Motilin and human colonic activity

Rennie, J. B.; Christofides, Nicos; Mitchenere, P.; Ag, Johnson; Bloom, S.R.

doi:10.1016/0167-0115(80)90203-7

Cited by 8 publications

(11 citation statements)

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“…In our study, however, plasma motilin concentration elevated significantly by the psychological stress in the IBS patients. Because motilin is the only substance known to be active on the gastrointestinal motility during the interdigestive state (Itoh et al 1976) and because it was shown that an infusion of motilin provoked a significant increase in colonic myoelectric and pressure changes (Rennie et al 1980), our results suggest that the interdigestive colonic motor activity under the stress may be at least in part influenced by plasma motilin concentration in the IBS patients. Correlation between motilin and colonic motility in the IBS patients was excessively of interest.…”

Section: Discussionmentioning

confidence: 70%

Colonic motility, autonomic function, and gastrointestinal hormones under psychological stress on irritable bowel syndrome.

Fukudo

Suzuki

1987

Tohoku J. Exp. Med.

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Section: Discussionmentioning

confidence: 70%

Colonic motility, autonomic function, and gastrointestinal hormones under psychological stress on irritable bowel syndrome.

Fukudo

Suzuki

1987

Tohoku J. Exp. Med.

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“…Motilin, known to act primarily in the upper gut43 but also proposed to stimulate colonic motor activity,44 and CRF were the only peptides that differed between groups. Higher motilin levels were observed in patients, but more interesting were levels of motilin in the IBS subgroups.…”

Section: Discussionmentioning

confidence: 98%

An exaggerated sensory component of the gastrocolonic response in patients with irritable bowel syndrome

Simrén

2001

Gut

182

135

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Background/aims-Visceral hypersensitivity is a feature of the irritable bowel syndrome (IBS). Postprandial symptoms are common in these patients. The eVects of nutrients on colonic perception in IBS are incompletely understood. Subjects-We studied 13 healthy subjects and 16 patients with IBS-eight had diarrhoea predominant (IBS-D) and eight constipation predominant (IBS-C) IBS. Methods-Colonic perception thresholds to balloon distension and viscerosomatic referral pattern were assessed before and after duodenal infusion of lipid or saline, respectively. At the end of the infusions, plasma levels of gastrointestinal peptides were determined. Results-Lipids lowered the thresholds for first sensation, gas, discomfort, and pain in the IBS group but only for gas in the control group. The percent reduction in thresholds for gas and pain after lipids was greater in the IBS and IBS-D groups but not in the IBS-C group compared with controls. IBS patients had an increased area of referred discomfort and pain after lipids compared with before infusion whereas the referral area remained unchanged in controls. No group diVerences in colonic tone or compliance were observed. In both groups higher levels of cholecystokinin, pancreatic polypeptide, peptide YY, vasoactive intestinal polypeptide, and neuropeptide Y were seen after lipids. Motilin levels were higher in patients and diVerences in the subgroups were observed. Levels of corticotrophin releasing factor were lower in the constipated group than in the diarrhoea group. Conclusions-Postprandial symptoms in IBS patients may be explained in part by a nutrient dependent exaggerated sensory component of the gastrocolonic response.

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“…Another effect of motilin in the upper GI tract is to stimulate gallbladder emptying 28 . The role of motilin on colonic motility is less well studied, but there are indications that it has a stimulatory effect on colonic motor activity as well 14,15 …”

Section: Discussionmentioning

confidence: 99%

“…A stimulatory effect of motilin and erythromycin, a motilin agonist, on colonic motility is supported by some studies, 14,15 whereas other fail to support this assumption 31 . The effects of high motilin levels in IBS patients on the colonic motor pattern are therefore unclear.…”

Section: Discussionmentioning

confidence: 99%

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High interdigestive and postprandial motilin levels in patients with the irritable bowel syndrome

Simrén

Bjõrnsson

Abrahamsson

2004

Neurogastroenterology Motil

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Motilin shows cyclic variation with the different phases of the migrating motor complex (MMC). Altered motilin levels have been found in irritable bowel syndrome (IBS) patients, but in these studies motilin levels were analysed without the knowledge of the phases of MMC. We included 13 healthy controls (HC) and 24 patients with IBS [12 diarrhoea-predominant (IBS-D) and 12 constipation-predominant (IBS-C)]. We performed interdigestive and postprandial antroduodenojejunal manometry and blood samples for analysis of motilin were drawn. Group differences in plasma levels of motilin were analysed during mid-phase II, just before the start of phase III (pre-III), during phase I, immediately before the meal and 30 and 60 min after the 500 kcal mixed meal. Higher motilin levels were observed in IBS vs HC in both the interdigestive and postprandial periods (P < 0.05). No significant differences between IBS-C and IBS-D were observed. The cyclic variation of motilin during MMC and the meal response was similar in IBS and controls. IBS patients, irrespective of the predominant bowel habit, demonstrate higher motilin levels than HCs in all phases of the MMC and also after a meal. These findings may bear some pathophysiological importance in IBS and relate to the gastrointestinal dysmotility often seen in these patients.

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Motilin and human colonic activity

Cited by 8 publications

References 0 publications

Colonic motility, autonomic function, and gastrointestinal hormones under psychological stress on irritable bowel syndrome.

Colonic motility, autonomic function, and gastrointestinal hormones under psychological stress on irritable bowel syndrome.

An exaggerated sensory component of the gastrocolonic response in patients with irritable bowel syndrome

High interdigestive and postprandial motilin levels in patients with the irritable bowel syndrome

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