MOTHERISK ROUNDS: The Fetal Safety of Fluoxetine: A Systematic Review and Meta-Analysis

Riggin, Lauren; Frankel, Zipora; Moretti, Myla E; Pupco, Anna; Koren, Gideon

doi:10.1016/s1701-2163(15)30965-8

Cited by 43 publications

(22 citation statements)

References 58 publications

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“…However, according to another meta-analysis, fluoxetine does not appear to increase the overall risk for congenital defects. 32 Three meta-analyses in the literature have reported odds ratios between 1.12 (95%CI 0.98-1.28) and 1.25 (95%CI 1.03-1.51) for congenital defects associated with fetal exposure to fluoxetine. 27,28,32 Although there are conflicting reports published, a greater number of studies on the use of paroxetine describe deleterious effects such as increased risk of cardiac malformations.…”

Section: Congenital Malformationsmentioning

confidence: 99%

“…32 Three meta-analyses in the literature have reported odds ratios between 1.12 (95%CI 0.98-1.28) and 1.25 (95%CI 1.03-1.51) for congenital defects associated with fetal exposure to fluoxetine. 27,28,32 Although there are conflicting reports published, a greater number of studies on the use of paroxetine describe deleterious effects such as increased risk of cardiac malformations. 24,[26][27][28]31,[33][34][35] This increased risk is also supported by two recent meta-analyses (reported OR = 1.43, 95%CI 1.08-1.88 and 1.44, 95%CI 1.12-1.86).…”

Section: Congenital Malformationsmentioning

confidence: 99%

“…27,28 The OR for the same defects in fluoxetine users was reported to be 1.17-1.60 by three meta-analyses. 27,28,32 Based on their meta-analysis, Myles et al 27 have recommended against elective use of both paroxetine and fluoxetine as first-line antidepressant therapy in the first trimester of pregnancy. To date, similar meta-analysis data are not available for sertraline and citalopram.…”

Section: Congenital Malformationsmentioning

confidence: 99%

“…91 Several studies have suggested an approximately 2-fold increased risk of cardiovascular defects associated with clomipramine, although these studies have some methodological limitations. [31][32][33][34][35][36][37][38][39][40] Although this is a discouraging factor in the use of this drug, the absolute risk of cardiovascular defects is still low. In addition, clomipramine is related to higher risk of PNAS compared to other TCAs.…”

Section: Drug Optionsmentioning

confidence: 99%

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Pharmacotherapy of obsessive-compulsive disorder during pregnancy: a clinical approach

Uğuz

2015

Rev. Bras. Psiquiatr.

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Obsessive-compulsive disorder (OCD) is a relatively common psychiatric disorder in the perinatal period. However, specific pharmacological treatment approaches for patients with OCD during pregnancy have not been satisfactorily discussed in the literature. In addition, there are no randomized controlled studies on the treatment of this disorder during pregnancy. The present paper discusses the pharmacological treatment of OCD in the light of data on the safety of antipsychotics and serotonergic antidepressants during pregnancy and their efficacy in the non-perinatal period. Treatment decisions should be individualized because the risk-benefit profile of pharmacotherapy is an important issue in the treatment of pregnant women with any psychiatric diagnosis.

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Section: Congenital Malformationsmentioning

confidence: 99%

Section: Congenital Malformationsmentioning

confidence: 99%

Section: Congenital Malformationsmentioning

confidence: 99%

Section: Drug Optionsmentioning

confidence: 99%

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Pharmacotherapy of obsessive-compulsive disorder during pregnancy: a clinical approach

Uğuz

2015

Rev. Bras. Psiquiatr.

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“…The majority of prescriptions are for selective serotonin receptor inhibitors (SSRIs). 3 Tricyclic antidepressants (TCAs) are also widely used throughout pregnancy without apparent detriment to the foetus. 4 SSRIs have been associated with spontaneous abortion.…”

Section: Introductionmentioning

confidence: 99%

Carneous mole in a depressed patient: a diagnostic dilemma

Bhagat

Raj

2017

Int J Reprod Contracept Obstet Gynecol

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Carneous mole is a pathological variant of missed abortion of a fetus less than 12 weeks. It’s medically managed by giving repeated doses of misoprostol with or without dilatation and curettage. Due to ambiguity in diagnosis and misleading clinical examination and investigations, surgical exploration was considered as the best approach. The case of carneous mole with depression is reported because of its rarity; as in this case, ammenorrhea was the only presenting complaint and all other laboratory tests, investigations and radiological report failed to detect carneous mole, which was diagnosed incidentally on exploratory laparotomy.

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