Mother-infant interaction in mice bulbectomised early in life

Pattern of Compensatory Expression of Voltage-Dependent Ca2+ Channel .ALPHA.1 and .BETA. Subunits in Brain of N-type Ca2+ Channel .ALPHA.1B Subunit Gene-Deficient Mice with a CBA/JN Genetic Background

“…Although it seems that the occurrence of compensation via enhanced expression of α 1A and β 4 subunit genes is dependent on the genetic background, the P/Q-type Ca 2+ channel seems to have a compensatory role in cerebellum of N-type Ca 2+ channel α 1B -deficient mice with CBA/JN, CBA × C57BL/6, and CBA × C57BL/6 × ICR backgrounds. The olfactory bulb is reported to play an important role in odor-guided behavior, including neonatal growth, survival and weaning [2,3]. In this study, the numbers of (+/+), (+/-), and (-/-) weaned mice from (+/-) mice with a CBA/JN background were consistent with Mendelian segregation, the ratio of females and males was 1:1, and the litter size was normal.…”

Effects of Neonatal Bulbectomy on Later Discrimination Learning in Mice

“…They ran the maze rapidly, paused at tire centre only briefly and seldom failed to run the maze in the time allowed. Their behaviour, while typical of that o f parent generation under nourished rats (10), was radically different from the bulbectomised mice and suggests that the slow growth consequent upon the restric tion of food intake in the one instance and tire impairment o f suckling that accompanies neonatal bulbectomy on the other are not expressed in the behaviour o f adult animals in the same way (see also 4,5,8,9). The mice with a history o f undernourishment actively explored the goal box and attempted to re enter the maze, behaviour that was less obvious in the other samples.…”

“…The placement of lesions in the olfactory bulbs o f neonatal rats and mice also leads to a retardation of growth, and sexual maturation is delayed (4,5,8). The factors responsible for the failure of normal growth relate both to the slowness of the animals to reach and attach themselves to the mother's nipple and to changes in feeding which in turn no doubt aggravate the difficulties in obtaining adequate food supplies.…”

Genetic Background Influences P/Q-type Ca2+ Channel α1A Subunit mRNA Expression in Olfactory Bulb and Reproductive Ability of N-type Ca2+ Channel α1B Subunit-Deficient Mice

“…Because it has been reported that the olfactory bulb plays an important role in odor-guided behavior, including mating, pregnancy, neonatal growth, survival, and weaning (Cooper and Cowley, 1986;Doty, 1986;Larsson, 1975), we examined the numbers of offspring from mating a female +/+ and a male +/+, a female −/− and a male +/+, a female +/+ and a male −/−, or a female −/− and a male −/− pair with CBA/JN backgrounds. The duration of mating was four months (8-24 weeks of age).…”