Motilin-induced gastric contractions signal hunger in man

Abstract

Motilin-induced gastric phase III is a hunger signal from GIT in man.

Intragastric infusion of denatonium benzoate attenuates interdigestive gastric motility and hunger scores in healthy female volunteers

“…In keeping with a role for gastric 274 phase III in determining interdigestive hunger, this switch was accompanied by a decrease in 275 hunger scores (20). Similar to our findings in the lingual system, the response to DB was sex-276 dependent, being more pronounced in women than in men.…”

“…One 305 factor contributing to this difference in hunger changes could be the lower occurrence of 306 gastric phase III contractions in male participants during the present study. Previous studies 307 did not report a difference in association of phase III contractions and hunger ratings between 308 men and women (20), but this aspect needs to be studied in more detail and in larger numbers 309 in future research. 310 Our study showed that only motilin plasma levels were decreased after administration of DB.…”

“…Endogenous motilin 52 plasma levels, but not ghrelin, fluctuate in synchrony with antral contractility of the MMC, to 53 reach a peak just before the occurrence of a gastric phase III (16,17,19). We recently showed 54 that motilin-induced gastric phase III contractions of the MMC signal hunger in healthy 55 volunteers and that motilin plasma levels were closely associated with interdigestive hunger 56 ratings (20,21). In 1916, Carlson (22) reported an inhibitory effect of intragastrically 57 administered bitter compounds on both fasting gastric contractility and hunger sensations, 58 but the underlying mechanism was not elucidated.…”

Redefining the functional roles of the gastrointestinal migrating motor complex and motilin in small bacterial overgrowth and hunger signaling

“…In patients with unexplained loss of appetite, gastric phase III occurrence is suppressed, and this is associated with lower hunger ratings. It is unclear whether this is also associated with altered motilin release (50). This recent concept of changed antroduodenal motility and motilin plasma levels in patients with anorexia (nervosa) deserves further attention.…”

“…Moreover, although administration of either motilin or ghrelin was able to induce premature gastric phase III contractions, only motilin-induced phase III contractions were associated with increased hunger ratings. Administration of the motilin receptor agonist erythromycin was also able to induce both gastric phase III contractions and hunger peaks, but induction of random gastric contractions through administration of the cholinesterase inhibitor neostigmine did not alter hunger ratings (50). These findings correspond with the studies of Cannon and Carlson and identify motilin as the missing link between the gastric motility in the periphery and the sensation of hunger generated by the central Duodenum B1 B2 B3 B4 B5 B6 B7 B8 B9 B10 I I I e s a h P I I e s a h P I e s a nervous system, since only motilin-induced gastric contractions are able to inflict hunger increases.…”