Motilin kinetics and effects on proximal stomach in patients with functional dyspepsia (FD) and healthy volunteers

Abstract

S inhibitory effect were not significantly different between hetEMs and homEMs, although there was a trend towards an increased AUC and acid-inhibitory effect in hetEMs. Therefore we compared the acid-inhibitory effect of LPZ and OPZ to baseline.Compared with baseline median 24 h pH and % of time pH > 4 at day 1 were significantly increased in hetEMs, but not in homEMs for both LPZ and OPZ. At day 6 the differences in acid-inhibitory effect between hetEMs and homEMs were not significant.At day 1 of administration acid inhibitory effect of LPZ 15 mg and OPZ 10 mg is affected by CYP2C19 polymorphism. Compared with baseline, there was at day 1 a significant acid-inhibitory effect in hetEMs, but not in homEMs.