Most cited articles: ethanol-induced hepatotoxicity, anticarcinogenic effects of polyphenolic compounds in tea, dose–response modeling, novel roles of epoxide hydrolases and arsenic-induced suicidal erythrocyte death

Bolt, Hermann M.; Hengstler, Jan G.

doi:10.1007/s00204-011-0784-0

Cited by 4 publications

(2 citation statements)

References 49 publications

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“…In particular, the occurrence of high As concentrations in groundwaters of Southeast Asia has received much attention in the past decade (Kim et al, 2011[ 43 ]). Therefore, arsenic is a high-priority matter for toxicological research in a number of countries (Bolt and Hengstler, 2011[ 10 ]).…”

Section: Historical Remarksmentioning

confidence: 99%

Contemporary trends in toxicological research on arsenic

Bolt

Hengstler

2018

Arch Toxicol

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There is a plethora of recent publications on all aspects relevant to the toxicology of arsenic (As). Over centuries exposures to arsenic continue to be a major public health problem in many countries. In particular, the occurrence of high As concentrations in groundwater of Southeast Asia receives now much attention. Therefore, arsenic is a high-priority matter for toxicological research. Key exposure to As are (traditional) medicines, combustion of As-rich coal, presence of As in groundwater, and pollution due to mining activities. As-induced cardiovascular disorders and carcinogenesis present themselves as a major research focus. The high priority of this issue is now recognized politically in a number of countries, research funds have been made available. Also experimental research on toxicokinetics and toxicodynamics and on modes of toxic action is moving very rapidly. The matter is of high regulatory concern, and effective preventive measures are required in a number of countries.

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Section: Historical Remarksmentioning

confidence: 99%

Contemporary trends in toxicological research on arsenic

Bolt

Hengstler

2018

Arch Toxicol

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“…Oxidative stress and apoptotic mechanisms appear to play a major role (Bolt and Hengstler 2011). Just recently this year, Sinha et al (2013) presented a review collecting evidence that the cellular redox state and associated complications are closely associated with Nrf2 and its different molecular responses.…”

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confidence: 99%

Current research trends on arsenic toxicology

Bolt

2013

Arch Toxicol

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High exposure to inorganic arsenic by food: the need for risk reduction

Gundert‐Remy

Damm

Foth³

et al. 2015

Arch Toxicol

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Arsenic is a human carcinogen that occurs ubiquitously in soil and water. Based on epidemiological studies, a benchmark dose (lower/higher bound estimate) between 0.3 and 8 μg/kg bw/day was estimated to cause a 1 % increased risk of lung, skin and bladder cancer. A recently published study by EFSA on dietary exposure to inorganic arsenic in the European population reported 95th percentiles (lower bound min to upper bound max) for different age groups in the same range as the benchmark dose. For toddlers, a highly exposed group, the highest values ranged between 0.61 and 2.09 µg arsenic/kg bw/day. For all other age classes, the margin of exposure is also small. This scenario calls for regulatory action to reduce arsenic exposure. One priority measure should be to reduce arsenic in food categories that contribute most to exposure. In the EFSA study the food categories 'milk and dairy products,' 'drinking water' and 'food for infants' represent major sources of inorganic arsenic for infants and also rice is an important source. Long-term strategies are required to reduce inorganic arsenic in these food groups. The reduced consumption of rice and rice products which has been recommended may be helpful for a minority of individuals consuming unusually high amounts of rice. However, it is only of limited value for the general European population, because the food categories 'grain-based processed products (non rice-based)' or 'milk and dairy products' contribute more to the exposure with inorganic arsenic than the food category 'rice.' A balanced regulatory activity focusing on the most relevant food categories is required. In conclusion, exposure to inorganic arsenic represents a risk to the health of the European population, particularly to young children. Regulatory measures to reduce exposure are urgently required.

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Most cited articles: ethanol-induced hepatotoxicity, anticarcinogenic effects of polyphenolic compounds in tea, dose–response modeling, novel roles of epoxide hydrolases and arsenic-induced suicidal erythrocyte death

Cited by 4 publications

References 49 publications

Contemporary trends in toxicological research on arsenic

Contemporary trends in toxicological research on arsenic

Current research trends on arsenic toxicology

High exposure to inorganic arsenic by food: the need for risk reduction

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