Mother-to-child transmission of HIV: the pre-rapid advice experience of the university of Nigeria teaching hospital Ituku/Ozalla, Enugu, South-east Nigeria

Ibeziako, Ngozi; Ubesie, Agozie C; Emodi, IJ; Ayuk, Adaeze C; Iloh, Kene K; Ikefuna, AN

doi:10.1186/1756-0500-5-305

Cited by 4 publications

(5 citation statements)

References 14 publications

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“…In that study, blood transfusion accounted for as much as 68% of the pediatric HIV infection. Our current study supports the new thinking that eliminating paediatric HIV will therefore require strengthening interventions that reduces MTCT of HIV [12,13].…”

Section: Discussionsupporting

confidence: 79%

Clinical and Laboratory Profile of ARV Naive HIV Infected Children in the Era of Highly Active Anti-retroviral Therapy in Enugu, South-East Nigeria

Ubesie

2014

IJTDH

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Background: HIV/AIDS is one of the most dynamic epidemic infectious diseases. An estimated 1000 children are newly infected with HIV every day, most of them in sub-Saharan Africa. They often present with various clinical and laboratory manifestations that complicates their management. Objectives: To determine the baseline clinical and laboratory features of HIV-infected children presenting at the University of Nigeria Teaching Hospital (UNTH) Ituku/Ozalla. Methods: Clinical and laboratory data were collected from HIV infected children seen at the Pediatric HIV Clinic of UNTH between July 1st 2010 and June 30th 2012. Clinical and immunological staging of the patients were done using the WHO criteria and data analysis was with SPSS version19. Results: Two hundred and ten children were enrolled into the study. The most common route of HIV infection was vertical transmission (95.2%). Common presenting clinical and

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Section: Discussionsupporting

confidence: 79%

Clinical and Laboratory Profile of ARV Naive HIV Infected Children in the Era of Highly Active Anti-retroviral Therapy in Enugu, South-East Nigeria

Ubesie

2014

IJTDH

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“…The study of Ngozi et al showed that holistic but cost effective preventive interventions help in reducing the rate of mother-to-child transmission of HIV even in economically-developing settings [23]. Turan et al found that PMTCT of HIV and antenatal care integration in pregnancy might improve the implementation and effectiveness of PMTCT in rural area [24].…”

Section: Discussionmentioning

confidence: 99%

Effectiveness of a prevention of mother-to-child HIV transmission program in Guangdong province from 2007 to 2010

Zhao

Zhang

et al. 2013

BMC Public Health

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BackgroundTo achieve the goal of United Nations of elimination of new HIV infections, a program of prevention of mother-to-child transmission (PMTCT) was launched in Guangdong province. The objective of this study is to evaluate the effectiveness of the PMTCT program.MethodsThe retrospective cross-section analysis was conducted using the data of case reported cards of HIV positive mothers and their infants from 2007 to 2010 in Guangdong province, and 108 pairs of eligible subjects were obtained. We described the data and compared the rates of MTCT by various PMTCT interventions respectively.ResultsThe overall rate of HIV MTCT was 13.89% (15) among 108 pairs of HIV positive mothers and their infants; 60.19% (65) of the mothers ever received ARVs, 80.56% (87) of infants born to HIV positive mothers ever received ARVs, but 16.67% (18) of the mothers and infants neither received ARVs. Among all the mothers and infants, who both received ARVs, received triple ARVs, mother received ARVs during pregnancy, and both received ARVs and formula feeding showed the lower rates of HIV MTCT, and the rates were 8.06%, 2.50%, 5.77%, and 6.67% respectively. In infants born to HIV positive mother, who received mixed feeding had a higher HIV MTCT up to 60.00%. Delivery mode might not relative to HIV MTCT.ConclusionsThe interventions of PMTCT program in Guangdong could effectively reduce the rate of HIV MTCT, but the effectiveness of the PMTCT program were heavily cut down by the lower availability of the PMTCT interventions.

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“…The study by Tudor et al describes, for example, that integrated PMTCT services could effectively reduce mother-to-child transmission of HIV [33]. Ibeziako et al have shown that holistic but cost-effective prevention interventions help reduce the rate of mother-to-child transmission of HIV, even in economically developing countries [34]. These measures will achieve a reduction or even eradication of mother-to-child transmission of HIV [35].…”

Section: Discussionmentioning

confidence: 99%

Mother-child HIV-1 transmission in the departments of Mono and Couffo in Benin: incidence and associated factors in 2019

Koudokpon

Dougnon

Kissira

et al. 2020

Preprint

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Background: Despite worldwide success of introducing HIV testing and treatment with antiretroviral drugs, HIV remains a real public health problem. Vertical mother-child transmission is a form responsible for many cases of new infections. This study was therefore carried out in order to reduce the prevalence of mother-to-child transmission of HIV-1 in the departments of Mono and Couffo. Method: For this purpose, a total of 374 dry blood spots (DBS) were collected from infants born to HIV-positive mothers during the year 2019, and these DBS were used for the molecular diagnosis of HIV1 in these infants. Information on the type of treatment, the type of diet of infants was also collected. The viral loads of the mothers before delivery were determined after the last antenatal visits. To do so, a venous blood sample was taken from an EDTA tube. These different samples were used for DNA extraction. The early diagnosis of these infants as well as the determination of the viral load were carried out by RT-PCR using the Roche automated system. The results were analyzed with the chi-square test on the SPSS software. Result: The results showed that 51% of the newborns included in the study were male and the vast majority of the newborns were in the 0-6 month age group. 93.41% of the newborns included in this study were tested negative for early detection by RT-PCR. Significant links were observed between the early diagnosis of newborns and the mother's mode of feeding, the PMTCT protocol, and the viral load of the mothers. Monoprophylaxis was predominant in the newborn PMTCT protocol (96.28%). Conclusion: The national program for the prevention of vertical transmission of HIV from mother to child deserves to be continued and strengthened with the objective of zero newborns infected at birth in the departments of Mono and Couffo.

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Mother-to-child transmission of HIV: the pre-rapid advice experience of the university of Nigeria teaching hospital Ituku/Ozalla, Enugu, South-east Nigeria

Cited by 4 publications

References 14 publications

Clinical and Laboratory Profile of ARV Naive HIV Infected Children in the Era of Highly Active Anti-retroviral Therapy in Enugu, South-East Nigeria

Clinical and Laboratory Profile of ARV Naive HIV Infected Children in the Era of Highly Active Anti-retroviral Therapy in Enugu, South-East Nigeria

Effectiveness of a prevention of mother-to-child HIV transmission program in Guangdong province from 2007 to 2010

Mother-child HIV-1 transmission in the departments of Mono and Couffo in Benin: incidence and associated factors in 2019

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