Mother–child immunological interactions in early life affect long-term humoral autoreactivity to heat shock protein 60 at age 18 years

Victora, Gabriel D.; Bilate, Angelina M.; Socorro-Silva, A.; Caldas, Cristina; Lima, Rosângela C; Kalil, Jorge; Coelho, Verônica; Victora, César G.

doi:10.1016/j.jaut.2007.02.018

Cited by 19 publications

(18 citation statements)

References 26 publications

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“…These data should be compared and contrasted not only with the mechanisms of autoimmunity, but also specificities of autoantibodies and their genetic basis in other diseases [22][23][24][25][26][27][28][29][30][31][32][33][34][35].…”

Section: Discussionmentioning

confidence: 99%

Comparison of Three Anti-CCP Antibody Tests and Rheumatoid Factor in RA and Control Patients

Correia¹,

Carvalho²,

Fortuna

et al. 2007

Clinic Rev Allerg Immunol

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Sera from 86 RA patients and 90 control patients with other diseases, such as infections, connective tissue diseases, or other rheumatic diseases, were analysed using the four different methods. Specificity (84.4%) and PPV (80.3%) were lowest for RF IgM and highest for EliA CCP (specificity 97.8%, PPV 96.7%), the other values being close to those of EliA CCP. Sensitivity was highest for Quanta Lite CCP (73.3%). Efficiency was highest for Quanta Lite CCP (84.1%) at the lower cut off followed by EliA CCP at both cut offs (83.0%). The discrimination between RA sera (mean value 407.67 U/ml) and control sera (4.54 U/ml) and the relative risk (23.34) were best for EliA CCP. The results of this study reveal that there was no advantage of the anti-CCP antibodies assay applying a new antigen mixture (Quanta Lite CCP 3 ELISA) compared to two second generation anti-CCP antibodies assays (Quanta Lite CCP ELISA and EliA CCP).

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Section: Discussionmentioning

confidence: 99%

Comparison of Three Anti-CCP Antibody Tests and Rheumatoid Factor in RA and Control Patients

Correia¹,

Carvalho²,

Fortuna

et al. 2007

Clinic Rev Allerg Immunol

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“…2. Healthy individuals harbor both antibodies and T cells reactive to self Hsp65, and soluble circulating Hsp (Abulafia-Lapid et al 1999;Luna et al 2007b;Merbl et al 2007;Victora et al 2007). Autoreactivity to Hsp may have a role in maintaining homeostasis and in immunoregulation, as proposed in the theory of the 'Immunological homunculus' (Cohen and Young 1991;Cohen 2007).…”

Section: Summary Of the Workhop Proceedingsmentioning

confidence: 99%

Heat-shock proteins: Inflammatory versus regulatory attributes

Coelho

Broere

Binder

et al. 2008

Cell Stress and Chaperones

Self Cite

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“…Later in life, provided that the events remain inside the frame of the so-called functional window, even in the elderly, the condition of the IDS will not be marginal either. The theme cannot be omitted in any discussion about autoimmunity induction [44][45][46].…”

Section: Timings With Respect To Autoimmunitymentioning

confidence: 99%

A Propos Time and Autoimmunity

Martı́n

Malizia

Rewald

2007

Clinic Rev Allerg Immunol

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The integrated defense system has been shaped over eons showing noteworthy robustness by surviving a million-year prehistory, a comparatively short evolving history and current transformation. Self-identification being part of it, so are deviations manifold expressed in autoimmunity. Epidemiological incidence and intensity, both being subject of change, are focused in the light of the time factor. Furthermore, it is stressed that there is no bi-univocal mutual relationship between immunity and defense and the origins of autoimmunity still remain mysterious. We question whether the present transforming events have occurred within too short a time to be attributed to genetic predisposition exclusively.

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Mother–child immunological interactions in early life affect long-term humoral autoreactivity to heat shock protein 60 at age 18 years

Cited by 19 publications

References 26 publications

Comparison of Three Anti-CCP Antibody Tests and Rheumatoid Factor in RA and Control Patients

Comparison of Three Anti-CCP Antibody Tests and Rheumatoid Factor in RA and Control Patients

Heat-shock proteins: Inflammatory versus regulatory attributes

A Propos Time and Autoimmunity

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