Mother’s obesity and high child’s waist circumference are predictive factors of severe child’s obesity: an observational study in French Guiana

Njuieyon, Falucar; Cuadro-Alvarez, Emma; Martin, Élise; Lachaume, Noémie; Mrsic, Yajaira; Henaff, Fanny; Maniassom, Chimène; Defo, Antoine; Elenga, Narcisse

doi:10.1186/s12887-018-1158-z

Cited by 3 publications

(1 citation statement)

References 45 publications

(33 reference statements)

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“…This finding is consistent with those described by Parikka et al (Parikka et al, 2015). Njuieyon et al have described the maternal excess weight as a predictor of metabolically abnormal obesity (Njuieyon et al, 2018). On the other hand, all of our respondents are participants of the Weight Correction Program and their data were gathered on the first day of programme.…”

Section: Discussionsupporting

confidence: 92%

Parental Weight Status, Birth Weight and Depression Signs Influence on Child’s z-BMI

et al. 2019

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Objectives: Overweight and obesity has become an important worldwide health issue, that is why the risk factors for gaining excess weight are being studied a lot. Big birth weight and parental overweight are known risk factors for childhood overweight. The association between psychological issues and excess weight is bidirectional. Aim of our research was assessing if there was any association between parental weight status, birth weight or signs of depression and the exact value of already overweight child’s standardized body mass index (z-BMI). Study design: Cross-sectional study. Materials and Methods: All 303 respondents included were six to seventeen years old patients of the first weight correction programme in Baltic states. Their first day data were gathered from Children’s Clinical University Hospital electronic databases Andromeda and Saule, as well as from outpatient medical records. Height and weight data were turned into z-BMI. Depression signs had been assessed using Children Depression Inventory (by M. Kovacs, 1992). Parental weight status and child’s birth weight had also been documented. Results: From all 303 respondents 141 (47%) were boys. Median age 12 (IQR 10-15) years. The median z-BMI was significantly higher in boys than in girls (2.97 (IQR 2.59-3.37) vs. 2.59 (IQR 2.13-2.90), p<0.001). Parental weight status correlated significantly with z-BMI value in boys (r=0.17, p=0.043) and in girls (r=0.18, p=0.026). The correlation became stronger when controlled by birth weight and signs of depression: r=0.87, p=0.005 for boys; r=0.96, p<0.001 for girls. There was no significant correlation between z-BMI and either birth weight or signs of depression. Conclusions: The parental excess weight correlated significantly with the z-BMI of their son or daughter. The signs of depression and birth weight had no significant association with z-BMI.

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Section: Discussionsupporting

confidence: 92%

Parental Weight Status, Birth Weight and Depression Signs Influence on Child’s z-BMI

et al. 2019

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About the need to address pediatric health inequalities in French Guiana : a scoping review

Osei

Basurko

Vignier

et al. 2022

Archives de Pédiatrie

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Amino acid variants in the HLA-DQA1 and HLA-DQB1 molecules explain the major association of variants with relapse status in pediatric patients with steroid-sensitive nephrotic syndrome

Yin,

Yu,

Chen

et al. 2024

Preprint

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Background Management of patients with steroid-sensitive nephrotic syndrome (SSNS) is challenging because of frequent relapses. Causal variants in the human leukocyte antigen (HLA) class II region that are associated with relapse remain undetermined. Methods We collected a cohort of East Asian individuals comprising 206 pediatric patients with SSNS and 435 healthy controls from Southwest China. Ninety children with steroid-sensitive nephrotic syndrome without relapse (SSNSWR) and 116 children with steroid-dependent and/or frequent relapse nephrotic syndrome (SDNS/FRNS) were genotyped using Sanger sequencing. We then measured the transcriptional level, allele expression imbalance (AEI) and functional proteins of HLA-DQA1 and HLA-DQB1 in different stages of SDNS/FRNS. Results rs1464545187 in ANKRD36 was associated with an approximately 1.69-fold greater risk for SSNSWR (P=0.04; 95% confidence interval [CI], 1.05-2.72). Clustered risk variants in HLA-DQA1 and HLA-DQB1 were significantly associated with SDNS/FRNS (rs1047989: P=2.26E-07, odds ratio [OR]=2.25, 1.65-3.05; rs9273471: P=5.45E-05, OR=1.84, 1.37-2.46; HLA-DQB1*06:02: P=0.017, OR=0.19, 0.04-0.77). The genotype distributions of rs1047989, 2:171713702, rs1049123, rs9273471, and HLA-DQB1*06:02 in patients with SSNS were significantly different from those in healthy controls. rs1047989 (HLA-DQA1) was significantly associated with a greater number of infections at relapse in SDNS/FRNS patients (P=0.045, OR=6.79, 95% CI: 1.29-168.52). Flow cytometry showed that the proportion of cells expressing HLA-DQA1+/DQB1+ (HLA-DQA1+, P=0.0046; HLA-DQB1+, P=0.0045) was lowest in the relapse stage. In addition, the mRNA levels of HLA-DQA1 and HLA-DQB1 were significantly greater in the relapse group than in the remission group (HLA-DQA1, P=0.03; HLA-DQB1, P=0.002). No significant AEIs were detected in the different stages of SDNS/FRNS. The rs1047989 variant is likely to affect the structure and stability of HLA-DQA1. Conclusion rs1464545187 is a risk locus for SSNSWR but not SDNS/FRNS in Chinese children. Functional variations in HLA-DQA1 and HLA-DQB1 are implicated in regulating the immune response of SSNS patients, which may explain the typical triggering of SDNS/FRNS onset by infections.

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Mother’s obesity and high child’s waist circumference are predictive factors of severe child’s obesity: an observational study in French Guiana

Cited by 3 publications

References 45 publications

Parental Weight Status, Birth Weight and Depression Signs Influence on Child’s z-BMI

Parental Weight Status, Birth Weight and Depression Signs Influence on Child’s z-BMI

About the need to address pediatric health inequalities in French Guiana : a scoping review

Amino acid variants in the HLA-DQA1 and HLA-DQB1 molecules explain the major association of variants with relapse status in pediatric patients with steroid-sensitive nephrotic syndrome

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