 1997; Roy et al. , 2016; Strand et al. , 2016; Zhu & Noriega, 2016).…”

Section: Discussionmentioning

confidence: 99%

“…Previous results indicated that the 8 residue AKH was metabolically active in sugar‐fed female Anopheles gambiae but not the 10 amino acid peptide, which was subsequently identified to be an AKH/corazonin peptide (Kaufmann & Brown, 2006, 2008; Strand et al. , 2016). For this study, the 8‐residue Ae.…”

Section: Methodsmentioning

confidence: 99%

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Multiple endocrine factors regulate nutrient mobilization and storage inAedes aegyptiduring a gonadotrophic cycle

et al. 2022

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Anautogenous mosquitoes must blood feed on a vertebrate host to produce eggs. Each gonadotrophic cycle is subdivided into a sugar-feeding previtellogenic phase that produces primary follicles and a blood meal-activated vitellogenic phase in which large numbers of eggs synchronously mature and are laid. Multiple endocrine factors including juvenile hormone (JH), insulin-like peptides (ILPs), ovary ecdysteroidogenic hormone (OEH), and 20-hydroxyecdysone (20E) coordinate each gonadotrophic cycle. Egg formation also requires nutrients from feeding that are stored in the fat body. Regulation of egg formation is best understood in Aedes aegypti but the role different endocrine factors play in regulating nutrient mobilization and storage remains unclear. In this study, we report that adult female Ae. aegypti maintained triacylglycerol (TAG) stores during the previtellogenic phase of the first gonadotrophic cycle while glycogen stores declined. In contrast, TAG and glycogen stores were rapidly mobilized during the vitellogenic phase and then replenishment. Several genes encoding enzymes with functions in TAG and glycogen metabolism were differentially expressed in the fat body, which suggested regulation was mediated in part at the transcriptional level. Gain of function assays indicated that stored nutrients were primarily mobilized by adipokinetic hormone (AKH) while juvenoids and OEH regulated replenishment. ILP3 further showed evidence of negatively regulating certain lipolytic enzymes. Loss of function assays indicated AKH depends on the AKH receptor (AKHR) for function. Altogether, our results indicate that the opposing activities of different hormones regulate nutrient stores during a gonadotrophic cycle in Ae. aegypti.

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“…There have been many studies and reviews regarding insect hormones. Peptide hormone genes and their receptors in insects have been reviewed previously (Riehle et al, 2002;Reiher et al, 2011;Wegener and Veenstra, 2015;Strand et al, 2016). Although there have been several reviews on hormones produced by the intestinal endocrine cells (Wegener and Veenstra, 2015), the most recent literatures has not yet been summarized.…”

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confidence: 99%

Peptide Hormones in the Insect Midgut

Liu

Wang

et al. 2020

Front. Physiol.

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Insects produce many peptide hormones that play important roles in regulating growth, development, immunity, homeostasis, stress, and other processes to maintain normal life. As part of the digestive system, the insect midgut is also affected by hormones secreted from the prothoracic gland, corpus allatum, and various neuronal cells; these hormones regulate the secretion and activity of insects' digestive enzymes and change their feeding behaviors. In addition, the insect midgut produces certain hormones when it recognizes various components or pathogenic bacteria in ingested foods; concurrently, the hormones regulate other tissues and organs. In addition, intestinal symbiotic bacteria can produce hormones that influence insect signaling pathways to promote host growth and development; this interaction is the result of long-term evolution. In this review, the types, functions, and mechanisms of hormones working on the insect midgut, as well as hormones produced therein, are reviewed for future reference in biological pest control.

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Mosquito Peptide Hormones

Cited by 30 publications

References 205 publications

Comprehensive and Durable Modulation of Growth, Development, Lifespan and Fecundity in Anopheles stephensi Following Larval Treatment With the Stress Signaling Molecule and Novel Antimalarial Abscisic Acid

Comprehensive and Durable Modulation of Growth, Development, Lifespan and Fecundity in Anopheles stephensi Following Larval Treatment With the Stress Signaling Molecule and Novel Antimalarial Abscisic Acid

Multiple endocrine factors regulate nutrient mobilization and storage inAedes aegyptiduring a gonadotrophic cycle

Peptide Hormones in the Insect Midgut

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