Motherless rats show deficits in maternal behavior towards fostered pups

Palombo, Daniela J.; Nowoslawski, Michael; Fleming, Alison S.

doi:10.1002/dev.20422

Cited by 26 publications

(17 citation statements)

References 23 publications

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“…Offspring of high licking moms become high licking moms (Champagne & Meaney, 2001). Rat pups reared in isolation from their mother and without such stimulation, however, show maternal behavior deficits in behaviors such as crouching and licking (Gonzalez et al, 2001; Melo et al, 2006), an effect that is retained even towards foster pups (Palombo, Nowoslawski, & Fleming, 2010). Furthermore, deficits are related to the degree of early maternal separation with more extreme separation paradigms associated with the most severe behavioral deficits (Lovic et al, 2001; Rees et al, 2008).…”

Section: Maternal Behavior Is Affected By Early Experiences In Fmentioning

confidence: 99%

Annual Research Review: All mothers are not created equal: neural and psychobiological perspectives on mothering and the importance of individual differences

Barrett

Fleming

2010

Child Psychology Psychiatry

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386

358

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Quality of mothering relies on the integrity of multiple physiological and behavioral systems and on two maternal factors, one proximal and one distal, that have a great impact on how a mother mothers: postpartum depression and early experiences. To mother appropriately requires the action of systems that regulate sensation, perception, affect, reward, executive function, motor output and learning. When a mother is at risk to engage in less than optimal mothering, such as when she is depressed or has experienced adversity in childhood, the function of many or all of maternal and related systems may be affected. In this paper, we will review what is currently known about the biological basis of mothering, with attention to literature on hormones but with a particular focus on recent advances in the fields of functional neuroimaging. Instead of discussing strictly 'maternal' brain imaging studies, we instead use a systems approach to survey important findings relevant to brain systems integral to and/or strongly related to the mothering experience: (a) social behavior; (b) reward and affect; (c) executive function; and (d) maternal behavior. We find that there are many commonalities in terms of the brain regions identified across these systems and, as we would expect, all are sensitive to the influence of, or function differently in the context of, depression and adverse early experience. It is likely that the similarity and cross-talk between maternal, affect and stress systems, observed behaviorally, hormonally and in the context of brain function, allows for mood disturbance and early adverse experiences to have a significant impact on the quality of mothering and the motivation to mother.

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Section: Maternal Behavior Is Affected By Early Experiences In Fmentioning

confidence: 99%

Annual Research Review: All mothers are not created equal: neural and psychobiological perspectives on mothering and the importance of individual differences

Barrett

Fleming

2010

Child Psychology Psychiatry

Self Cite

386

358

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“…Given that postnatal maternal care has also been shown to programme stress responsivity and emotionality in the offspring (Champagne & Meaney 2001, Weaver et al 2004) and furthermore to programme subsequent maternal behaviour in female offspring (Champagne & Meaney 2001, Palombo et al 2010, a further consequence of prenatal social stress is the potential transmission of the programmed phenotype to future generations.…”

Section: Maternal Behaviour In Pigsmentioning

confidence: 99%

Effects of maternal exposure to social stress during pregnancy: consequences for mother and offspring

2013

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A suboptimal in utero environment, for example, as a result of maternal stress, can have detrimental effects on the pregnancy and long-term adverse 'programming' effects on the offspring. This article focuses on the effects of prenatal social stress on the mother, her pregnancy and the offspring, since these issues have ethological relevance in both animals and humans. The consequences of social stress exposure depend on when during pregnancy the stress occurs, and many of the effects on the offspring are sex specific. Social stress during early pregnancy tends to result in pregnancy loss, whereas stress exposure later in pregnancy, when the mother has already invested considerable resources in the foetuses, results in programmed offspring of low birth weight: a risk factor for various adulthood diseases. Neuroendocrine and behavioural responses to stress in the offspring are particularly sensitive to foetal programming by prenatal stress, indicated by enhanced hypothalamo-pituitary-adrenal (HPA) axis responses and increased anxiety behaviour, which result from permanent changes in the offspring's brain. The dysregulation of HPA axis function may also interfere with other systems, for example, the hypothalamic-pituitary-gonadal axis, as there is evidence for alterations in steroidogenesis, reproductive potential and impaired reproductive/social behaviours in prenatally stressed offspring. Prenatal social stress also programmes future maternal behaviour, highlighting the potential for negative phenotypes to be transmitted to future generations. The possible mechanisms through which maternal stress during pregnancy is transmitted to the foetuses and the foetal brain is programmed by prenatal stress and the potential to overwrite programming of the offspring are discussed.Reproduction (2013) 146 R175-R189

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“…The maternal brain involves coordination of several neural systems, including oxytocin and dopamine, to approach and respond to infant cues . In rat models, disruption of maternal care through early‐life isolation has been shown to affect offspring behaviour in adulthood, including their maternal behaviour and other dopamine‐dependent behaviour, such as impulsive action, strategy shifting, and baseline reward sensitivity to drugs and sucrose . This impairment in adulthood by early isolation from the mother can be rescued with early‐life supplemental tactile stimulation …”

Section: Introductionmentioning

confidence: 99%

“…[3][4][5] In rat models, disruption of maternal care through early-life isolation has been shown to affect offspring behaviour in adulthood, including their maternal behaviour and other dopaminedependent behaviour, such as impulsive action, strategy shifting, and baseline reward sensitivity to drugs and sucrose. [6][7][8][9][10][11][12] This impairment in adulthood by early isolation from the mother can be rescued with early-life supplemental tactile stimulation. 7,10 Previous research has established that there is natural variation in how rodent mothers respond and care for their pups, measured by the total licking/grooming (LG) of the entire litter during the first postpartum week.…”

mentioning

confidence: 99%

Inter‐individual maternal care received and genotype interactions affect dopaminergic phenotypes in female rat offspring

Lauby

Chatterjee

Pan

et al. 2019

J Neuroendocrinology

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Rat mothers exhibit natural variations in care and can shape offspring adult behaviour and their maternal care by affecting the dopaminergic system. We explored whether genotype and gene × environment interactions are involved in these processes in nulliparous female offspring. We assessed maternal licking/grooming toward individual female pups during the first week postpartum and dopamine‐related behaviour of the offspring in adulthood. Behaviours explored included strategy shifting, impulsive action and sucrose preference. Single nucleotide polymorphisms in the dopamine receptor 2, dopamine transporter and catechol‐O‐methyltransferase genes were examined in relation to offspring behaviour and baseline dopamine turnover in select brain regions. Dopamine receptor 2 (RS107017253) variation moderated, or interacted with, the relationship between early‐life licking received and behaviour. Specifically, offspring with the A/A genotype showed a significant correlation between early‐life licking received and behaviour. Offspring with the A/G and G/G genotypes did not show this relationship. Dopamine transporter gene variation affected offspring behaviour regardless of early‐life licking received. Our findings suggest that genotype can directly affect dopamine‐related behaviours and alter the sensitivity of offspring to the maternal environment. This could be informative on how maternal care is transmitted between generations of female offspring.

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Motherless rats show deficits in maternal behavior towards fostered pups

Cited by 26 publications

References 23 publications

Annual Research Review: All mothers are not created equal: neural and psychobiological perspectives on mothering and the importance of individual differences

Annual Research Review: All mothers are not created equal: neural and psychobiological perspectives on mothering and the importance of individual differences

Effects of maternal exposure to social stress during pregnancy: consequences for mother and offspring

Inter‐individual maternal care received and genotype interactions affect dopaminergic phenotypes in female rat offspring

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