Hydrogen, with its high energy density and environmentally friendly nature, holds great promise as a future energy. The development of efficient catalysts for the hydrogen evolution reaction (HER) in water splitting is necessary. In this study, we focused on synthesizing a hybrid material MoSSe-Graphene (MoSSe-Gr) as a catalyst for HER. The MoSSe-Gr hybrid catalyst was synthesized through a solvothermal method followed by calcination under an inert atmosphere at 800 °C. Morphology and structural analysis of the catalyst was analyzed using SEM, TEM, XRD and Raman spectroscopy. The MoSSe-Gr hybrid catalyst exhibited remarkable catalytic activity for HER, showing significantly lower overpotentials of 90 mV and 200 mV at current densities of 1 and 10 mA cm−2, respectively, comparable to the benchmark Pt/C catalyst. Furthermore, the MoSSe-Gr catalyst demonstrated long-term electrochemical stability during HER over a 24 h period in an acidic medium. Furthermore, the MoSSe-Gr catalyst demonstrated long-term electrochemical stability during HER in 24 h duration in an acidic medium. The MoSSe-Gr hybrid catalyst shows great potential as an efficient and stable catalyst for HER, promoting sustainable hydrogen production.