Objective: Understanding the meanings attributed by family caregivers of children in hospital environments about their interactions with nursing professionals. Methods: This qualitative study used Symbolic Interactionism as a theoretical reference and Grounded Theory as the methodological framework. It was carried out in a Pediatrics Center in southern Brazil, in the first half of 2013. Participants were 15 family caregivers of hospitalized children. Data were collected through interviews and submitted to open and axial analysis. Results: Interactions with the nursing team enable family to trust or distrust in the provided child care and to positively evaluate the care received. Conclusion: Interactions between family members and the nursing team contribute to the significance attributed by the family to the nursing care received by the child. Nurses should be aware of the attitudes of the nursing team regarding the child and their family, prioritizing humanized care.