Mothers’ Impressions and Beliefs About Taking a Booster Dose for COVID-19 Vaccine During Pregnancy and Lactation

Abstract

Objectives: This study aimed to explore perceptions and willingness to get coronavirus disease 2019 (COVID-19) booster vaccination among pregnant and lactating women in Jordan.Methods: A cross-sectional study using a 29-item web-based questionnaire was conducted. Sociodemographic characteristics, vaccine acceptance, confidence in the booster dose of COVID-19 vaccine, perception of risk for COVID-19, and acceptance to participate in COVID-19 booster vaccine clinical trials were prospectively evaluated. Logistic regression was used to identify factors that might affect the participants' acceptance of a COVID-19 vaccine and their willingness to enroll in clinical trials of a booster dose of COVID-19 vaccine.Results: Among all participants (pregnant and lactating women, n = 584), 328 (56.2%) intended to receive the booster dose of the COVID-19 vaccine. Predictors of booster dose acceptance were a medical-related degree (OR 1.62, CI 1.06-2.5, p = 0.028), income (OR 0.677, CI 0.52-0.88, p = 0.004), living residency (OR 0.44, CI 0.32-0.60, p < 0.001), knowing pregnant/lactating women previously infected with infectious microbe (OR 1.539, CI 1.07-2.23, p = 0.022), commitment to immunization for children (OR 3.01, CI 1.03-8.82, p = 0.044), receiving an influenza vaccine (OR 1.46, CI 1.04-2.05, p = 0.031), and worried about infectious microbes (OR 1.32, CI 1.15-1.52, p < 0.001). Among participants, only 22.9% were willing to participate in clinical trials of the booster dose of COVID-19 vaccine. The biggest motivator for participation was the participants' desire to help find the best vaccine during pregnancy/lactation (57.5%) while the main barrier towards participation was not wanting to expose themselves and their babies to more side effects (88.0%).Conclusion: This study reported reasonable acceptance of vaccination in a sample of pregnant/lactating women. Vaccination hesitancy for the booster dose was in-line with similar studies on the primary series around the globe, but the willingness to participate in clinical trials was lower than non-pregnant/nonlactating women.

A Systematic Review of Population-Based Studies Assessing Knowledge, Attitudes, Acceptance, and Hesitancy of Pregnant and Breastfeeding Women towards the COVID-19 Vaccine

“…At the end of the screening process, a total of 64 articles were considered included. However, due to the high heterogeneity in terms of outcomes assessed and its definition as well as study setting, we decided to present in the current manuscript only population-based studies (a total of 21 included studies) [ 19 , 20 , 21 , 22 , 23 , 24 , 25 , 26 , 27 , 28 , 29 , 30 , 31 , 32 , 33 , 34 , 35 , 36 , 37 , 38 , 39 ]. Consultation with experts did not add any further eligible studies.…”

“…Nine studies explored attitude toward COVID-19 vaccination and its determinants ( Table 4 ). Two studies assessed attitude toward COVID-19 booster doses [ 38 , 39 ] and its determinant. The positive attitude toward COVID-19 vaccine ranged between 29.7% [ 37 ] and 80% [ 28 ] among pregnant women, and between 38.6% [ 37 ] and 83.4% among breastfeeding women [ 28 ].…”

“…On the other hand, mixed feeding, longer breastfeeding duration, a history of high-risk travel, and better physical health were all associated with higher negative attitude [ 39 ]. Regarding the positive attitude, income and residency were associated with a lower positive attitude, while level of education, previous infection, having received influenza vaccine, worries about infection, and commitment to immunize children were all associated with a higher attitude toward the COVID-19 vaccine [ 38 ] ( Supplementary Table S5 ).…”

“… The overall score and the overall appraisal of quality [ 21 , 22 , 23 , 24 , 25 , 26 , 27 , 28 , 29 , 30 , 31 , 32 , 33 , 34 , 35 , 36 , 37 , 38 , 39 , 40 , 41 ]. …”

Analisis Faktor Yang Mempengaruhi Kesediaan Ibu Hamil dalam Melakukan Vaksinasi COVID-19 Booster di Wilayah Kerja Puskesmas Balongpanggang Kabupaten Gresik

“…Hal ini sejalan dengan penelitian Rzymski pada tahun 2021 individu dengan Pendidikan kurang dari SMA memiliki kemauan untuk divaksin yang lebih rendah daripada kelompok Pendidikan SMA, hal ini dikaitkan dengan Pendidikan yang rendah diikuti dengan pengetahuan yang rendah akan berhubungan dengan keraguan untuk menerima vaksin (Rzymski et al, 2021). Pendidikan yang tinggi menjadi prediktor terkuat ibu hamil untuk menerima vaksinasi Covid-19 Booster dalam penelitian yang dilakukan oleh Taybeh et al pada tahun 2022 di Yordania (Taybeh et al, 2022).…”