Motile curved bacteria are Pareto-optimal

Schuech, Rudi; Hoehfurtner, Tatjana; Smith, D. J.; Humphries, Stuart

doi:10.1073/pnas.1818997116

Cited by 59 publications

(35 citation statements)

References 53 publications

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“…Therefore, noninitialized 3-h-incubated C. albicans were randomly distributed across the channel in the expansion region, even beyond the centerline of the microchannel (see Supplementary Materials, Figure S2). Although an asymmetrical coefficient was adopted to evaluate the curved shape of candida cells in this study, it is worth examining the effect of asymmetry of candida cells on flow characteristics through analytical and experimental studies (as a potential future work) [56].…”

Section: Resultsmentioning

confidence: 99%

Sheathless Shape-Based Separation of Candida Albicans Using a Viscoelastic Non-Newtonian Fluid

et al. 2019

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Rapid and accurate identification of Candida albicans from among other candida species is critical for cost-effective treatment and antifungal drug assays. Shape is a critical biomarker indicating cell type, cell cycle, and environmental conditions; however, most microfluidic techniques have been focused only on size-based particle/cell manipulation. This study demonstrates a sheathless shape-based separation of particles/cells using a viscoelastic non-Newtonian fluid. The size of C. albicans was measured at 37 °C depending on the incubation time (0 h, 1 h, and 2 h). The effects of flow rates on the flow patterns of candida cells with different shapes were examined. Finally, 2-h-incubated candida cells with germ tube formations (≥26 μm) were separated from spherical candida cells and shorter candida cells with a separation efficiency of 80.9% and a purity of 91.2% at 50 μL/min.

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Section: Resultsmentioning

confidence: 99%

Sheathless Shape-Based Separation of Candida Albicans Using a Viscoelastic Non-Newtonian Fluid

et al. 2019

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“…As such, it would be interesting to consider rototaxis in scenarios involving more complex rotational flows with differential vorticity, alternative particle geometries (47,69,70) and D R A F T their possible time dependent adaptations, and many body effects in the presence of repulsive and alignment interactions (71,72). In even more general flow fields u( r) our methods may be useful to study general kinotaxis (alignment along ∇ u 2 ( r) towards the gradient of kinetic flow energy) and enstrotaxis (alignment along ∇(∇ × u( r)) 2 towards the gradient of the enstrophy).…”

Section: Discussionmentioning

confidence: 99%

Rototaxis: Localization of active motion under rotation

Zheng

Löwen

2020

Phys. Rev. Research

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The ability to navigate in complex, inhomogeneous environments is fundamental to survival at all length scales, giving rise to the rapid development of various subfields in bio-locomotion such as the well established concept of chemotaxis. In this work, we extend this existing notion of taxis to rotating environments and introduce the idea of "roto-taxis" to bio-locomotion. In particular, we explore both overdamped and inertial dynamics of a model synthetic self-propelled particle in the presence of constant global rotation, focusing on the particle's ability to localize near a rotation center as a survival strategy. We find that in the overdamped regime, the swimmer is in general able to generate a self restoring active torque that enables it to remain on stable epicyclical-like trajectories. On the other hand, for underdamped motion with inertial effects, the intricate competition between self-propulsion and inertial forces, in conjunction with the rototactic torque leads to complex dynamical behavior with nontrivial phase space of initial conditions which we reveal by numerical simulations. Our results are relevant for a wide range of setups, from vibrated granular matter on turntables to microorganisms or animals swimming near swirls or vortices.biological movement | chemotaxis| microswimmers | active matter

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“…Importantly, if wider sperm heads experience more drag and reduced speeds [16], there may be an evolutionary trade-off between elongated shapes optimized for motility and relatively wider shapes that promote sperm-sperm interactions. Such evolutionary trade-offs between multiple tasks that influence fitness have been observed to drive morphological diversity in bacteria [77] and could potentially explain the benefit of forming groups when cell shape is not optimized for speed.…”

Section: Discussionmentioning

confidence: 99%

The social shape of sperm: Using an integrative machine-learning approach to examine sperm ultrastructure and collective motility

Hook

Yang

Campanello

et al. 2020

Preprint

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Sperm are one of the most morphologically diverse cell types in nature, yet they also exhibit remarkable behavioral variation, including the formation of collective groups of cells that swim together for motility or transport through the female reproductive tract. Here we take advantage of the natural variation in sperm traits observed across Peromyscus mice to test the hypothesis that the morphology of the rodent sperm head influences their sperm aggregation behavior. Using machine learning and traditional morphometric approaches to quantify and analyze their complex shapes, we show that the elongation of the sperm head is the most distinguishing morphological trait in these rodents and, as predicted, significantly associates with collective sperm movements obtained from in vitro observations. We then successfully use neural network analysis to predict the size and proportion of sperm aggregates from sperm head morphology and show that species whose sperm feature relatively wider heads aggregate more often and form larger groups, providing support for the theoretical prediction that an adhesive region around the equatorial region of the sperm head mediates these unique gametic interactions. Together these findings advance our understanding of how even subtle variation in sperm design can drive differences in sperm function and performance.Subject AreasEvolution, Cellular Biology, Behavior

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Motile curved bacteria are Pareto-optimal

Cited by 59 publications

References 53 publications

Sheathless Shape-Based Separation of Candida Albicans Using a Viscoelastic Non-Newtonian Fluid

Sheathless Shape-Based Separation of Candida Albicans Using a Viscoelastic Non-Newtonian Fluid

Rototaxis: Localization of active motion under rotation

The social shape of sperm: Using an integrative machine-learning approach to examine sperm ultrastructure and collective motility

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