Most lepidopteran neuroparsin genes seem functional, but in some domesticated silkworm strains it has a fatal mutation

Veenstra, Jan A.

doi:10.1016/j.ygcen.2019.113274

Cited by 1 publication

(2 citation statements)

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“…A respective total of 63 and 67 neuropeptide precursors were predicted and annotated in G. mellonella from the genome and transcriptome, in which 40 neuropeptide precursors were confirmed in the G. mellonella peptidome. The identified precursors only 10 have been previously reported in G. mellonella, including corazonin (Hansen et al, 2001), SIFamide (Verleyen et al, 2004), allatotropin (AT), FMRFamide, kinin, myosupressin, pyrokinin, allatostatin A, NPF1 (Huybrechts et al, 2005), and neuroparsin (Veenstra, 2020). This study comprehensively identifies peptidomic in G. mellonella.…”

Section: Discussionmentioning

confidence: 73%

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Genomics, transcriptomics, and peptidomics of the greater wax moth Galleria mellonella neuropeptides and their expression in response to lead stress

Luo,

Lin,

Linghu

et al. 2023

Insect Science

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Neuropeptides are crucial in regulation of a rich variety of developmental, physiological, and behavioral functions throughout the life cycle of insects. Using an integrated approach of multiomics, we identified neuropeptide precursors in the greater wax moth Galleria mellonella, which is a harmful pest of honeybee hives with a worldwide distribution. Here, a total of 63 and 67 neuropeptide precursors were predicted and annotated in the G. mellonella genome and transcriptome, in which 40 neuropeptide precursors were confirmed in the G. mellonella peptidome. Interestingly, we identified 12 neuropeptide precursor genes present in G. mellonella but absent in honeybees, which may be potential novel pesticide target sites. Honeybee hives were contaminated with heavy metals such as lead, enabling its bioaccumulation in G. mellonella bodies through the food chain, we performed transcriptome sequencing to analyze the effects of Pb stress on the mRNA expression level of G. mellonella neuropeptide precursors. After treatment by Pb, the expression of neuropeptide F1 was found to be significantly downregulated, implying that this neuropeptide might be associated with responding to the heavy metal stress in G. mellonella. This study comprehensively identified neuropeptide precursors in G. mellonella, and discussed the effects of heavy metals on insect neuropeptides, with the example of G. mellonella. The results are valuable for future elucidation of how neuropeptides regulate physiological functions in G. mellonella and contribute to our understanding of the insect's environmental plasticity and identify potential new biomarkers to assess heavy metal toxicity in insects.

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Section: Discussionmentioning

confidence: 73%

“…, 2004), allatotropin (AT), FMRFamide, kinin, myosupressin, pyrokinin, allatostatin A, NPF1 (Huybrechts et al. , 2005), and neuroparsin (Veenstra, 2020). This study comprehensively identifies peptidomic in G. mellonella .…”

Section: Discussionmentioning

confidence: 99%