Mosquitocidal effect of monoterpene ester and its acetyl derivative from Blumea mollis (D. Don) Merr against Culex quinquefasciatus (Diptera: Culicidae) and their insilico studies

Sivanandhan, Subramaniyan; Ganesan, Pathalam; Stalin, Antony; Paulraj, Michael Gabriel; Samuel, Rajan; Balakrishna, K.; Anand, Srinivasan; Boovaragamurthy, Ahilan; Shirota, Osamu; Mahmoud, Ahmed Hossam; Mohammed, Osama B.; Ignacimuthu, S.

doi:10.1016/j.exppara.2021.108076

Cited by 7 publications

(3 citation statements)

References 39 publications

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“…The observed LC 50 and LC 90 values of compounds 1 and 2 on Cx. quinquefasciatus larvae were 1.73, 1.27 and 4.59, 3.33 ppm mortality in 24 h, respectively (Subramaniyan et al 2021). This result was also compared with the previous report by Xiao et al (2012).…”

Section: Discussionmentioning

confidence: 97%

“…Isolated essential oil and alcoholic extract of this plant also showed promising mosquito larvicidal activities (Senthilkumar et al 2008). Previously, few compounds isolated from B. axillaris, such as 4-hydroxy-7-ethoxycarvotanacetone (ethanol extract of the whole plant) (Bohlmann et al 1979), 4hydroxy-7-tigloyloxycarvotanacetone (ethanol extract of the whole plant) (Bohlmann et al 1979), 4R, 5S)-4-hydroxy-7-tigloyloxy carvotan acetone and its acetate derivative 4R, 5S)-4-acetoxy-7-tigloyloxy carvotan acetone, which showed good mosquitocidal activities (Sivanandhan et al 2018(Sivanandhan et al , 2021Subramaniyan et al 2021).…”

Section: Introductionmentioning

confidence: 99%

“…by GC-MS analysis (Onyayade et al 1990).It can be noted that the corresponding tiglate has also been reported from Blumea mollis by Bohlman et al 1979. We have reported from anti-plant fungal activity and mosquitocidal activity of both the tiglate and acetate and its acetate(Subramaniyan et al 2021) Larvicidal activities of the crude hexane extract of B. axillaris…”

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Effect of (4R, 5S) 4-hydroxy-7-angeloyloxycarvatoneacetone from Blumea axillaris (Lam.) DC. plant against An. stephensi and Cx. quinquefasciatus vector mosquitoes (Diptera: Culicidae) and expression of different functional genes

Hillary

Sivanandhan

Ceasar

et al. 2023

Preprint

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The present study was conducted to evaluate the mosquitocidal efficiency using a compound isolated from Blumea axillaris (Lam.) DC. against Culex quinquefasciatus and Anopheles stephensi. The compound isolated from leaves of B. axillaris is (4R, 5S) 4-hydroxy-7-angeloyloxycarvatoneacetone. This isolated compound was exposed to eggs and larvae of An. stephensi and Cx. quinquefasciatus and with different concentrations of 0.5, 1.0, 1.5, and 2.0 ppm. Primarily, the hexane extract of an isolated compound exhibited promising larvicidal activities of LC50 and LC90 values of 155.811 and 566.763 ppm against An. stephensi and 77.215 and 99.653 against Cx. quinquefasciatus at 24 hours. Secondly, the compound isolated from B. axillaris at 2-ppm concentration exhibited LC50 and LC90 values of 0.85 and 3.59 and 1.19 and 3.678 ppm against Cx. quinquefasciatus and An. stephensi larvae, respectively. Furthermore, histopathological studies revealed serious damage to the larval midgut cells in both Cx. quinquefasciatus and An. stephensi (treated with compound). Additionally, it showed 81.0% and 84.2% ovicidal activity against both Cx. quinquefasciatus and An. stephensi eggs at 120 h post-treatment. In addition, we also analyzed the influence of isolated compound on the expression of different functional genes of An. stephensi and Cx. quinquefasciatus namely (1) White (Wh) gene, which is responsible for eye pigmentation; (2) the Glutathione transferase (GST) gene that helps for survival when exposed to any insecticides or pesticides; (3) Cytochrome P450 monooxygenase (CYP450) gene that enhances resistance in mosquitoes to digest pesticides and (4) Esterase (Est) gene, which helps in resistance to the variety of insecticides. These overall studies and results clearly suggest that compounds from B. axillaris could act as good mosquitocidal agents against both Cx. quinquefasciatus and An. stephensi and the compound were also first time reported as mosquitocidal activity.

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Section: Discussionmentioning

confidence: 97%

Section: Introductionmentioning

confidence: 99%

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confidence: 99%

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Effect of (4R, 5S) 4-hydroxy-7-angeloyloxycarvatoneacetone from Blumea axillaris (Lam.) DC. plant against An. stephensi and Cx. quinquefasciatus vector mosquitoes (Diptera: Culicidae) and expression of different functional genes

Hillary

Sivanandhan

Ceasar

et al. 2023

Preprint

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Chemical Composition, Anti‐Microbial, and Cytotoxic Activities of Essential Oils from Blumea densiflora var. hookeri (C.B. Clarke ex Hook.f.) C.C. Chang & Y.Q. Tseng Leaves from Vietnam

Binh,

Diep,

Van Ngoc

2024

Chemistry & Biodiversity

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The essential oil from the leaves of Blumea densiflora var. hookeri was analyzed using GC–MS, and bioassays were performed. GC‐MS identified thirty‐four constituents, representing 98.7% of the oil composition. The major compounds identified in the oil were (E)‐caryophyllene (15.3%), viridiflorol (5.5%), trans‐dauca‐4(11),7‐diene (4.6%), spathulenol (4.4%), and isolongifolan‐7‐α‐ol (4.3%). The antimicrobial activity of the oil was assessed to determine its efficacy against six bacterial strains and one fungal strain using minimum inhibitory concentration (MIC) methods. The essential oil demonstrated antimicrobial activity against all tested microorganisms. A cytotoxicity assay was performed on KB and A549 cancer cell lines using the MTT method. The essential oil displayed strong cytotoxic effects on both cell lines, with IC50 values of 1.40 ± 0.05 μg/mL for KB and 1.72 ± 0.04 μg/mL for A549.

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Biosynthesis and Biological Activities of Carvone and Carvotanacetone Derivatives

Tahri

Elhouiti

Chelghoum

et al. 2022

Rev. Bras. Farmacogn.

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Mosquitocidal effect of monoterpene ester and its acetyl derivative from Blumea mollis (D. Don) Merr against Culex quinquefasciatus (Diptera: Culicidae) and their insilico studies

Cited by 7 publications

References 39 publications

Effect of (4R, 5S) 4-hydroxy-7-angeloyloxycarvatoneacetone from Blumea axillaris (Lam.) DC. plant against An. stephensi and Cx. quinquefasciatus vector mosquitoes (Diptera: Culicidae) and expression of different functional genes

Effect of (4R, 5S) 4-hydroxy-7-angeloyloxycarvatoneacetone from Blumea axillaris (Lam.) DC. plant against An. stephensi and Cx. quinquefasciatus vector mosquitoes (Diptera: Culicidae) and expression of different functional genes

Chemical Composition, Anti‐Microbial, and Cytotoxic Activities of Essential Oils from Blumea densiflora var. hookeri (C.B. Clarke ex Hook.f.) C.C. Chang & Y.Q. Tseng Leaves from Vietnam

Biosynthesis and Biological Activities of Carvone and Carvotanacetone Derivatives

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